News | SPECT Imaging | March 16, 2021

NorthStar poised to be first commercial-scale supplier of important therapeutic radioisotopes Copper-67 (Cu-67) and Actinium-225 (Ac-225); Initial specialized SPECT imaging portfolio includes fibrin-targeted FibroScint, with potential indications in cardiovascular disease

NorthStar poised to be first commercial-scale supplier of important therapeutic radioisotopes Copper-67 (Cu-67) and Actinium-225 (Ac-225); Initial specialized SPECT imaging portfolio includes fibrin-targeted FibroScint, with potential indications in cardiovascular disease

March 16, 2021 — NorthStar Medical Radioisotopes, LLC announced organizational changes to drive focused growth for its therapeutic and specialized single photon emission computed tomography (SPECT) radioisotopes business. The new structure enables NorthStar to advance its efforts in radioisotope development and commercialization planning in parallel with its ongoing expansion programs for increased U.S. molybdenum-99 (Mo-99) capacity and production.

In conjunction with other organizational changes, NorthStar has appointed Dave Wilson, RPh., BCNP, as Vice President, Advanced Radiopharmaceutical and Therapeutic Technologies. He will have responsibility to advance NorthStar’s Copper-67 (Cu-67), Actinium-225 (Ac-225) and FibroScint programs to commercialization. Wilson, a five-year veteran at NorthStar, was previously Vice President, Commercial Operations for the Company, and has more than 25 years of experience in cGMP radiopharmaceutical manufacturing and radiopharmaceutical operations.

NorthStar is poised to be the first commercial-scale supplier of the important therapeutic radioisotopes Cu-67 and Ac-225, used in nuclear medicine to directly target and deliver therapeutic doses of radiation to destroy cancer cells in patients with serious disease. Development of promising therapies has been severely constrained by current production technology limitations and resultant limited supply. NorthStar is applying its commercial-scale radioisotope production technology expertise to provide reliable Cu-67 and Ac-225 supply for use in advancing clinical research and for commercial radiopharmaceutical products. The company has agreements in place with several large pharmaceutical companies to provide clinical trial supply and commercial-scale quantities of Cu-67 and Ac-225.

NorthStar is also actively developing and growing its strategic portfolio of specialized SPECT radiopharmaceuticals to meet increasing clinical needs for SPECT imaging, driven by scientific advancements in cardiology and oncology. NorthStar has an exclusive, global licensing agreement with Capella Imaging, Inc. for FibroScint, a novel fibrin-specific diagnostic imaging agent labeled with the radioisotope technetium-99m (Tc-99m) for SPECT imaging. Pending successful development, FibroScint will have an initial application in the imaging of thrombus (blood clots) associated with left ventricular assist devices (LVADs). Other potential imaging applications include deep vein thrombosis and pulmonary embolism. Preclinical development of FibroScint is well underway, with an exploratory Investigational New Drug filing planned for later in 2021.

“NorthStar is now optimally positioned for continued growth and success in developing and delivering on our portfolio of medical radioisotopes to meet the needs of patients and advance clinical research,” said Stephen Merrick, President and Chief Executive Officer of NorthStar Medical Radioisotopes. “With a dedicated focus to developing commercial-scale production technologies for Cu-67 and Ac-225 radioisotopes, we can bring much-needed therapies to patients and researchers. The proven expertise and innovative approach as demonstrated in the successful development and commercialization of U.S.-produced, non-uranium based Mo-99 and the RadioGenix® System (technetium Tc-99 generator) will be brought to our therapeutic radioisotope programs.

Merrick continued, “We are also evaluating additional potential opportunities in specialized SPECT radiopharmaceuticals, with an eye to addressing unmet healthcare needs and synergies with our product portfolio. FibroScint has the potential to inform the management of multiple serious cardiovascular conditions, and complements the RadioGenix System in that we intend to use RadioGenix System-produced Tc-99m as we advance the compound into clinical studies.”

NorthStar is the only commercial producer of Mo-99 in the United States, having provided more than two years of stable U.S. production to date, and continues ongoing activities to expand U.S.-Mo-99 capacity and production. The Company is nearing completion of its Accelerator Production facility in Beloit, Wisconsin. This will ensure continued domestic Mo-99 supply for the United States through dual production and processing hubs for additional capacity and scheduling flexibility. The expansion of this facility will augment current processing in Columbia, Missouri to continue joint production of Mo-99 in partnership with the University of Missouri Research Reactor (MURR).

For more information:

Related Tc-99m Content: 

How Nuclear Fusion is Revolutionizing Medical Isotope Production

FDA Approves Additional Molybdenum-99 (Mo-99) Filling Lines at NorthStar Medical Radioisotopes

Medical Isotope Industry Opposes Export of Highly Enriched Uranium for IRE

IBA and NorthStar Medical Radioisotopes Expand Collaboration to Enable Global Availability of Tc-99m

Related Content

News | Computed Tomography (CT)

November 28, 2021 — Detection Technology, a leader in X-ray detector solutions, unveiled the industry’s first off-the ...

Time November 28, 2021
News | Magnetic Resonance Imaging (MRI)

November 24, 2021 — Royal Philips announced new AI-enabled innovations in MR imaging launching at the Radiological ...

Time November 24, 2021
News | Artificial Intelligence

November 23, 2021 — The results of a unique two-tiered brain tumor AI challenge were announced today by the Radiological ...

Time November 23, 2021
News | Radiology Business

November 23, 2021 — Guerbet LLC, the U.S. affiliate of Guerbet, a global leader in medical imaging, is pleased to be ...

Time November 23, 2021
News | Radiology Imaging

November 22, 2021 — Guerbet LLC, the U.S. affiliate of Guerbet, a global leader in medical imaging, was awarded a ...

Time November 22, 2021
News | Nuclear Imaging

November 22, 2021 — IBA, a leader in particle accelerator technology, and NorthStar Medical Radioisotopes LLC, a global ...

Time November 22, 2021
News | RSNA

November 22, 2021 — The Radiological Society of North America (RSNA) announced that more than 19,000 attendees are ...

Time November 22, 2021
News | X-Ray

November 19, 2021 — Carestream Health will showcase its innovations in mobile medical imaging with the Ziehm Vision RFD ...

Time November 19, 2021
News | Ultrasound Imaging

November 18, 2021 — Royal Philips, a leader in health technology, announced it has received 510(k) clearance from the U ...

Time November 18, 2021
News | Mobile C-Arms

November 17, 2021 — Fujifilm Healthcare Americas, a leading provider of diagnostic imaging and medical informatics ...

Time November 17, 2021
Subscribe Now