News | Magnetic Resonance Imaging (MRI) | January 09, 2018

State-of-the-Art MRI Technology Bypasses Need for Biopsy

New MRI technology out of UT Southwestern Harold C. Simmons Comprehensive Cancer Center eliminates the need for painful biopsy in cancer patients. 

State-of-the-Art MRI Technology Bypasses Need for Biopsy

January 9, 2018 – The most common type of tumor found in the kidney is generally quite small (less than 1.5 in). These tumors are usually found by accident when computerized axial tomography (CAT) scans are performed for other reasons, and the serendipitous finding poses a problem for doctors. Are these tumors malignant and need to be surgically removed because they may threaten the patient’s life? Or are they benign and can be left alone?

The decision is often made with a biopsy. By sampling the tumor, doctors are able to determine whether the cancer is benign or malignant. However, biopsies are invasive procedures and not without risks.

Investigators with the Kidney Cancer Program at UT Southwestern Harold C. Simmons Comprehensive Cancer Center have developed a magnetic resonance imaging (MRI) technology that can provide information about the nature and aggressiveness of the cancer without having to perform a biopsy.

The team, led by Ivan Pedrosa, M.D., and Jeffrey Cadeddu, M.D., co-authors of the study highlighted on the cover of The Journal of Urology, have developed multiparametric magnetic resonance imaging (mpMRI) protocols that tell physicians with high confidence whether the tumor is aggressive or not. These protocols allow investigators to evaluate the chemical composition of the tumor without a biopsy. This composition allows doctors to infer what type of cancer it is.

“Using mpMRI, multiple types of images can be obtained from the renal mass and each one tells us something about the tissue,” said Pedrosa, professor of radiology and chief of magnetic resonance imaging.

The standardized diagnostic algorithm is largely based on the appearance of the renal mass on specific MRI images, namely T2-weighted images and those immediately after intravenous (IV) dye reaches the kidney. Other images are also used that indicate whether fat is present in the tumor. Based on the algorithm, physicians can recognize clear cell carcinoma (ccRCC), the most common and aggressive form of kidney cancer, with 80 pecent confidence.

“Using mpMRI, doctors at UT Southwestern have a four-in-five chance of identifying clear cell cancer” said Pedrosa.

The data collected from this study support the use of mpMRI to reduce the number of biopsies.

“Biopsies are not entirely free of pain and discomfort,” said Cadeddu, professor of urology and radiology at UT Southwestern. “Some patients, in fact, choose to observe the cancer simply to avoid the pain of the biopsy,” he said.

Both Pedrosa and Cadeddu are supported by a Specialized Program of Research Excellence (SPORE) award from the National Cancer Institute.

For more information: www.jurology.com

 

Related Content

Report Finds Identifying Patients for Lung Cancer Screening Not So Simple
News | Lung Cancer | June 18, 2018
New findings in the current issue of The American Journal of Managed Care suggest that getting the right patients to...
Elekta Unity High-Field MR-Linac Receives CE Mark
News | Image Guided Radiation Therapy (IGRT) | June 18, 2018
Elekta announced that its Elekta Unity magnetic resonance radiation therapy (MR/RT) system has received CE mark,...
Hitachi Medical Systems Europe Named Imaging Supplier for London Prostate Cancer Program
News | Prostate Cancer | June 14, 2018
Hitachi Medical Systems Europe has been awarded the contract to supply six ultrasound systems as part of the RAPID...
Washington University in St. Louis Begins Clinical Treatments With ViewRay MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | June 14, 2018
June 14, 2018 — The Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in S
Reduced hippocampal volume on MRI

This figure shows reduced hippocampal volume over the course of 6 years as seen on progressive volumetric analysis and also coronal MRI evaluations (arrows).Progressive volume loss in the mesial temporal lobe on MRI is a characteristic imaging feature of AD. This patient was a case of Alzheimer’s Dementia.

 

News | Neuro Imaging | June 12, 2018
According to a UCLA Medical Center study, a new technology shows the potential to help doctors better determine when...
How AI and Deep Learning Will Enable Cancer Diagnosis Via Ultrasound

The red outline shows the manually segmented boundary of a carcinoma, while the deep learning-predicted boundaries are shown in blue, green and cyan. Copyright 2018 Kumar et al. under Creative Commons Attribution License.

News | Ultrasound Imaging | June 12, 2018 | Tony Kontzer
June 12, 2018 — Viksit Kumar didn’t know his mother had...
High Prevalence of Atherosclerosis Found in Lower Risk Patients
News | Magnetic Resonance Imaging (MRI) | June 08, 2018
Whole-body magnetic resonance angiography (MRA) found a surprisingly high prevalence of atherosclerosis in people...
Philips Receives FDA 510(k) for Ingenia Elition MR System
Technology | Magnetic Resonance Imaging (MRI) | June 07, 2018
Philips announced that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its...
American Cancer Society Updates Colorectal Cancer Screening Guideline
News | Colonoscopy Systems | May 30, 2018
An updated American Cancer Society guideline says colorectal cancer screening should begin at age 45 for people at...
Researchers Use Radiomics to Overcome False Positives in Lung Cancer CT Screening
News | Advanced Visualization | May 29, 2018
A team of researchers including investigators from Mayo Clinic has identified a technology to address the problem of...
Overlay Init