News | Magnetic Resonance Imaging (MRI) | February 17, 2021

New study shows there is a lot to consider

T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.

T1 structural images for the two sequences, MPRAGE and MPRAGE+PMC. The top row shows the MPRAGE sequence, while the bottom row shows the images that were generated with the MPRAGE+PMC sequence. Columns represent two different participants, one with minimal head motion (left, Low-Mover) and another with a large quantity of motion (right, High-Mover). Pial and white matter (WM) surface reconstruction from Freesurfer are also shown.


February 17, 2021 — A new paper, "Is it time to switch your T1W sequence? Assessing the impact of prospective motion correction on the reliability and quality of structural imaging," evaluates two different ways of collecting magnetic resonance imaging (MRI) structural images. The first type of sequence, called MPRAGE, has been widely used by the neuroimaging research community for the last 20-plus years. More recently, an updated version of this sequence that includes Prospective Motion Correction (PMC) has been developed. The sequence with PMC adapts the MPRAGE sequence based on participant head motion. That makes it ideal for collecting data on children, who often struggle to hold still during MRIs. However, researchers are reluctant to change MRI sequences, since that typically means that they will not be able to use old and new data together in a statistical analysis.

"That's where this study comes in," said Alexandre Franco, Computational Neuroimaging Laboratories Director at The Nathan S. Kline Institute for Psychiatric Research and a research scientist at the Child Mind Institute. "It directly compares the reliability of the two sequences, MPRAGE and MPRAGE+PMC."

By using data collected for a Healthy Brain Network initiative that performed two MPRAGE and two MPRAGE+PMC sequences within the same imaging session, with one MPRAGE (MPRAGE1) and MPRAGE+PMC (MPRAGE+PMC1) pair at the beginning of the session and another pair (MPRAGE2 and MPRAGE+PMC2) at the end of the session, the new study directly compares two sequences from 348 participants. The study aimed to determine if the morphometric measurements obtained from both protocols are equivalent or if one sequence has a clear advantage over the other, while also comparing them through other quality control measurements. Results show that there is a high inter-sequence reliability between the MPRAGE and MPRAGE+PMC sequences. Results also indicate that the MPRAGE+PMC sequence is robust, but not impervious, to high head motion. "In the end use we suggest that studies targeting hyperkinetic populations use the MPRAGE+PMC sequence, given its higher robustness to head motion and higher reliability scores," said Franco.

For more information: www.childmind.org


Related Content

News | Cardiac Imaging

May 17, 2024 — The Cum Laude Award-Winning Online Poster presented during the 124th ARRS Annual Meeting found that the ...

Time May 17, 2024
arrow
News | Radiology Business

May 14, 2024 — University Hospitals (UH) and Siemens Healthineers announce a 10-year strategic alliance that builds on ...

Time May 14, 2024
arrow
News | Prostate Cancer

May 13, 2024 — Avenda Health, an AI healthcare company creating the future of personalized prostate cancer care, unveils ...

Time May 13, 2024
arrow
News | Radiology Imaging

May 13, 2024 — National Basketball Association (NBA), the National Basketball Players Association (NBPA), and the Next ...

Time May 13, 2024
arrow
News | Contrast Media

May 8, 2024 — Swedish biotech company Ascelia Pharma AB has announced that its liver imaging drug candidate, Orviglance ...

Time May 08, 2024
arrow
News | RSNA

May 7, 2024 — The Radiological Society of North America (RSNA) and the Radiological and Diagnostic Imaging Society of ...

Time May 07, 2024
arrow
News | Magnetic Resonance Imaging (MRI)

May 7, 2024 — The Magna Cum Laude Award-Winning Online Poster presented during the 124th ARRS Annual Meeting showed a ...

Time May 07, 2024
arrow
News | ARRS

May 7, 2024 — The American Roentgen Ray Society (ARRS) announced that Philip Costello, MD, the 118th ARRS President and ...

Time May 07, 2024
arrow
News | Treatment Planning

May 6, 2024 — Elekta announced the acquisition of Philips Healthcare’s Pinnacle Treatment Planning System (TPS) patent ...

Time May 06, 2024
arrow
News | Magnetic Resonance Imaging (MRI)

May 6, 2024 — Hvidovre Hospital has the world's first prototype of a sensor capable of detecting errors in MRI scans ...

Time May 06, 2024
arrow
Subscribe Now