Clinical Trials

Clinical trials and studies about imaging technology can be found on this channel.

Chest X-ray from patient severely ill from COVID-19, showing (in white patches) infected tissue spread across the lungs. Image courtesy of Nature Publishing or npj Digital Medicine

Chest X-ray from patient severely ill from COVID-19, showing (in white patches) infected tissue spread across the lungs. Image courtesy of Nature Publishing or npj Digital Medicine

News | Coronavirus (COVID-19) | May 14, 2021
May 14, 2021 — Trained to see patterns by analyzing thousands of chest X-rays, a computer program predicted with up to...
Medical researchers at Flinders University have established a new link between high body mass index (BMI) and breast cancer survival rates — with clinical data revealing worse outcomes for early breast cancer (EBC) patients and improved survival rates in advanced breast cancer (ABC).

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News | Women's Health | May 13, 2021
May 13, 2021 — Medical researchers at Flinders University have established a new link between high body mass index (BMI...
After radiosurgery concurrent with nivolumab in 59-year-old patient with melanoma BM (patient 1; Supplemental Tables 3 and 5), F-18 FET PET at follow-up 12 weeks after treatment initiation (bottom row) shows significant decrease of metabolic activity (TBRmean, ?28%) compared with baseline (top row), although MRI changes were consistent with progression according to iRANO criteria. Reduction of metabolic activity was associated with stable clinical course over 10 mo. CE = contrast-enhanced. Image created by

After radiosurgery concurrent with nivolumab in 59-year-old patient with melanoma BM (patient 1; Supplemental Tables 3 and 5), F-18 FET PET at follow-up 12 weeks after treatment initiation (bottom row) shows significant decrease of metabolic activity (TBRmean, ?28%) compared with baseline (top row), although MRI changes were consistent with progression according to iRANO criteria. Reduction of metabolic activity was associated with stable clinical course over 10 mo. CE = contrast-enhanced. Image created by N. Galldiks et al., Research Center Juelich, Juelich, Germany.

News | PET Imaging | May 05, 2021
May 5, 2021 — For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable...
Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with #Down_syndrome (#DS), #researchers from #CaseWesternReserveUniversity, #ClevelandClinic, University Hospitals and other institutions detected subtle differences in the structure and function of the #hippocampus—a region of the #brain tied to memory and learning.

Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus—a region of the brain tied to memory and learning.

News | Magnetic Resonance Imaging (MRI) | April 29, 2021
April 29, 2021 — Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome...
Overview of the scaphoid fracture detection pipeline, which consisted of a segmentation and detection convolutional neural network (CNN). A class activation map is calculated and visualized as a heatmap for fracture localization. Image courtesy of Radiological Society of North America

Overview of the scaphoid fracture detection pipeline, which consisted of a segmentation and detection convolutional neural network (CNN). A class activation map is calculated and visualized as a heatmap for fracture localization. Image courtesy of the Radiological Society of North America

News | Artificial Intelligence | April 28, 2021
April 28, 2021 — An automated system that uses artificial intelligence (AI) is effective at detecting a common type of...
IV contrast-enhanced 2-mSv 4-mm-thick transverse and coronal (b) CT images show inflamed diverticula (arrows), segmental colonic wall thickening, and adjacent pericolic fat stranding. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

IV contrast-enhanced 2-mSv 4-mm-thick transverse and coronal (b) CT images show inflamed diverticula (arrows), segmental colonic wall thickening, and adjacent pericolic fat stranding. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

News | Computed Tomography (CT) | April 09, 2021
April 9, 2021 — According to an open-access article in ARRS' American Journal of Roentgenology (AJR), IV contrast-...
The Moscow Center for Diagnostics and Telemedicine presented clinical research findings during ECR 2021 highlighting that full integration of AI into radiology workflow during the pandemic increased radiologists' productivity
News | Artificial Intelligence | March 22, 2021
March 22, 2021 — Moscow Center for Diagnostics & Telemedicine and RADLogics shared the results of a large-scale...
WVU Rockefeller Neuroscience Institute staff prepare a patient for a first-in-the-world clinical trial to investigate the use of focused ultrasound technology to treat opioid use disorder. (WVU Photo/Brian Persinger)

WVU Rockefeller Neuroscience Institute staff prepare a patient for a first-in-the-world clinical trial to investigate the use of focused ultrasound technology to treat opioid use disorder. (WVU Photo/Brian Persinger)

News | Focused Ultrasound Therapy | March 17, 2021
March 17, 2021 — On the heels of the country’s deadliest year for drug overdoses, the West Virginia University...
Attending the two most recent screening appointments before a breast cancer diagnosis protects against breast cancer death, according to a Queen Mary University of London study of over half a million Swedish women conducted over 24 years

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News | Breast Imaging | March 12, 2021
March 12, 2021 — For women who had participated in both of their previous two screening examinations, the incidence of...
A new study by Rashi Mehta--a researcher with the WVU School of Medicine and Rockefeller Neuroscience Institute--finds that focused ultrasound may induce an immunological healing effect in the brains of Alzheimer's patients.

A new study by Rashi Mehta--a researcher with the WVU School of Medicine and Rockefeller Neuroscience Institute--finds that focused ultrasound may induce an immunological healing effect in the brains of Alzheimer's patients. Image courtesy of Caylie Silveria/West Virginia University

News | Focused Ultrasound Therapy | March 02, 2021
March 2, 2021 — West Virginia University scientists used magnetic resonance imaging (MRI) scans to show what happens...
Findings indicate that PPC and GG are highly predictive of overall upstaging by PSMA PET/CT for patients with high-risk prostate cancer

Image courtesy of UCLA Health

News | PET-CT | February 23, 2021
February 23, 2021 — A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center helps identify which...
F-18 FES PET images of patients with ER+/PR+/HER2- invasive ductal carcinoma. Left panel: Progressive disease seen at the 8-week time-point in a patient on sequential therapy. Right panel: Stable disease through all 3 time-points, remaining on study therapy for 6.7 months until disease progression on combined vorinostat aromatase inhibitor therapy. Image created by Lanell M Peterson, Research Scientist, University of Washington Medical Oncology, Seattle WA.

F-18 FES PET images of patients with ER+/PR+/HER2- invasive ductal carcinoma. Left panel: Progressive disease seen at the 8-week time-point in a patient on sequential therapy. Right panel: Stable disease through all 3 time-points, remaining on study therapy for 6.7 months until disease progression on combined vorinostat aromatase inhibitor therapy. Image created by Lanell M Peterson, Research Scientist, University of Washington Medical Oncology, Seattle WA.

News | Molecular Imaging | February 22, 2021
February 22, 2021 — Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-...
Axial FLAIR MR image shows T2 prolongation in bilateral middle cerebellar peduncles (arrows). Findings were associated with restricted diffusion and areas of T1 hypointense signal without enhancement or abnormal susceptibility. Image courtesy of American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

Axial FLAIR MR image shows T2 prolongation in bilateral middle cerebellar peduncles (arrows). Findings were associated with restricted diffusion and areas of T1 hypointense signal without enhancement or abnormal susceptibility. Image courtesy of American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

News | Coronavirus (COVID-19) | February 22, 2021
February 22, 2021 — According to an open-access article in ARRS' American Journal of Roentgenology (AJR), COVID-19-...
Example MR images from paediatric brain tumour patients. This first column shows T1-weighted images following the injection of gadolinium contrast agent. The second column shows T2-weighted images and the final column shows apparent diffusion coefficient maps calculated from diffusion-weighted images. (a–c) are taken from a patient with a Pilocytic Astrocytoma, (d–f) are from a patient with an Ependymoma and (g–i) were acquired from a patient with a Medulloblastoma.

Example MR images from paediatric brain tumour patients. This first column shows T1-weighted images following the injection of gadolinium contrast agent. The second column shows T2-weighted images and the final column shows apparent diffusion coefficient maps calculated from diffusion-weighted images. (ac) are taken from a patient with a Pilocytic Astrocytoma, (df) are from a patient with an Ependymoma and (gi) were acquired from a patient with a Medulloblastoma. Image courtesy of Nature Research Journal

News | Pediatric Imaging | February 17, 2021
February 17, 2021 — Diffusion weighted imaging and machine learning can successfully classify the diagnosis and...
T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.

T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.

News | Magnetic Resonance Imaging (MRI) | February 17, 2021
February 17, 2021 — A new paper, "Is it time to switch your T1W sequence? Assessing the impact of prospective motion...
Immunotherapy-based precision medicine clinical trials being developed

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News | Prostate Cancer | February 16, 2021
February 16, 2021 — Black men die more often of prostate cancer yet, paradoxically, have greater survival benefits from...
The research collaboration agreement covers a joint clinical retrospective study on liver fibrosis severity in Non-Alcoholic Steato-Hepatitis (NASH) patients
News | Artificial Intelligence | February 10, 2021
February 10, 2021 — Median Technologies announced the company has signed a research collaboration agreement with the...
Unhealthy lifestyles, various diseases, stress, and aging can all contribute to an imbalance between the production of ROS and the body's ability to reduce and eliminate them. The resulting excessive levels of ROS cause "oxidative stress".

Unhealthy lifestyles, various diseases, stress, and aging can all contribute to an imbalance between the production of ROS and the body's ability to reduce and eliminate them. The resulting excessive levels of ROS cause "oxidative stress". Graphic courtesy of National Institutes for Quantum and Radiological Science and Technology

News | Magnetic Resonance Imaging (MRI) | February 10, 2021
February 10, 2021 — Oxygen is essential for human life, but within the body, certain biological environmental...
Phase III clinical trial of men with a clinical suspicion of prostate cancer finds MRI with targeted biopsies to be more accurate at diagnosis and less intrusive than current standard
News | Magnetic Resonance Imaging (MRI) | February 08, 2021
February 8, 2021 — The results of a Phase III randomized clinical trial have shown that when it comes to detecting...
A study led by UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine shows that Black children are 18% less likely to get imaging tests as part of their emergency department visit compared to White children. Hispanic children are 13% less likely to have imaging done than Whites.

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News | Pediatric Imaging | February 03, 2021
February 3, 2021 — A study led by UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of...