News | March 24, 2008

New PET-MRI Does Not Compromise Resolution, Signal

March 24, 2008 - Researchers have developed a three-dimensional scanner that combines positron emission tomography (PET) and magnetic resonance imaging (MRI), in which PET spatial resolution and signal sensitivity are not compromised and MRI images are not substantially affected.

"Both modalities preserve their functionality, even when operated isochronously," the team reports in the March 24th advance online publication of Nature Medicine.

Up until now, attempts to combine the two technologies permitted only sequential data acquisition in stand-alone systems and subsequent image fusion, limiting accuracy and reproducibility. Combining PET and MRI in one system is challenging, as regular PET detectors and photomultiplier tubes are sensitive to magnetic fields.

"We are using new avalanche photodiodes (with compact silicon light sensors), which are completely based on a semiconductor structure and show therefore no interaction with the magnetic field," Bernd J. Pichler, M.D., explained in correspondence with Reuters Health.

Using mice, Dr. Pichler, at Eberhard Karls University of Tubingen in Germany, and colleagues demonstrated the complementary information that can be obtained simultaneously, such as tumor-cell proliferation and tumor necrosis and inflammation.

"The combined PET-MRI information might make histology redundant for some applications, especially for longitudinal studies of disease progression or therapy response performed in the same subject," the authors said.

They were also able to obtain PET images simultaneously with MR spectroscopic information and functional MRI data.

"I think PET/MRI is great for studies in oncology and immunology where you want to detect cells in lymph nodes or where you need good morphological information along with your PET signal," Dr. Pichler said. "Other big applications will be cardiology, where you have the advantage of simultaneous data acquisition to avoid cardiac motion artefacts, and neurology, where you can correlate different information (eg, temporal correlation of blood flow with metabolism or receptor expression)."

He noted that his team's new design for a small animal scanner is nearly ready for commercial manufacture. "We are talking with companies," he said.

"We have already a prototype human PET-MRI in Tubingen, but this is not as mature as the animal system yet," the researcher added. "It requires many more PET detectors that need to be stabilized, and we need to have all approvals for clinical applications in place. I think within the next two to three years, we will have PET/MRI scanners clinically available."

Source: Nat Med 2008 and Reuters Health

For more information: www.nature.com

Related Content

Ingenia Ambition X 1.5T MR. This innovation is the latest advance in the Ingenia MRI portfolio, which comprises fully-digital MRI systems, healthcare informatics and a range of maintenance and life cycle services for integrated solutions that empower a faster, smarter, and simpler path to enabling a confident diagnosis
News | Magnetic Resonance Imaging (MRI) | September 14, 2018
Philips, a global leader in health technology, launched the Ingenia Ambition X 1.5T MR.
Lightvision near-infrared fluorescence imaging system
News | Women's Health | September 11, 2018
Shimadzu Corp.
Veye Chest version 2
News | Lung Cancer | September 11, 2018
Aidence, an Amsterdam-based medical AI company, announced that Veye Chest version 2, a class IIa medical device, has
Sponsored Content | Case Study | Magnetic Resonance Imaging (MRI) | September 07, 2018 | By Sabine Sartoretti, M.D.
As soon as the Compressed SENSE technology became available to the MRI team at Kantonsspital Winterthur (Switzerland),...
The Siemens Biograph Vision PET-CT system was released in mid-2018.

The Siemens Biograph Vision PET-CT system was released in mid-2018.

Feature | Nuclear Imaging | September 07, 2018 | By Dave Fornell
Nuclear imaging technology for both single photon emission computed tomography (SPECT) and positron emission tomography...

Image courtesy of Philips Healthcare

Feature | Magnetic Resonance Imaging (MRI) | September 06, 2018 | By Melinda Taschetta-Millane
According to the Prescient & Strategic Intelligence report, “Global Magnetic Resonance Imaging (MRI) Market Size,...
PET Imaging Agent Predicts Brain Tau Pathology, Alzheimer's Diagnosis
News | PET Imaging | September 05, 2018
Eli Lilly and Co. and Avid Radiopharmaceuticals Inc. announced a Phase 3 study of positron emission tomography (PET)...
Brain Iron Levels May Predict Multiple Sclerosis Disabilities
News | Neuro Imaging | August 31, 2018
A new, highly accurate magnetic resonance imaging (MRI) technique can monitor iron levels in the brains of multiple...
Study Finds Multiple Sclerosis Drug Slows Brain Shrinkage

An NIH-funded clinical trial suggested that the anti-inflammatory drug ibudilast may slow brain shrinkage caused by progressive MS. Image courtesy of Robert J. Fox, M.D., Cleveland Clinic.

News | Neuro Imaging | August 30, 2018
August 30, 2018 — Results from a clinical...
Rapid Cardiac MRI Technique May Cut Costs, Boost Care in Developing World
News | Magnetic Resonance Imaging (MRI) | August 29, 2018
A newly developed rapid imaging protocol quickly and cheaply diagnosed heart ailments in patients in Peru, according to...
Overlay Init