News | May 07, 2015

Redesigned MRI Systems May Increase Access for Patients With Implanted Devices

Massachusetts General-led team uses stealth technology to prevent excess heating of signal-carrying device leads

MRI, redesigned, implanted devices, pacemakers, MGH, Bonmassar, RTS

May 7, 2015 — New technology developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) may extend the benefits of magnetic resonance imaging (MRI) to many patients whose access to MRI is currently limited. A redesign of the wire at the core of the leads carrying signals between implanted medical devices and their target structures significantly reduces the generation of heat that occurs when standard wires are exposed to the radiofrequency (RF) energy used in MRI. The novel system is described in a paper published in the online Nature journal Scientific Reports.

"Clinical electrical stimulation systems such as pacemakers and deep-brain stimulators are increasingly common therapies for patients with a large range of medical conditions, but a significant limitation of these devices is restricted compatibility with MRI," says Giorgio Bonmassar, Ph.D., of the Martinos Center, senior and corresponding article of the paper. "The tests performed on our prototype deep-brain stimulation lead indicate a three-fold reduction in heat generation, compared with a commercially available lead; and the use of such leads could significantly expand how many patients may safely access the benefits of MRI."

For many years the primary limitation to the use of MRI in patients with implanted devices was the risk that the powerful magnetic fields would dislodge devices containing ferromagnetic (attracted by magnetic fields) metals, but the devices now available avoid using those metals. However, the RF energy used in MRI can increase the electrical current induced in the nonmagnetic metallic wires at the center of presently available device leads, producing heat that can damage tissues at the site where a stimulating signal is delivered. Even though the U.S. Food and Drug Administration (FDA) has authorized a group of "MR conditional" devices that can be used in some situations, those are limited to low-power scanners that cannot provide the information available from today's more powerful state-of-the-art MRI systems. It is estimated that around 300,000 patients worldwide are prevented from receiving MRI exams each year because of implanted devices.

The wires designed by the MGH/Martinos Center team use what is called resistive tapered stripline (RTS) technology that breaks up the RF-induced current increase by means of an abrupt change in the electrical conductivity of wires made from conductive polymers, a "cloaking" technique also used in some forms of stealth aircraft. After calculating the features required to produce an RTS lead that would minimize heat generation, the investigators designed and tested a deep-brain stimulation device with such a lead in a standard system used for MRI testing of medical implants - a gel model the size of an adult human head and torso. Compared with a commercially available lead, the RTS lead generated less than half the heat produced by exposure to a powerful MRI-RF field, a result well within current FDA limits.

Study co-author Emad Eskandar, M.D., of the MGH Department of Neurosurgery notes that the ability to conduct MR exams on patients with deep-brain stimulation implants would significantly improve the critical process of ensuring that the signal is being delivered to the right area, something that is not possible with computed tomography (CT) imaging. "For epilepsy patients and their providers, brain MRIs could provide much more accurate information about the sites where seizures originate and their relation to other brain structures, maximizing the effectiveness and improving the safety of implants that reduce or eliminate seizures. MR-compatible leads also would allow patients with brain implants to have MRIs of other parts of their body — knee, spine, breast — something that is currently prohibited," he said.

Bonmassar stressed that the team's RTS lead technology would be applicable to any type of active implant — including pacemakers, defibrillators and spinal cord stimulators. The research team is now pursuing an FDA Investigational Device Exemption that will allow clinical trials of devices with RTS leads. "The Obama administration's BRAIN initiative is sponsoring grant applications to study recording and/or stimulation devices to treat nervous system disorders and better understand the human brain," he said. "By pursuing these opportunities we hope that one day no patients will be denied access to state-of-the-art MRI examinations."

For more information: www.nmr.mgh.harvard.edu

Related Content

MRI Exablate neuro helmet from INSIGHTEC

MRI Exablate neuro helmet from INSIGHTEC. Image courtesy of Ali Rezai, M.D., and RSNA.

News | Clinical Trials | December 03, 2019
December 3, 2019 — Focused ultrasound is a safe and effective way to target and open areas of the blood-brain barrier
Reduction in fractional anisotropy (FA) in obese patients compared to the control group

Reduction in fractional anisotropy (FA) in obese patients compared to the control group: At the intersection of the alignment vectors, a large cluster of FA decrease located in the corpus callosum on the left. In red: Reduction of FA in obese patients compared to controls, and FA skeleton (green), superimposed on the mean of FA images in sample. Image courtesy of Pamela Bertolazzi, Ph.D., and RSNA.

News | Clinical Trials | November 25, 2019
November 25, 2019 — Researchers using magn...
Image by Volker Pietzonka from Pixabay

Image by Volker Pietzonka from Pixabay

News | Pediatric Imaging | November 25, 2019
November 25, 2019 — Connectivity in an area of the brain that regulates emotion may be altered in infants exposed to
Embrace Neonatal MRI is a U.S. Food and Drug Administration (FDA) cleared and CE marked compact magnetic resononance imaging (MRI) system ergonomically designed to fit inside the neonatal intensive care unit (NICU)
News | Magnetic Resonance Imaging (MRI) | November 25, 2019
November 25, 2019 — Embrace Neonatal MRI is a U.S.
FerrAlert technology automatically detects and logs ferromagnetic events and exclusively provides a photographic stream which is date and time stamped
News | Magnetic Resonance Imaging (MRI) | November 22, 2019
November 22, 2019 — Kopp Development Inc. acquired Mednovus, Inc.
The study finds it's possible to use commercial facial recognition software to identify people from brain MRI that includes imagery of the face
News | Magnetic Resonance Imaging (MRI) | November 15, 2019
November 15, 2019 — Though identifying data typically are removed from medical image files before they are shared for
An image on Brigham and Women's Hospital's 7T MRI system

An image on Brigham and Women's Hospital's 7T MRI system. Image courtesy of Brigham and Women's Hospital

News | Magnetic Resonance Imaging (MRI) | November 13, 2019
November 13, 2019 — Increased immune system activity along the surface of the brain, or meningeal inflammation, may b
Radiographer Apollo Exconde with his Lego concept open MRI for patient education.

Radiographer Apollo Exconde with his Lego concept open MRI for patient education.

News | Patient Engagement | November 11, 2019
November 11, 2019 — Radiographer Apollo Exconde...
Unlike other technologies for imaging the placenta, pCASL MRI can distinguish maternal blood from fetal blood

Image courtesy of Pixabay

News | Clinical Trials | November 07, 2019
November 7, 2019 — A new imaging technique to track