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How the bent crystal changes the direction of the X-rays. Image courtesy of Tohoku University

Colored areas of the brain represent regions where the loss of brain synapses in people with early-stage Alzheimer’s was greater than people with normal cognitive function. Image courtesy of YaleNews.

Experimental Protocol and Representative MRI of Brains at Various Key Points in That Protocol. (A) Experimental timeline. (B) Representative T2WI (using an 11.7T MRI) of the brain of a postnatal day (PND) 11 pup, 1 day after inducing left HII and prior to hNSC transplantation. Note the beginning of an increasingly intense “water signal” (white) on the left (“HII lesion”). (C) Representative T2WI (using an 11.7T MRI) 3 days post-HII, shortly after implantation of SPIO pre-labeled hNSCs into the contralateral cerebral ventricle (“Lateral Vent”). Note the “HII lesion” on the left becoming hyperintense (white) and the black signal void of the SPIO-labeled hNSCs in the lateral ventricle (black arrow). Red arrows denote the needle track. In contrast to what occurs in the intact brain (Figure S4), in a brain subjected to left HII, the implanted SPIO-labeled hNSCs (black signal void) (black arrow) migrate from the right (“R”) to the left (“L”) hemisphere to enter the lesion. (D and E) Shown here (using a 4.7T MRI) are SPIO-labeled hNSCs (black signal void) (black arrow) at 1 month post-implantation into the contralateral ventricle (D) and, in the same representative animal, at 3 months post-implantation (E)–stably integrated and surrounding a much-reduced residual lesion, with no interval enlargement of the graft or ventricles.

Maximum-intensity projections, transaxial fusion, and PET images of 18F-PSMA1007 (A-C) and 68Ga-PSMA-11 (D-F) PET/CT scans of 67-y-old patient with GS 8 and PSA 4.9 ng/mL. Marked uptake is seen in urinary bladder and left ureter (arrow) on maximum-intensity projection image of 68Ga-PSMA-11 (D), as opposed to nearly negligible 18F-PSMA-1007 urinary excretion (A). Dominant lesion in left prostatic lobe is evident on both scans (arrowheads). However, second lesion is seen in right lobe only on 18F-PSMA-1007 scan (arrow in C), later verified on pathology as true malignant lesion. Images created by J. Kuten et al., Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.