News | Lung Cancer | May 02, 2017

Men Need More Frequent Lung Cancer Screening Than Women

European study suggests lung CT scans every 2-3 years would be sufficient for women

Men Need More Frequent Lung Cancer Screening Than Women

May 2, 2017 — Men need more frequent lung cancer screening than women, according to research presented at the European Lung Cancer Conference (ELCC).1

The U.S. Preventive Services Task Force recommends annual screening for lung cancer with low-dose computed tomography (CT) in adults aged 55 to 80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years.2

"Less frequent screening would reduce radiation exposure but previous studies of longer screening intervals produced varied results," said lead author Mi-Young Kim, M.D., a radiologist at Asan Medical Center, Seoul, Korea. "This may have been caused by differences in the clinical and radiological presentation of lung cancer in women and men."

This study investigated sex differences in newly developed lung cancer and calculated the optimal CT screening intervals for women and men. The study retrospectively included 46,766 patients who underwent chest CT screening at Asan Medical Center between January 2000 and February 2016. During the study period, 282 patients developed lung cancer. Of these, 186 patients were diagnosed from the initial CT scan and were excluded from the study, while 96 patients (85 men, 11 women) were diagnosed from subsequent CT scans and were included in the study.

In the 96 patients, the researchers analyzed the CT screening intervals and the stage and pathology of lung cancer when it was diagnosed, to see if there were any sex differences.

The average time between lung cancer being diagnosed on CT and the previous CT scan was significantly longer in women (5.6 years) than in men (3.6 years). However, the lung cancer stage at diagnosis was higher in men: Eighty-two percent of lung cancers diagnosed in women were stage I compared to just 49 percent in men.

Pathological analyses showed that solid nodule (72 percent) was the most common finding in men, while ground glass opacity nodule (45 percent) was the most common in women. In men, adenocarcinoma was the most common type (42 percent), followed by squamous cell carcinoma (35 percent), small cell lung cancer (18 percent) and others (5 percent). All women patients had adenocarcinoma.

Kim said, "Because ground glass opacity nodule is the most common feature of lung cancer in women and all cases are adenocarcinoma, the growth rate of cancers might be low. Most female patients were non-smokers (82 percent), who have a lower risk of lung cancer, while 87 percent of men were smokers. We included all patients screened for lung cancer in a 17-year period, but the number of women patients was low and further studies are needed to confirm the sex differences we found."

She concluded, "Our study suggests that the annual follow-up interval for CT is too frequent for women, and scans every 2-3 years might be suitable. By reducing the number of unnecessary CT scans, we can decrease radiation exposure and increase cost effectiveness."

Commenting on the significance of the research, Pilar Garrido, M.D., head of the Thoracic Tumour Section of the Medical Oncology Department at Ramón y Cajal University Hospital, Madrid, Spain, said: "Lung cancer is the most common cancer globally, but debate about the optimal screening strategy is ongoing and current selection criteria are based only on age and pack-years. Several studies have highlighted that lung cancer has different features in women compared with men, thereby defining a different entity in female patients."

"Cancer incidence is expected to increase in the future, further straining limited healthcare resources," continued Garrido. "Personalized screening strategies, such as a gender approach, could be a way to optimize results and allocate resources appropriately."

She concluded, "The benefits, harms and feasibility of implementing gender-based lung cancer screening policies should be assessed and compared with those of current recommendations. The rate of non-smoking lung cancer is different between men and women and varies among countries. This should be taken into account when considering a gender-based lung cancer screening policy."

For more information: www.esmo.org

References

1. Abstract 18PD - 'Optimal screening interval for detection of newly developed lung cancer: Comparison of sexual difference' will be presented by Dr Hyun Jung Koo during the Poster Discussion session 'Epidemiology and innovations in biomarker development' on Saturday, 6 May, 16:45 (CEST).

2. https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummar...

Related Content

Machine Learning IDs Markers to Help Predict Alzheimer's

Neurologists use structural and diffusion magnetic resonance imaging (MRI) to identify changes in brain tissue (both gray and white matter) that are characteristic of Alzheimer's disease and other forms of dementia. The MRI images are analyzed using morphometry and tractography techniques, which detect changes in the shape and dimensions of the brain and in the tissue microstructure, respectively. In this example, the images show the normal brain of an elderly patient. Image courtesy of Jiook Cha.

News | Neuro Imaging | September 20, 2018
New research has shown a combination of two different modes of magnetic resonance imaging (MRI), computer-based...
SimonMed Deploys ClearRead CT Enterprise Wide
News | Computer-Aided Detection Software | September 17, 2018
September 17, 2018 — National outpatient physician radiology group SimonMed Imaging has selected Riverain Technologie
Siemens Healthineers Announces First U.S. Install of Somatom go.Top CT
News | Computed Tomography (CT) | September 17, 2018
September 17, 2018 — The Ohio State University Wexner Medical Center in Columbus recently became the first healthcare
Veye Chest version 2
News | Lung Cancer | September 11, 2018
Aidence, an Amsterdam-based medical AI company, announced that Veye Chest version 2, a class IIa medical device, has
The CT scanner might not come with protocols that are adequate for each hospital situation, so at Phoenix Children’s Hospital they designed their own protocols, said Dianna Bardo, M.D., director of body MR and co-director of the 3D Innovation Lab at Phoenix Children’s.

The CT scanner might not come with protocols that are adequate for each hospital situation, so at Phoenix Children’s Hospital they designed their own protocols, said Dianna Bardo, M.D., director of body MR and co-director of the 3D Innovation Lab at Phoenix Children’s.

Sponsored Content | Case Study | Radiation Dose Management | September 07, 2018
Radiation dose management is central to child patient safety. Medical imaging plays an increasing role in the accurate...
Carestream Releases Second-Generation Metal Artifact Reduction Software for OnSight 3D Extremity System
Technology | Computed Tomography (CT) | September 06, 2018
Carestream Health has started shipping a new software version for its Carestream OnSight 3D Extremity System that...

Image courtesy of Siemens Healthineers

Feature | CT Angiography (CTA) | September 06, 2018 | Dave Fornell
There have been a few big, recent advancements in cardiac computed tomography angiography (CCTA) imaging technology....
Key Patient Preparations for a CT Scan
News | Computed Tomography (CT) | September 05, 2018
The Center for Diagnostic Imaging (CDI) in Miami recently released a list of important preparations patients should...
PET Imaging Agent Predicts Brain Tau Pathology, Alzheimer's Diagnosis
News | PET Imaging | September 05, 2018
Eli Lilly and Co. and Avid Radiopharmaceuticals Inc. announced a Phase 3 study of positron emission tomography (PET)...
Check-Cap Announces Interim Results of European Study of C-Scan System Version 3
News | Colonoscopy Systems | September 04, 2018
Check-Cap Ltd. announced the interim results for its post-CE approval study of the C-Scan system Version 3, an...