News | Neuro Imaging | July 11, 2017

MRI reveals changes that could help differentiate Parkinsonism disorders, track disease progression and monitor patient response to drug treatment

Researchers Identify Visual System Changes that May Signal Parkinson's Disease

July 11, 2017 — Changes in the visual systems of newly diagnosed Parkinson’s disease patients may provide important biomarkers for the early detection and monitoring of the disease, according to a new study published online in the journal Radiology.

“Just as the eye is a window into the body, the visual system is a window into brain disorders,” said lead researcher Alessandro Arrigo, M.D., a resident in ophthalmology at the University Vita-Salute San Raffaele of Milan, Italy.

Parkinson’s disease is a neurodegenerative condition caused by neuronal loss in several brain structures. Parkinson’s disease is characterized by tremors, rigidity or stiffness throughout the body, and impaired balance and coordination.

“Although Parkinson’s disease is primarily considered a motor disorder, several studies have shown non-motor symptoms are common across all stages of the disease,” Arrigo said. “However, these symptoms are often undiagnosed because patients are unaware of the link to the disease and, as a result, they may be under-treated.”

Non-motor symptoms experienced by patients with Parkinson’s disease include visual alterations such as an inability to perceive colors, a change in visual acuity, and a decrease in blinking which can lead to dry eye.

“These non-motor Parkinson’s symptoms may precede the appearance of motor signs by more than a decade,” Arrigo said.

The study of 20 newly diagnosed and not yet treated patients (11 men, 9 women) with Parkinson’s disease and 20 age- and gender-matched healthy controls involved a multi-disciplinary team of researchers in ophthalmology, neurology and neuroradiology of the University of Messina, Italy. Magnetic resonance imaging (MRI) was performed on both the healthy controls and the patients, who underwent imaging within four weeks of their diagnosis. Researchers used an MRI technique called diffusion weighted imaging to assess white matter changes and voxel-based morphometry (VBM) to investigate concentration changes of brain’s gray and white matter. All study participants also had ophthalmologic examinations.

The researchers found significant abnormalities within the visual system brain structures of Parkinson’s disease patients, including alterations of optic radiations, a reduction of white matter concentration and a reduction of optic chiasm volume. The optic chiasm is the part of the brain where the left and right optic nerves intersect.

“The study in depth of visual symptoms may provide sensitive markers of Parkinson’s disease,” Arrigo said. “Visual processing metrics may prove helpful in differentiating Parkinsonism disorders, following disease progression, and monitoring patient response to drug treatment.”

Arrigo added that future studies are needed to better understand the timing of degeneration along visual pathways, as well as the specific changes.

“We’re excited by our findings,” he said. “However, this is just a starting point.”

For more information: www.pubs.rsna.org/radiology

Related Content

News | Magnetic Resonance Imaging (MRI)

November 24, 2021 — Royal Philips announced new AI-enabled innovations in MR imaging launching at the Radiological ...

Time November 24, 2021
arrow
News | Coronavirus (COVID-19)

November 24, 2021 — Significant decreases in CT imaging for cancer persisted even after the peak of the COVID-19 ...

Time November 24, 2021
arrow
News | Magnetic Resonance Imaging (MRI)

November 23, 2021 — Researchers at Yale University analyzing specialized MRI exams found significant changes in the ...

Time November 23, 2021
arrow
News | Interventional Radiology

November 23, 2021 — A minimally invasive ablation procedure offers long-term relief for patients who experience chronic ...

Time November 23, 2021
arrow
News | Magnetic Resonance Imaging (MRI)

November 22, 2021 — Adolescents and young adults with post-concussive symptoms who suffered three to five concussions ...

Time November 22, 2021
arrow
News | Artificial Intelligence

November 18, 2021 — VIDA Diagnostics Inc. (VIDA) is further removing friction in respiratory clinical trials with the ...

Time November 18, 2021
arrow
News | Magnetic Resonance Imaging (MRI)

November 17, 2021 — The University of Michigan Health System recently became the first U.S. healthcare institution to ...

Time November 17, 2021
arrow
News | Radiation Therapy

November 17, 2021 — Radiation can be a powerful cancer therapy, but it doesn’t work for everyone. A new study identifies ...

Time November 17, 2021
arrow
News | Prostate Cancer

November 16, 2021 — A new Harvey L. Neiman Health Policy Institute study of nearly 800,000 men found that between 2011 ...

Time November 16, 2021
arrow
News | Digital Pathology

November 15, 2021 — Saltus Biotech, a leader in 8k image technology, introduces a new high-end computer workstation and ...

Time November 15, 2021
arrow
Subscribe Now