Clinical Trials

Clinical trials and studies about imaging technology can be found on this channel.

Findings indicate that PPC and GG are highly predictive of overall upstaging by PSMA PET/CT for patients with high-risk prostate cancer

Image courtesy of UCLA Health

News | PET-CT | February 23, 2021
February 23, 2021 — A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center helps identify which...
Axial FLAIR MR image shows T2 prolongation in bilateral middle cerebellar peduncles (arrows). Findings were associated with restricted diffusion and areas of T1 hypointense signal without enhancement or abnormal susceptibility. Image courtesy of American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

Axial FLAIR MR image shows T2 prolongation in bilateral middle cerebellar peduncles (arrows). Findings were associated with restricted diffusion and areas of T1 hypointense signal without enhancement or abnormal susceptibility. Image courtesy of American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

News | Coronavirus (COVID-19) | February 22, 2021
February 22, 2021 — According to an open-access article in ARRS' American Journal of Roentgenology (AJR), COVID-19-...
F-18 FES PET images of patients with ER+/PR+/HER2- invasive ductal carcinoma. Left panel: Progressive disease seen at the 8-week time-point in a patient on sequential therapy. Right panel: Stable disease through all 3 time-points, remaining on study therapy for 6.7 months until disease progression on combined vorinostat aromatase inhibitor therapy. Image created by Lanell M Peterson, Research Scientist, University of Washington Medical Oncology, Seattle WA.

F-18 FES PET images of patients with ER+/PR+/HER2- invasive ductal carcinoma. Left panel: Progressive disease seen at the 8-week time-point in a patient on sequential therapy. Right panel: Stable disease through all 3 time-points, remaining on study therapy for 6.7 months until disease progression on combined vorinostat aromatase inhibitor therapy. Image created by Lanell M Peterson, Research Scientist, University of Washington Medical Oncology, Seattle WA.

News | Molecular Imaging | February 22, 2021
February 22, 2021 — Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-...
Example MR images from paediatric brain tumour patients. This first column shows T1-weighted images following the injection of gadolinium contrast agent. The second column shows T2-weighted images and the final column shows apparent diffusion coefficient maps calculated from diffusion-weighted images. (a–c) are taken from a patient with a Pilocytic Astrocytoma, (d–f) are from a patient with an Ependymoma and (g–i) were acquired from a patient with a Medulloblastoma.

Example MR images from paediatric brain tumour patients. This first column shows T1-weighted images following the injection of gadolinium contrast agent. The second column shows T2-weighted images and the final column shows apparent diffusion coefficient maps calculated from diffusion-weighted images. (ac) are taken from a patient with a Pilocytic Astrocytoma, (df) are from a patient with an Ependymoma and (gi) were acquired from a patient with a Medulloblastoma. Image courtesy of Nature Research Journal

News | Pediatric Imaging | February 17, 2021
February 17, 2021 — Diffusion weighted imaging and machine learning can successfully classify the diagnosis and...
T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.

T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.

News | Magnetic Resonance Imaging (MRI) | February 17, 2021
February 17, 2021 — A new paper, "Is it time to switch your T1W sequence? Assessing the impact of prospective motion...
Immunotherapy-based precision medicine clinical trials being developed

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News | Prostate Cancer | February 16, 2021
February 16, 2021 — Black men die more often of prostate cancer yet, paradoxically, have greater survival benefits from...
The research collaboration agreement covers a joint clinical retrospective study on liver fibrosis severity in Non-Alcoholic Steato-Hepatitis (NASH) patients
News | Artificial Intelligence | February 10, 2021
February 10, 2021 — Median Technologies announced the company has signed a research collaboration agreement with the...
Unhealthy lifestyles, various diseases, stress, and aging can all contribute to an imbalance between the production of ROS and the body's ability to reduce and eliminate them. The resulting excessive levels of ROS cause "oxidative stress".

Unhealthy lifestyles, various diseases, stress, and aging can all contribute to an imbalance between the production of ROS and the body's ability to reduce and eliminate them. The resulting excessive levels of ROS cause "oxidative stress". Graphic courtesy of National Institutes for Quantum and Radiological Science and Technology

News | Magnetic Resonance Imaging (MRI) | February 10, 2021
February 10, 2021 — Oxygen is essential for human life, but within the body, certain biological environmental...
Phase III clinical trial of men with a clinical suspicion of prostate cancer finds MRI with targeted biopsies to be more accurate at diagnosis and less intrusive than current standard
News | Magnetic Resonance Imaging (MRI) | February 08, 2021
February 8, 2021 — The results of a Phase III randomized clinical trial have shown that when it comes to detecting...
A study led by UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine shows that Black children are 18% less likely to get imaging tests as part of their emergency department visit compared to White children. Hispanic children are 13% less likely to have imaging done than Whites.

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News | Pediatric Imaging | February 03, 2021
February 3, 2021 — A study led by UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of...
Bright spots indicate that cancer cells have responded to a one-day challenge with estrogen in this positron emission tomography (PET) scan of a woman with breast cancer. In a small study, researchers at Washington University School of Medicine in St. Louis found that only women whose tumors responded to estrogen challenge benefited from hormone therapy. The findings could help doctors choose the treatments most likely to help their patients. Image courtesy of Farrokh Dehdashti

Bright spots indicate that cancer cells have responded to a one-day challenge with estrogen in this positron emission tomography (PET) scan of a woman with breast cancer. In a small study, researchers at Washington University School of Medicine in St. Louis found that only women whose tumors responded to estrogen challenge benefited from hormone therapy. The findings could help doctors choose the treatments most likely to help their patients. Image courtesy of Farrokh Dehdashti

News | PET Imaging | February 03, 2021
February 3, 2021 — Hormone therapy commonly is given as a targeted treatment for women whose cancer cells carry...
Kaplan–Meier curves for the high-risk individuals and the ones with low or medium risk according to AI-severity. The threshold to assign individuals into a high-risk group was the 2/3 quantile of the AI-severity score computed for patients of the KB development cohort. a Kaplan–Meier curves were obtained for the 150 leftover KB patients from the development cohort. b Kaplan–Meier curves were obtained for the 135 patients of the IGR validation cohort. p-values for the log-rank test were equal to 4.77e–07 (KB

Kaplan–Meier curves for the high-risk individuals and the ones with low or medium risk according to AI-severity. The threshold to assign individuals into a high-risk group was the 2/3 quantile of the AI-severity score computed for patients of the KB development cohort. a Kaplan–Meier curves were obtained for the 150 leftover KB patients from the development cohort. b Kaplan–Meier curves were obtained for the 135 patients of the IGR validation cohort. p-values for the log-rank test were equal to 4.77e–07 (KB) and 4.00e–12 (IGR). The two terciles used to determine threshold values for low-, medium-, and high-risk groups were equal to 0.187 and 0.375. Diamonds correspond to censoring of patients who were still hospitalized at the time when data ceased to be updated. The bands correspond to the sequence of the 95% confidence intervals of the survival probabilities for each day. KB Kremlin-Bicêtre hospital, IGR Institut Gustave Roussy hospital. Courtesy of Nature Communications.

News | Coronavirus (COVID-19) | February 01, 2021
February 1, 2021 — COVID-19 vaccine distribution has begun across the globe, while many countries are still struggling...

Beckman researcher, Brad Sutton (Photo courtesy the Beckman Institute)

News | Magnetic Resonance Imaging (MRI) | February 01, 2021
February 1, 2021 — Researchers at the Beckman Institute for Advanced Science and Technology were part of a...
Ludwig Chicago Co-director Ralph Weichselbaum and Kaiting Yang, a postdoctoral researcher in Weichselbaum's lab.

Ludwig Chicago Co-director Ralph Weichselbaum and Kaiting Yang, a postdoctoral researcher in Weichselbaum's lab. Image courtesy of Ludwig Cancer Research

News | Radiation Therapy | January 28, 2021
January 28, 2021 — A study led by Ludwig Chicago Co-director Ralph Weichselbaum, M.D., and Yang-Xin Fu, M.D., Ph.D., of...
The four standard views of an individual mammogram were fed into Mirai. The image encoder mapped each view to a vector, and the image aggregator combined the four view vectors into a single vector for the mammogram. In this work, we used a single shared ResNet-18 as an image encoder, and a transformer as our image aggregator. The risk factor predictor module predicted all the risk factors used in the Tyrer-Cuzick model, including age, detailed family history, and hormonal factors, from the mammogram vector.

The four standard views of an individual mammogram were fed into Mirai. The image encoder mapped each view to a vector, and the image aggregator combined the four view vectors into a single vector for the mammogram. In this work, we used a single shared ResNet-18 as an image encoder, and a transformer as our image aggregator. The risk factor predictor module predicted all the risk factors used in the Tyrer-Cuzick model, including age, detailed family history, and hormonal factors, from the mammogram vector. The additive hazard layer combined information from both the image aggregator and risk factors (predicted or given) to predict coherent risk assessments across 5 years (Yr).

News | Breast Imaging | January 28, 2021
January 28, 2021 — A new machine learning algorithm based on mammograms can estimate the risk of breast cancer in women...
Most research on sleep is conducted using electroencephalography (EEG), a method that entails measuring brain activity through electrodes placed along a patient's scalp. However, Anjali Tarun, a doctoral assistant at EPFL's Medical Image Processing Laboratory within the School of Engineering, decided to investigate brain activity during sleep using magnetic resonance imaging, or MRI.

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News | Magnetic Resonance Imaging (MRI) | January 26, 2021
January 26, 2021 — Our state of consciousness changes significantly during stages of deep sleep, just as it does in a...
An additional external-beam radiation dose delivered directly to the tumor can benefit the prospects of men with non-metastatic prostate cancer, without causing additional side effects. The risk of relapse within five years for these men is smaller than for men who did not receive this boost, as shown by a large-scale study initiated by UMC Utrecht in collaboration with the Netherlands Cancer Institute, UZ Leuven and Radboudumc.
News | Prostate Cancer | January 25, 2021
January 25, 2021 — An additional external-beam radiation dose delivered directly to the tumor can benefit the prospects...
News | Ultrasound Imaging | January 20, 2021
January 20, 2021 — Exact Therapeutics, a clinical stage precision medicine company, announced a collaboration with GE...
Clinical utility of Axumin (fluciclovine F 18) being investigated in expanded areas of cancer imaging

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News | PET Imaging | January 18, 2021
January 18, 2021 — Blue Earth Diagnostics, a Bracco company and recognized leader in the development and...
Myocarditis among recovering COVID-19 athletes less common than previously reported

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News | Cardiac Imaging | January 11, 2021
January 11, 2021 — In a letter published in the December issue of the American Heart Association's medical journal ...