Breast Density

The Imagio Breast Imaging System combines laser light and sound with conventional ultrasound technology to provide fused functional and anatomic images (referred to as optoacoustic/ultrasound or OA/US) in real time, increasing confidence in diagnostic accuracy.

Left to right: Subtraction right mediolateral oblique (MLO) CEM was non-diagnostic because of artifact, potentially due to motion misregistration from extended exposure time; subtraction right MLO implant displaced CEM image shows 5.8 cm enhancing mass (arrow); contrast-enhanced MRI sagittal subtraction image shows concordant mass (arrow).

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Comparison of breast cancer mortality rates (red squares) and distant-stage breast cancer incidence rates from SEER9 (blue dots) and SEER18 (green dots) per 100,000 for white women aged, A, 20–39, B, 40–69, and, C, 70–79 years (3,7,8). Image courtesy of Radiology 

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The four standard views of an individual mammogram were fed into Mirai. The image encoder mapped each view to a vector, and the image aggregator combined the four view vectors into a single vector for the mammogram. In this work, we used a single shared ResNet-18 as an image encoder, and a transformer as our image aggregator. The risk factor predictor module predicted all the risk factors used in the Tyrer-Cuzick model, including age, detailed family history, and hormonal factors, from the mammogram vector. The additive hazard layer combined information from both the image aggregator and risk factors (predicted or given) to predict coherent risk assessments across 5 years (Yr).