News | February 27, 2014

Alzheimer's Disease Early Detection Possible in People with two Diagnosed Parents

Alzheimer's Disease Clinical Trial/Study PET Systems MRI

February 27, 2014 — People who are dementia-free but have two parents with Alzheimer's disease may show signs of the disease on brain scans decades before symptoms appear, according to a new study published in Neurology.

"Studies show that by the time people come in for a diagnosis, there may be a large amount of irreversible brain damage already present," said study author Lisa Mosconi, Ph.D., with the New York University School of Medicine in New York. "This is why it is ideal that we find signs of the disease in high-risk people before symptoms occur."

For the study, 52 people between the ages of 32 and 72 and free of dementia underwent several kinds of brain scans, including positron emission tomography (PET) and magnetic resonance imaging (MRI) scans. PET scans measure the amount of brain plaques as well as overall brain activity, such as brain metabolism. MRI scans look at brain structure and possible reductions in brain volume. Participants were split into four groups of 13 people: those with a mother with Alzheimer's disease, a father, both parents or no family history of the disease.

People with both parents who had Alzheimer's disease showed more severe abnormalities in brain volume, metabolism and five to 10 percent increased brain plaques in certain brain regions compared to the other three groups.

"Our study also suggests that there might be genes that predispose individuals to develop brain Alzheimer's pathology as a function of whether one parent or both parents have the disease," Mosconi said. "We do not yet know which genes, if any, are responsible for these early changes, and we hope that our study will be helpful to future genetic investigations."

People whose mother had Alzheimer's disease showed a greater level of the Alzheimer's disease biomarkers in the brain than people whose father had the disease, which is consistent with previous studies showing that people whose mothers had the disease were more likely to develop it than those with fathers with the disease, Mosconi said. She noted the small sample size of the study.

For more information: www.aan.com

Related Content

A brain MRI. Gadolinium contrast agents (GBCAs) are partly retained in the brain, raising safety concerns.
Feature | Magnetic Resonance Imaging (MRI) | February 16, 2018 | Dave Fornell
One of the biggest concerns in radiology in recent years is the safety of gadolinium-based contrast agents (GBCAs) us
Arterys Receives First FDA Clearance for Oncology Imaging Suite With Deep Learning
Technology | Artificial Intelligence | February 15, 2018
February 15, 2018 — Arterys Inc. announced its fifth 510(k) clearance from the U.S.
AHRA and Canon Medical Systems Announce 2017 Putting Patients First Grant Winners
News | Patient Engagement | February 14, 2018
The Association for Medical Imaging Management (AHRA) and Canon Medical Systems recently announced the tenth annual...
Videos | Pediatric Imaging | February 14, 2018
ITN Associate Editor Jeff Zagoudis demonstrates several mobile apps designed to help pediatric patients learn what an
Patients Lack Information About Imaging Exams
News | Patient Engagement | February 14, 2018
Patients and their caregivers desire information about upcoming imaging examinations, but many are not getting it,...
Vantage Galan 3T XGO Edition MRI system was cleared by the FDA.
Technology | Magnetic Resonance Imaging (MRI) | February 12, 2018
February 12, 2018 — Physicians now have access to more neuro and cardiac...
PSMA PET-CT Clearly Differentiates Prostate Cancer from Benign Tissue

68Ga-PSMA PET/CT images showing multifocal PCA in peripheral zone with GS of 5 1 5 5 10. (A and C) Axial PET images. (B and D) Fused PET/CT images. SUVmax of lesion in B was 84.3 and that of lesion in D was 5.7. IRS was 3, and 80% of cells were stained. Credit: Senior author V Prasad, Charité Universitätsmedizin Berlin, Berlin, Germany.

News | PET-CT | February 05, 2018
February 5, 2018 — Using nuclear medicine...
MedyMatch Receives FDA Device Designation for Intracranial Hemorrhage Software
News | Computed Tomography (CT) | February 01, 2018
February 1, 2018 – MedyMatch Technology, a company focused on helping physicians provide accurate patient assessment
Machine Learning Techniques Generate Clinical Labels of Medical Scans
News | Artificial Intelligence | January 31, 2018
Researchers used machine learning techniques, including natural language processing algorithms, to identify clinical...
Overlay Init