David Sjostrom, Ph.D., deputy chief physicist, Herlev Hospital, Department of Oncology, Division of Radiotherapy, Herlev, Denmark, shares the first clinical experience treating cancer patients with the Varian Ethos radiation therapy system. He spoke to ITN at ASTRO 2019, where he presented information on the first 5 patients in the world being treated with this new technology. It uses artificial intelligence to take the onboard cone beam CT scans to automatically create an adaptive plan for any changes in patient weight loss, bladder volume, or change in tumor size. The plan can be available in minutes while the patient is on the table. It enables sparing of more healthy tissue and makes adaptive therapy much easier to use.