News | Breast Imaging | October 19, 2022

The trial is designed to determine whether contrast-enhanced mammography improves breast cancer detection for women with dense breasts 

Left: Recombined image of the CEM exam showing iodine uptake. Right: Standard digital mammogram.

Left: Recombined image of the CEM exam showing iodine uptake.
Right: Standard digital mammogram. 


October 19, 2022 — The American College of Radiology (ACR) is set to launch the Contrast-Enhanced Mammography Imaging Screening Trial (CMIST) in collaboration with the Breast Cancer Research Foundation(BCRF) and GE Healthcare.  The trial will determine whether contrast-enhanced mammography improves breast cancer detection and reduce false-positive exams in women with dense breasts. 

About 43 percent of women aged 40 to 72 have dense breasts, which can make detection of breast cancer more challenging when using mammography alone.[1] The CMIST study seeks to determine if contrast-enhanced mammography (CEM) provides more accurate cancer detection compared to digital breast tomosynthesis (DBT) in women with dense breasts. 

CEM combines mammography and vascular-based screening methods in a simple and quick procedure to highlight areas of unusual blood flow patterns that may indicate malignancy. Early studies of CEM in screening women with dense breasts have shown the potential benefit of CEM in the detection of breast cancer. 

“In the fight against breast cancer, unfortunately it is all too common for women with dense breasts to face an agonizing wait for answers," says Catherine Lezy, General Manager for Mammography at GE Healthcare. “We know that CEM technology can be a game-changer in helping improve breast cancer outcomes. I’m excited that both GE Healthcare’s Senographe Pristina mammography system and SenoBright HD CEM technology, together with GE Healthcare Pharmaceutical Diagnostics contrast media will be used to further evaluate the clinical benefits of CEM. We hope that this will help clinicians feel more confident in their diagnosis and help patients get the answers they deserve." 

The planned study will be managed by the American College of Radiology Center for Research and Innovation, with support from the Breast Cancer Research Foundation and GE Healthcare, under the supervision of Principal Investigator Christopher Comstock, MD, FACR, FSBI, Director of Breast Imaging Clinical Trials, Memorial Sloan Kettering Cancer Center, who said: “The CMIST Trial can help determine if contrast-enhanced mammography can provide a more sensitive and specific method for breast cancer screening in women with dense breasts, finding many cancers missed with our current methods.” 

"Through CMIST, we hope to gain increased understanding of the potential role of contrast mammography for women with dense breasts with the goal of developing more individualized breast imaging strategies.” said Etta Pisano, MD, FACR, American College of Radiology Chief Research Officer. 

“Given recent trends in the rising incidence of breast cancer, it is a key imperative to improve current diagnostic tools,” said Dorraya El-Ashry, PhD, Chief Scientific Officer of the Breast Cancer Research Foundation. “We know that early detection is a key determinant of survival and improving diagnostic technology for women with dense breasts will undoubtedly save lives.” 

As the world observes Breast Cancer Awareness month throughout October, women are encouraged to ‘Don’t Skip’ their annual mammogram - where they can learn more about their own risk factors, including breast density, and consider the best care options with the help of their physician. Click here to learn more. 


Related Content

News | Mammography

November 29, 2022 — One in five women is likely to forgo additional testing after an abnormal finding on a screening ...

Time November 29, 2022
arrow
News | Mammography

November 28, 2022 — The Radiological Society of North America (RSNA) has announced the launch of the RSNA Screening ...

Time November 28, 2022
arrow
News | Artificial Intelligence

November 28, 2022 — Flywheel, a leading data management platform for biomedical research and collaboration, is creating ...

Time November 28, 2022
arrow
News | Breast Imaging

November 25, 2022 — Hologic, Inc. will exhibit its extensive portfolio of breast and skeletal health products at the ...

Time November 25, 2022
arrow
News | Artificial Intelligence

November 25, 2022 — Delphinus Medical Technologies has announced the installation of its SoftVue 3D Whole Breast ...

Time November 25, 2022
arrow
News | Ultrasound Women's Health

November 22, 2022 — Sirona Medical, the leader in cloud-native radiology workflow software, today announced a ...

Time November 22, 2022
arrow
News | Ultrasound Women's Health

November 22, 2022 — Delphinus Medical Technologies today announced that it will host demonstrations of the commercially ...

Time November 22, 2022
arrow
Videos | ASTRO

Dr. Frank A. Vicini, MD, FACR, FASTRO, FABS, who is a radiation oncologist with GenesisCare, discussed his findings from ...

Time November 09, 2022
arrow
News | ACR

November 8, 2022 — The American College of Radiology (ACR) is urging screening centers across the country to “open doors ...

Time November 08, 2022
arrow
Feature | Breast Imaging | By Andrew Smith and Paola Wisner

Patients are the motivational driver for innovation in breast imaging companies. Their needs and experiences help ...

Time November 04, 2022
arrow
Subscribe Now