Clinical Trials

Clinical trials and studies about imaging technology can be found on this channel.

Jeff Elias, MD, is a neurosurgeon at UVA Health and a pioneer in the field of focused ultrasound.

Jeff Elias, MD, is a neurosurgeon at UVA Health and a pioneer in the field of focused ultrasound. Image courtesy of UVA Health

News | Focused Ultrasound Therapy | January 08, 2021
January 8, 2021 — A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s...
World-first techniques for predicting breast cancer risk from mammograms that were developed in Melbourne could revolutionise breast screening by allowing it to be tailored to women at minimal extra cost

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News | Mammography | January 06, 2021
January 6, 2021 — World-first techniques for predicting breast cancer risk from mammograms that were developed in...
Now, researchers using magnetic resonance imaging (MRI) have found potential brain biomarkers of PTSD in people with traumatic brain injury (TBI).
News | Magnetic Resonance Imaging (MRI) | December 31, 2020
December 31, 2020 — Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder brought on by physical and/...
Differences in brain activity between connected and disconnected states of consciousness studied with positron emission tomography (PET) imaging. Activity of the thalamus, anterior (ACC) and posterior cingulate cortices (PCC), and bilateral angular gyri (AG) show the most consistent associa-tions with the state of consciousness (A = general anesthesia, B = sleep). The same brain struc-tures, which are deactivated when the state of consciousness changes to disconnected in general anesthesia or natural sleep

Differences in brain activity between connected and disconnected states of consciousness studied with positron emission tomography (PET) imaging. Activity of the thalamus, anterior (ACC) and posterior cingulate cortices (PCC), and bilateral angular gyri (AG) show the most consistent associa-tions with the state of consciousness (A = general anesthesia, B = sleep). The same brain struc-tures, which are deactivated when the state of consciousness changes to disconnected in general anesthesia or natural sleep (cool colors in the left columns), are reactivated when regaining a con-nected state upon emergence from anesthesia (warm colors in the right columns). Graphic courtesy of University of Turku

News | PET Imaging | December 30, 2020
December 30, 2020 — What happens in the brain when our conscious awareness fades during general anesthesia and normal...
Researchers at the University of Turku have discovered what type of neural mechanisms are the basis for emotional responses to music. Altogether 102 research subjects listened to music that evokes emotions while their brain function was scanned with functional magnetic resonance imaging (fMRI). The study was carried out in the national PET Centre.

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News | Magnetic Resonance Imaging (MRI) | December 30, 2020
December 30, 2020 — Researchers at the University of Turku have discovered what type of neural mechanisms are the basis...
Primary liver cancer is on the rise worldwide, largely due to an increase in hepatitis C infections and chronic liver disease

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News | Radiation Therapy | December 16, 2020
December 16, 2020 — Primary liver cancer is on the rise worldwide, largely due to an increase in hepatitis C infections...
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program #COVID19 #coronavirus

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News | Coronavirus (COVID-19) | December 07, 2020
December 7, 2020 — An analysis of lung tissues from patients with different types of pulmonary fibrosis - including...
16% of people believe they have developed a medical condition since the coronavirus crisis started but have not seen a doctor because they worry about getting COVID-19
News | Coronavirus (COVID-19) | December 07, 2020
December 7, 2020 — New research* from Zegami, an Oxford based medical image analysis platform, reveals that 29% of...
In this prototype design, no elements are placed over patient's eyes, nose, or mouth, which may improve comfort compared with conventional coils. In this image, identifiable portions of participant's face have been obscured for publication and privacy purposes. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

In this prototype design, no elements are placed over patient's eyes, nose, or mouth, which may improve comfort compared with conventional coils. In this image, identifiable portions of participant's face have been obscured for publication and privacy purposes. Image courtesy of the American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

News | Radiology Imaging | December 04, 2020
December 4, 2020 — According to an article in ARRS' American Journal of Roentgenology (AJR), a prototype 16-channel...
Generated heatmaps appropriately highlighted abnormalities in the lung fields in those images accurately labeled as COVID-19 positive (A-C) in contrast to images which were accurately labeled as negative for COVID-19 (D). Intensity of colors on the heatmap correspond to features of the image that are important for prediction of COVID-19 positivity. Image courtesy of Northwestern University

Generated heatmaps appropriately highlighted abnormalities in the lung fields in those images accurately labeled as COVID-19 positive (A-C) in contrast to images which were accurately labeled as negative for COVID-19 (D). Intensity of colors on the heatmap correspond to features of the image that are important for prediction of COVID-19 positivity. Image courtesy of Northwestern University

News | Artificial Intelligence | December 03, 2020
December 3, 2020 — Northwestern University researchers have developed a new artificial intelligence (AI) platform that...
An example of a body composition analysis of an abdominal CT slice with the subcutaneous fat in green, skeletal muscle red and visceral fat in yellow. This was automatically identified and analyzed via a deep learning algorithm to assess the risk for heart attack and stroke in more than 12,000 patients. #RSNA2020 #RSNA20 #RSNA

An example of a body composition analysis of an abdominal CT slice with the subcutaneous fat in green, skeletal muscle red and visceral fat in yellow. This was automatically identified and analyzed via a deep learning algorithm to assess the risk for heart attack and stroke in more than 12,000 patients.

Feature | Artificial Intelligence | December 02, 2020
December 2, 2020 – Automated deep learning analysis of abdominal computed tomography (CT) images produces a more...
 The study "Will We Solve Crimes with Radiomics? Results of an Experimental Study on Charred Human Bone Samples," was presented at the Virtual Radiological Society of North America's 2020 conference (RSNA20). Radiomics, which extracts data from clinical images, can be reliably used to assess changes in the bone structure due to fire exposure.
News | Computed Tomography (CT) | December 01, 2020
December 1, 2020 — The study "Will We Solve Crimes with Radiomics? Results of an Experimental Study on Charred Human...
Chest CT images in a 34-year-old man with fever for 4 days. Positive result of reverse-transcription polymerase chain reaction assay for severe acute respiratory syndrome coronavirus 2 using a swab sample was obtained on February 8, 2020. Dates of examination are shown on images. A, Chest CT scan with magnification of lesions in coronal and sagittal planes shows a nodule with reversed halo sign in left lower lobe (box) at the early stage of the pneumonia. B, Chest CT scans in different axial planes and coro

Chest CT images in a 34-year-old man with fever for 4 days. Positive result of reverse-transcription polymerase chain reaction assay for severe acute respiratory syndrome coronavirus 2 using a swab sample was obtained on February 8, 2020. Dates of examination are shown on images. A, Chest CT scan with magnification of lesions in coronal and sagittal planes shows a nodule with reversed halo sign in left lower lobe (box) at the early stage of the pneumonia. B, Chest CT scans in different axial planes and coronal reconstruction show bilateral multifocal ground-glass opacities. The nodular opacity resolved.

News | Coronavirus (COVID-19) | November 29, 2020
November 29, 2020 — The Radiological Society of North America (RSNA) presented its ninth Alexander R. Margulis Award...
The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation awarded the 2020 Bracco Diagnostics Inc./RSNA Research Scholar Grant to Brent D. Weinberg, M.D., Ph.D., and the 2020 Bracco Diagnostics Inc./RSNA Research Resident Grant to Evan DC Calabrese, M.D., Ph.D. These grants are made possible by Bracco Diagnostics Inc.’s support of the RSNA R&E Foundation.

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News | Radiology Business | November 03, 2020
November 3, 2020 — The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation...
Conceptual diagram of bio-organizational crushing technology based on high-intensity concentric ultrasonography. Image courtesy of Korea Institue of Science and Technology(KIST)

Conceptual diagram of bio-organizational crushing technology based on high-intensity concentric ultrasonography. Image courtesy of Korea Institue of Science and Technology(KIST)

News | Ultrasound Imaging | November 02, 2020
November 2, 2020 — Focusing ultrasound energy on a target site in the body to generate heat can burn and destroy the...
Updated results of NRG Oncology trial display effectiveness of gemcitabine and daily radiation for bladder preservation in muscle-invasive bladder cancer patients
News | Radiation Oncology | November 02, 2020
November 2, 2020 — Bladder preservation with trimodality therapy can be a safe and effective alternative to cystectomy...
Evaluation of the lung apices using computed tomography angiography of the head and neck during acute ischemic stroke (AIS) can provide the first objective opportunity to screen for coronavirus disease 2019 (COVID-19)

Image courtesy of the American Heart Association

News | CT Angiography (CTA) | October 30, 2020
October 30, 2020 — Computed tomography angiogram (CTA) scans may offer fast and early detection of COVID-19 in acute...
José Obeso, MD, PhD, (left) of of the Centro Integral de Neurociencias (HM CINAC) in Madrid and Nir Lipsman, MD, PhD, (right) of Sunnybrook Health Sciences Centre in Toronto. Each doctor is leading a clinical trial using focused ultrasound to target the striatum in patients with Parkinson's disease.

José Obeso, MD, PhD, (left) of of the Centro Integral de Neurociencias (HM CINAC) in Madrid and Nir Lipsman, MD, PhD, (right) of Sunnybrook Health Sciences Centre in Toronto. Each doctor is leading a clinical trial using focused ultrasound to target the striatum in patients with Parkinson's disease.

News | Focused Ultrasound Therapy | October 30, 2020
October 30, 2020 — A team of researchers in Madrid, Spain, and another team in Toronto, Canada, are the first in the...
An example of a HeartFlow FFR-CT image showing the blood flow through what looked like a significant blockage on CT angiography alone, actually was not flow-limiting based on computational fluid dynamics. Use of the technology was supposed to reduce the number of diagnostic catheterizations in the FORECAST trial, but the costs of FFR-CT were not offset enough to show cost savings.

An example of a HeartFlow FFR-CT image showing the blood flow through what looked like a significant blockage on CT angiography alone, actually was not flow-limiting based on computational fluid dynamics. Use of the technology was supposed to reduce the number of diagnostic catheterizations in the FORECAST trial, but the costs of FFR-CT were not offset enough to show cost savings.

Feature | CT Angiography (CTA) | October 23, 2020
October 22, 2020 – In the FORECAST randomized clinical trial, the use of fractional flow reserve (FFR) derived from...
This illustration show the complexity of the data obtained from one single patient with moderate/severe traumatic brain injury. Different imaging approaches and techniques have their own unique sensitivity in assessing different aspects of neuroanatomy and neuropathology. What can be seen on images also changes with time since injury. Data from comprehensive clinical and functional assessments using a range of other tools is also important for evaluating patient outcome. Through data harmonization and large

This illustration show the complexity of the data obtained from one single patient with moderate/severe traumatic brain injury. Different imaging approaches and techniques have their own unique sensitivity in assessing different aspects of neuroanatomy and neuropathology. What can be seen on images also changes with time since injury. Data from comprehensive clinical and functional assessments using a range of other tools is also important for evaluating patient outcome. Through data harmonization and large-scale analyses of data combined across multiple research sites, the ENIGMA Brain Injury will develop and test methods and procedures for making sense of the complexity in this data. Images courtesy of Olsen et al., Brain Imaging and Behavior, 2020

News | Magnetic Resonance Imaging (MRI) | October 23, 2020
October 23, 2020 — Traumatic brain injury is a major cause of disability and can have major consequences for patients...