News | Magnetic Resonance Imaging (MRI) | May 17, 2018

MRI "Glove" Provides New Look at Hand Anatomy

Wearable MRI detector captures motion for first time; creates potential for injury diagnosis

MRI "Glove" Provides New Look at Hand Anatomy

An experiment showed that a glove-shaped detector could yield images of bones, cartilage, and muscles interacting as a hand 'plays piano.' Traditionally, MRI had required patients to remain strictly motionless.Image courtesy of Nature Biomedical Engineering; Bei Zhang, Martijn Cloos, Daniel Sodickson

May 17, 2018 — A new kind of magnetic resonance imaging (MRI) component in the shape of a glove delivers the first clear images of bones, tendons and ligaments moving together, a new study finds.

Led by NYU School of Medicine and just published in Nature Biomedical Engineering, the study shows how a new MRI element design woven into garment-like detectors can capture high-quality images of moving joints for the first time.

The study authors say their MRI glove prototype promises to become useful in the future diagnosis of repetitive strain injuries like carpal tunnel syndrome in office workers, athletes and musicians. Because the invention shows how different tissue types impinge on each other as they move, the authors say it could also enable the construction of a more versatile atlas of hand anatomy, guide surgery with hand images in more realistic positions, or aid in the design of better prosthetics.

"Our results represent the first demonstration of an MRI technology that is both flexible and sensitive enough to capture the complexity of soft-tissue mechanics in the hand," said lead author Bei Zhang, Ph.D., research scientist at the Center for Advanced Imaging Innovation and Research (CAI2R), within the Department of Radiology at NYU Langone Health.

Since its emergence in the 1970s, MRI has given physicians a better look inside tissues, helping to diagnose millions of maladies per year, from brain tumors to internal bleeding to torn ligaments. Despite this impact, the technology has long struggled with a basic limitation.

MRI works by immersing tissues in a magnetic field such that any hydrogen atoms present align to create an average magnetic force in one direction in each tissue slice. These "little magnets" can then be tipped out of equilibrium by waves of electromagnetic force (radio waves). Once tipped, they spin like tops and also emit radio signals, which reveal their positions and can be rebuilt into images.

Also fundamental to MRI is the ability of radiofrequency coils to convert radio waves into a detectable electric current. Unfortunately, this means that the captured ("spinning top") radio waves produce little currents inside receiver coils, which in turn create their own magnetic fields and prevent nearby coils from capturing clean signals.

Over the last 30 years, attempts to manage interactions between neighboring coils have resulted in state-of-the-art MRI scanners in which receiver coils are painstakingly arranged to cancel out magnetic fields in neighboring coils. Once the best arrangement is set, coils can no longer move relative to one another, constraining the ability of MRI to image complex, moving joints.

As all current MRI scanners measure signals that create currents in receiver coils (detectors), such coils have always been designed as "low impedance" structures that let the current flow easily. The leap made by the study authors was to design a "high impedance" structure that blocks current, and then measures how hard the force in magnetic waves "pushes" (the voltage) as it attempts to establish a current in the coil.

With no electric current created by the MR signal, the new receiver coils no longer create magnetic fields that interfere with neighboring receivers, thus removing the need for rigid structures. The researchers found that their system, with the new coils stitched into a cotton glove, generated "exquisite" images of freely moving muscles, tendons and ligaments in a hand as it played piano and grabbed objects.

The MRI signal is produced by hydrogen atoms (protons), and so this technology excels at imaging soft tissue structures rich in water, each molecule of which includes two atoms of hydrogen. For this reason, MRI is great at imaging muscles, nerves and even cartilage, which are difficult to study using other non-invasive methods. Tendons and ligaments, however, which are made of dense proteins instead of fluid, remain difficult to see independently, because both appear as black bands running alongside bone.

The new study found that, in visualizing fingers as they flexed, the new coils revealed how the black bands moved in concert with the bones, which could help to catalog differences that come with injury.

"We wanted to try our new elements in an application that could never be done with traditional coils, and settled on an attempt to capture images with a glove," said senior author Martijn Cloos, Ph.D., assistant professor from the CAI2R institute in the Department of Radiology at NYU Langone Health. "We hope that this result ushers in a new era of MRI design, perhaps including flexible sleeve arrays around injured knees, or comfy beanies to study the developing brains of newborns."

Watch a video showing a hand playing piano while wearing the MRI glove.

For more information: www.nature.com/natbiomedeng

 

Related Content

Henry Ford Hospital's ViewRay MRIdian linear accelerator system allows real-time MRI-guided radiotherapy. Shown is the support staff for this system. In the center of the photo is Benjamin Movsas, M.D., chair of radiation oncology at Henry Ford Cancer Institute. Second from the right is Carrie Glide-Hurst, Ph.D., director of translational research, radiation oncology.

Henry Ford Hospital's ViewRay MRIdian linear accelerator system allows real-time MRI-guided radiotherapy. Shown is the support staff for this system. In the center of the photo is Benjamin Movsas, M.D., chair of radiation oncology at Henry Ford Cancer Institute. Second from the right is Carri Glide-Hurst, Ph.D., director of translational research, radiation oncology.

Feature | Henry Ford Hospital | May 21, 2019 | Dave Fornell, Editor
Henry Ford Hospital thought leaders regularly speak at the radiation oncology and radiology conferences about new res
Videos | Radiation Therapy | May 21, 2019
This is a walk through of the ViewRay MRIdian MRI-guided radiotherapy system installed at ...
360 Photos | Magnetic Resonance Imaging (MRI) | May 17, 2019
This is a dedicated cardiac Siemens 1.5T MRI system installed at the Baylor Scott White Heart Hospital in Dallas.
Miami Cardiac and Vascular Institute Implements Philips Ingenia Ambition X 1.5T MRI
News | Magnetic Resonance Imaging (MRI) | May 17, 2019
Miami Cardiac & Vascular Institute announced the implementation of Philips’ Ingenia Ambition X 1.5T MR, the world’s...
Managing Architectural Distortion on Mammography Based on MR Enhancement
News | Mammography | May 15, 2019
High negative predictive values (NPV) in mammography architectural distortion (AD) without ultrasonographic (US)...
Netherlands Hospital to Install State-of-the-Art MRI Ablation Center
News | Magnetic Resonance Imaging (MRI) | May 13, 2019
Imricor announced the signing of a commercial agreement with the Haga Hospital in The Hague, Netherlands to outfit a...
Screening MRI Detects BI-RADS 3 Breast Cancer in High-risk Patients
News | MRI Breast | May 09, 2019
When appropriate, short-interval follow-up magnetic resonance imaging (MRI) can be used to identify early-stage breast...
Clinical Trial Explores Opening Blood-Brain Barrier in Fight Against Alzheimer's

Vibhor Krishna, M.D., (right) fits David Shorr with a helmet-like device used in a new clinical trial for Alzheimer’s disease at The Ohio State University Wexner Medical Center. The device uses MRI-guided imaging to deliver focused ultrasound to specific areas of the brain to open the blood-brain barrier. Image courtesy of Ohio State University Wexner Medical Center.

News | Focused Ultrasound Therapy | May 09, 2019
May 9, 2019 — A new clinical trial at The Ohio State University Wexner Medical Center and two other sites is testing