News | Artificial Intelligence | March 24, 2021

The software provides automated assessment of CF lung disease in seconds

Thirona, an artificial intelligence (AI) software company specialising in medical image analysis, developed an AI algorithm that revolutionizes cystic fibrosis (CF) care. The new algorithm, coined PRAGMA-AI, allows for fast, automated analysis of CT scans of patients with CF to detect and quantify lung abnormalities related to CF

March 24, 2021 — Thirona, an artificial intelligence (AI) software company specialising in medical image analysis, developed an AI algorithm that revolutionizes cystic fibrosis (CF) care. The new algorithm, coined PRAGMA-AI, allows for fast, automated analysis of CT scans of patients with CF to detect and quantify lung abnormalities related to CF. These quantifications are critical in determining the status of the patient and determine optimal treatment paths but are not feasible to be performed by humans in clinical care. The release of PRAGMA-AI paves the way for large-scale usage in clinical trials and clinical care for better diagnostics, patient monitoring, and treatment planning.

Assessment in seconds

CF is a rare genetic disorder with approximately 70,000 known cases worldwide, characterized by severe lung problems and reduced life expectancy. To help decide on appropriate care, clinical experts previously developed PRAGMA-CF, a quantitative method for assessment of CF lung disease on CT scans. But PRAGMA-CF is time consuming, taking up to several hours per patient and requiring highly trained data analysts – an infeasible task in a clinical setting. Medical AI software company Thirona, which also works on diseases like COPD, asthma, and tuberculosis, has now automated this method with far reaching potential for patient care. Their solution can analyze CT scans of CF patients in several seconds, without human interference.

High diagnostic performance

The new AI-based algorithm PRAGMA-AI, part of Thirona’s lung quantification software package LungQ, automatically identifies lung abnormalities related to CF, such as abnormal airways and collapsed lung tissue. These measurements supply sensitive and objective information on the pattern and extent of CF lung disease. This is critical information, allowing clinicians to monitor disease progression and supporting clinical decision-making for treatment plans. LungQ PRAGMA-AI has been validated on a large number of scans of CF patients, showing high diagnostic performance comparable to trained human analysts.

Search for new treatments

These developments pave the way for using the PRAGMA method in both clinical trials and clinical care. Prof. Harm Tiddens from Erasmus Medical Center, who co-developed the original PRAGMA-CF method, is proud to see the method automated. “It allows for large scale investigation of CF lung disease in both research studies and clinical trials. This is a crucial component in the evaluation of new expensive treatment options for patients suffering from CF,” said Tiddens. He further explained: “CF patient registries, collecting information on the health status of CF patients, have already shown interest in the PRAGMA-AI method. They use patient information to create care guidelines, drive quality improvement, and to study CF treatments and outcomes.”

For more information: www.thirona.eu


Related Content

News | Digital Radiography (DR)

February 8, 2023 — Carestream Health is partnering with Robarts Research Institute to increase and demonstrate the ...

Time February 08, 2023
arrow
News | Coronavirus (COVID-19)

February 8, 2023 — New data published in the Journal of Clinical Oncology further quantify the vast lingering impact of ...

Time February 08, 2023
arrow
Videos | Information Technology

A discussion on macro trends and the future of medical imaging with Jef Williams, managing partner, Paragon Consulting ...

Time February 07, 2023
arrow
News | Radiation Therapy

February 6, 2023 — Varian, a Siemens Healthineers company, announced that it has received 510(k) clearance from the U.S ...

Time February 06, 2023
arrow
News | Radiology Business

February 2, 2023 — Five additional imaging centers across Allegheny Health Network (AHN) have been recognized by the ...

Time February 02, 2023
arrow
Feature | Radiology Business | By Melinda Taschetta-Millane

Here is a recap of what ITN viewers found most interesting during the month of January: 1. A Look at the Changes in 2023 ...

Time February 01, 2023
arrow
News | PET Imaging

January 31, 2023 — Electronic cigarette (e-cigarette) users have greater lung inflammation than cigarette smokers and ...

Time January 31, 2023
arrow
News | Ultrasound Imaging

January 31, 2023 — Esaote, a leading Italian company in the biomedical sector – in ultrasound, dedicated MRI and medical ...

Time January 31, 2023
arrow
Webinar | Information Technology

Postpandemic staffing shortages and increased volumes require radiologists to do more with less, exacerbating burnout ...

Time January 30, 2023
arrow
News | Digital Pathology

January 27, 2023 — Fujifilm has completed its asset purchase of Inspirata, Inc.’s digital pathology business effective ...

Time January 27, 2023
arrow
Subscribe Now