Clinical Trials

Clinical trials and studies about imaging technology can be found on this channel.

The study investigates targeted drug delivery by focused ultrasound for pancreatic cancer

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News | Focused Ultrasound Therapy | July 01, 2021
July 1, 2021 — The University of Oxford announced commencement of enrollment for the Phase I PanDox study of...
In the STOIC study, readers classified CT exams as COVID positive, COVID negative or normal. The readers had access to the CT scans using a 3D image visualization web application, allowing scrolling through the entire lung volume in the coronal, sagittal or axial transverse plane. The CT scan shown here has been classified as COVID positive due to the presence of bilateral ground glass opacities and absence of features such as mucoid impaction, bronchiolar nodules, segmental, lobar consolidation. RSNA Image

In the STOIC study, readers classified CT exams as COVID positive, COVID negative or normal. The readers had access to the CT scans using a 3-D image visualization web application, allowing scrolling through the entire lung volume in the coronal, sagittal or axial transverse plane. The CT scan shown here has been classified as COVID positive due to the presence of bilateral ground glass opacities and absence of features such as mucoid impaction, bronchiolar nodules, segmental or lobar consolidation. Image courtesy of RSNA

Feature | Coronavirus (COVID-19) | July 01, 2021 | By Dave Fornell, Editor
In a new study published in Radiology of more than 10,000 patients, researchers found that chest computed tomography (...
According to a new study, by the Harvey L. Neiman Health Policy Institute and the American College of Radiology’s National Mammography Database Committee, the most influential radiologist characteristics impacting mammography interpretive performance were geography, breast sub-specialization, performance of diagnostic mammography, and performance of diagnostic ultrasound.

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News | Breast Imaging | June 23, 2021
June 23, 2021 — According to a new study by the Harvey L. Neiman Health Policy Institute and the American College of...
A phase III clinical trial has validated the effectiveness of the prostate-specific membrane antigen (PSMA)-targeted radiotracer 18F-DCFPyL in detecting and localizing recurrent prostate cancer.

Figure 1. Case example: A 54-year-old man with a history of RP+LND and a subsequent PSA of 1.25 ng/mL had no evidence of disease by baseline imaging. Piflufolastat F 18 (18F-DCFPyL)- PET/CT accurately detected biochemically recurrent prostate cancer with the PSMA PET/CT scan identifying positive left (left panel) and right peri-rectal lymph nodes (right panel).

News | Prostate Cancer | June 21, 2021
June 21, 2021 — A phase III clinical trial has validated the effectiveness of the prostate-specific membrane antigen (...
The prevalence of genetic mutations associated with breast cancer in Black and white women is the same, according to a new JAMA Oncology study of nearly 30,000 patients led by researchers in the Basser Center for BRCA at the Abramson Cancer Center.

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News | Women's Health | June 15, 2021
June 15, 2021 — The prevalence of genetic mutations associated with breast cancer in Black and white women is the same...
The new X-ray scanner can provide detailed information about the internal makeup of rocks, which could be useful for archaeologists studying fossils or miners making decisions about which ore to use in their extraction facilities. Image courtesy of Joel Greenberg, Duke University

The new X-ray scanner can provide detailed information about the internal makeup of rocks, which could be useful for archaeologists studying fossils or miners making decisions about which ore to use in their extraction facilities. Image courtesy of Joel Greenberg, Duke University

News | X-Ray | June 10, 2021
June 10, 2021 — Engineers at Duke University have demonstrated a prototype X-ray scanning machine that reveals not just...
The U.S. Food and Drug Administration (#FDA) approved #Aduhelm (#aducanumab) for the treatment of #Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was approved using the accelerated approval pathway, which can be used for a drug for a serious or life-threatening illness that provides a meaningful therapeutic advantage over existing treatments.

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News | PET Imaging | June 07, 2021
June 7, 2021 — The U.S. Food and Drug Administration (FDA) approved Aduhelm (aducanumab) for the treatment of Alzheimer...
Feature | Coronavirus (COVID-19) | May 26, 2021 | By Dave Fornell, Editor
May 26, 2021 — There are increasing reports of persistent symptoms after a patient recovers from COVID-19, now called...
The experimental drug avasopasem manganese protects healthy tissue while enhancing radiation's capacity to kill cancerous tumor cells by converting superoxide to hydrogen peroxide. Image courtesy of Michael Story, Ph.D.

The experimental drug avasopasem manganese protects healthy tissue while enhancing radiation's capacity to kill cancerous tumor cells by converting superoxide to hydrogen peroxide. Image courtesy of Michael Story, Ph.D.

News | Radiation Therapy | May 21, 2021
May 21, 2021 — An experimental drug that has shown promise in protecting healthy tissue from collateral damage caused...
The drug, known as Avasopasem manganese, is made by Galera Therapeutics. It acts like a natural enzyme called superoxide dismutase and converts superoxide into hydrogen peroxide. Based on its ability to "mop up" damaging superoxide molecules, which are produced by radiation treatment, the drug is currently in clinical trials to test its ability to protect mucosal tissue from the side-effect of radiotherapy.

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News | Radiation Therapy | May 19, 2021
May 19, 2021 — A small drug molecule that appears to protect normal tissue from the damaging effects of radiation, may...
Chest X-ray from patient severely ill from COVID-19, showing (in white patches) infected tissue spread across the lungs. Image courtesy of Nature Publishing or npj Digital Medicine

Chest X-ray from patient severely ill from COVID-19, showing (in white patches) infected tissue spread across the lungs. Image courtesy of Nature Publishing or npj Digital Medicine

News | Coronavirus (COVID-19) | May 14, 2021
May 14, 2021 — Trained to see patterns by analyzing thousands of chest X-rays, a computer program predicted with up to...
Medical researchers at Flinders University have established a new link between high body mass index (BMI) and breast cancer survival rates — with clinical data revealing worse outcomes for early breast cancer (EBC) patients and improved survival rates in advanced breast cancer (ABC).

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News | Women's Health | May 13, 2021
May 13, 2021 — Medical researchers at Flinders University have established a new link between high body mass index (BMI...
After radiosurgery concurrent with nivolumab in 59-year-old patient with melanoma BM (patient 1; Supplemental Tables 3 and 5), F-18 FET PET at follow-up 12 weeks after treatment initiation (bottom row) shows significant decrease of metabolic activity (TBRmean, ?28%) compared with baseline (top row), although MRI changes were consistent with progression according to iRANO criteria. Reduction of metabolic activity was associated with stable clinical course over 10 mo. CE = contrast-enhanced. Image created by

After radiosurgery concurrent with nivolumab in 59-year-old patient with melanoma BM (patient 1; Supplemental Tables 3 and 5), F-18 FET PET at follow-up 12 weeks after treatment initiation (bottom row) shows significant decrease of metabolic activity (TBRmean, ?28%) compared with baseline (top row), although MRI changes were consistent with progression according to iRANO criteria. Reduction of metabolic activity was associated with stable clinical course over 10 mo. CE = contrast-enhanced. Image created by N. Galldiks et al., Research Center Juelich, Juelich, Germany.

News | PET Imaging | May 05, 2021
May 5, 2021 — For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable...
Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with #Down_syndrome (#DS), #researchers from #CaseWesternReserveUniversity, #ClevelandClinic, University Hospitals and other institutions detected subtle differences in the structure and function of the #hippocampus—a region of the #brain tied to memory and learning.

Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus—a region of the brain tied to memory and learning.

News | Magnetic Resonance Imaging (MRI) | April 29, 2021
April 29, 2021 — Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome...
Overview of the scaphoid fracture detection pipeline, which consisted of a segmentation and detection convolutional neural network (CNN). A class activation map is calculated and visualized as a heatmap for fracture localization. Image courtesy of Radiological Society of North America

Overview of the scaphoid fracture detection pipeline, which consisted of a segmentation and detection convolutional neural network (CNN). A class activation map is calculated and visualized as a heatmap for fracture localization. Image courtesy of the Radiological Society of North America

News | Artificial Intelligence | April 28, 2021
April 28, 2021 — An automated system that uses artificial intelligence (AI) is effective at detecting a common type of...
IV contrast-enhanced 2-mSv 4-mm-thick transverse and coronal (b) CT images show inflamed diverticula (arrows), segmental colonic wall thickening, and adjacent pericolic fat stranding. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

IV contrast-enhanced 2-mSv 4-mm-thick transverse and coronal (b) CT images show inflamed diverticula (arrows), segmental colonic wall thickening, and adjacent pericolic fat stranding. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

News | Computed Tomography (CT) | April 09, 2021
April 9, 2021 — According to an open-access article in ARRS' American Journal of Roentgenology (AJR), IV contrast-...
The Moscow Center for Diagnostics and Telemedicine presented clinical research findings during ECR 2021 highlighting that full integration of AI into radiology workflow during the pandemic increased radiologists' productivity
News | Artificial Intelligence | March 22, 2021
March 22, 2021 — Moscow Center for Diagnostics & Telemedicine and RADLogics shared the results of a large-scale...
WVU Rockefeller Neuroscience Institute staff prepare a patient for a first-in-the-world clinical trial to investigate the use of focused ultrasound technology to treat opioid use disorder. (WVU Photo/Brian Persinger)

WVU Rockefeller Neuroscience Institute staff prepare a patient for a first-in-the-world clinical trial to investigate the use of focused ultrasound technology to treat opioid use disorder. (WVU Photo/Brian Persinger)

News | Focused Ultrasound Therapy | March 17, 2021
March 17, 2021 — On the heels of the country’s deadliest year for drug overdoses, the West Virginia University...
Attending the two most recent screening appointments before a breast cancer diagnosis protects against breast cancer death, according to a Queen Mary University of London study of over half a million Swedish women conducted over 24 years

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News | Breast Imaging | March 12, 2021
March 12, 2021 — For women who had participated in both of their previous two screening examinations, the incidence of...
A new study by Rashi Mehta--a researcher with the WVU School of Medicine and Rockefeller Neuroscience Institute--finds that focused ultrasound may induce an immunological healing effect in the brains of Alzheimer's patients.

A new study by Rashi Mehta--a researcher with the WVU School of Medicine and Rockefeller Neuroscience Institute--finds that focused ultrasound may induce an immunological healing effect in the brains of Alzheimer's patients. Image courtesy of Caylie Silveria/West Virginia University

News | Focused Ultrasound Therapy | March 02, 2021
March 2, 2021 — West Virginia University scientists used magnetic resonance imaging (MRI) scans to show what happens...