News | February 03, 2015

Targeted MRI/Ultrasound Beats Standard Biopsy to Detect High-Risk Prostate Cancer

University of Maryland School of Medicine physician-scientist is lead author on NIH study of more than 1,000 men

MRI Systems, Ultrasound, Prostate cancer, JAMA, University of Maryland

M. Minhaj Siddiqui, M.D.

February 3, 2015 — Targeted biopsy using new fusion technology that combines magnetic resonance imaging (MRI) with ultrasound is more effective than standard biopsy in detecting high-risk prostate cancer, according to a large-scale study published today in JAMA. More than 1,000 men participated in the research at the National Institutes of Health (NIH) over a seven-year period.

Researchers found that 30 percent more high-risk prostate cancers were diagnosed with targeted fusion-guided biopsy than with standard biopsy. In addition, 17 percent fewer low-risk cancers were diagnosed with the new approach, compared to the older method. In a targeted biopsy, MRIs of the suspected cancer are fused with real-time ultrasound images, creating a map of the prostate that enables doctors to pinpoint and test suspicious areas. In a standard biopsy, doctors use ultrasound guidance to take multiple random tissue samples from throughout the gland. Unlike other cancers, such as breast cancer, which can be detected through mammograms, prostate cancer is not generally diagnosed using advanced imaging.

“This study demonstrates that targeted fusion-guided biopsy could significantly enhance our ability to identify patients with high-risk prostate cancers that need more aggressive treatment,” says lead author Mohummad Minhaj Siddiqui, M.D., assistant professor of surgery at the University of Maryland School of Medicine and director of urologic robotic surgery at the University of Maryland Marlene and Stewart Greenebaum Cancer Center. Siddiqui was a fellow at NIH when the study was conducted.

“With fusion technology, we now have a tool to help us differentiate high-risk cancers from low-risk ones that may require minimal or no treatment,” Siddiqui says. “There is a concern that we over-diagnose and over-treat low-risk cancers that are unlikely to be terminal, and this technology enables us to make a more reliable diagnosis than the current standard practice.”

But he adds, “While these findings could translate into substantial benefit to patients, this study is preliminary with regard to clinical endpoints such as recurrence of disease and prostate cancer-specific mortality.” Siddiqui says randomized clinical trials will be needed to determine the impact of targeted biopsy on clinical outcomes.

E. Albert Reece, M.D., Ph.D., MBA, vice president for medical affairs at the University of Maryland and the John Z. and Akiko K. Bowers distinguished professor and dean of the University of Maryland School of Medicine, says, “This study demonstrates that the MRI/ultrasound fusion biopsy technique offers benefits when compared to the current standard of care to diagnose clinically significant prostate cancer. Although further research is needed, this method holds promise, especially for diagnosing men with high-grade, aggressive cancers that may go undetected. Siddiqui is actively pursuing new research initiatives to bring fusion-guided biopsy into the clinical setting.”

Siddiqui plans to use MRI/ultrasound fusion in a clinical trial to identify and biopsy questionable areas within the prostate. In cases where treatment can be deferred, he will use this technology to perform more reliable active surveillance of prostate cancer requiring fewer biopsies. If the disease requires treatment and isn’t widespread, he will use focal brachytherapy – implanted radioactive seeds – to irradiate only the tumor, sparing the surrounding tissue. For patients with early-stage cancer this option avoids many of the side effects associated with removing the prostate or irradiating the entire gland. In more severe cases, the MRI can help guide more aggressive options such as robotic surgery.

Prostate cancer is highly curable, with a 94 percent 15-year relative survival rate for early stages. It is often diagnosed after blood tests show elevated prostate-specific antigen (PSA), but the PSA test has come increasingly under fire for being unreliable. Due to an inability to differentiate aggressive cancers from nonaggressive types, physicians treat the majority of cases, which may lead to side effects such as impotence and/or incontinence. Treatments include surgery to remove the prostate, radiation therapy and active surveillance during which patients are continuously monitored. Most men diagnosed with prostate cancer have a nonaggressive form of the disease, with tumors that grow very slowly – so slowly that the men may never experience any cancer-related complications and die from other causes.

The study of 1,003 men was conducted at the NIH in Bethesda, Md., from 2007-2014, with Peter A. Pinto, M.D., the head of the prostate cancer section of the urologic oncology branch, serving as the senior investigator. The participants were referred for biopsy because of elevated PSA or an abnormal digital rectal exam. They received targeted and concurrent standard biopsies.

Researchers noted that 461 prostate cancer cases were diagnosed with targeted biopsy versus 469 cases with standard biopsy. Targeted and standard biopsies produced the same results in 69 percent of the cases. But the scientists found that 30 percent more high-risk cancers – those that doctors want to detect – were diagnosed through targeted biopsy than standard biopsy (173 versus 122 cases) and 17 percent fewer low-risk cancers – those that are often over-diagnosed and over-treated (213 versus 258). Adding standard biopsy to targeted biopsy led to a 22 percent increase in cancer diagnoses, the vast majority of them for low-risk cancers.

Researchers also found that targeted biopsy was better able to predict whether the disease was low- or intermediate risk than standard biopsy or the two approaches combined. They were able to make that determination by comparing biopsied tissue with tissue taken from a patient’s prostate after it was later surgically removed.

Comparison of MRI-Ultrasound Fusion-Guided Biopsy with Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer

M. Minhaj Siddiqui, M.D., Soroush Rais?Bahrami, M.D., Baris Turkbey, M.D., Arvin George, M.D., Jason Rothwax, Nabeel Shakira, Chino Okoroa, Dima Raskolnikova, Howard L. Parnes, M.D., W. Marston Linehan, M.D., Maria J. Merino, M.D., Richard M. Simon, Ph.D., Peter L. Choyke, M.D., Bradford J. Wood, M.D. and Peter A. Pinto, M.D.

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