Feature | Coronavirus (COVID-19) | July 06, 2020 | Dave Fornell, Editor

How COVID-19 Affects the Brain in Neuroimaging

Acute ischemic stroke, intracranial hemorrhage and several other abnormalities found in coronavirus patients from radiology brain imaging studies  

This is Figure 2 from the article in Radiology: Acute encephalopathy. A 60 year-old-man without history of seizures presenting with convulsion. (A-B) Multifocal areas of FLAIR hyperintensity in the right cerebellum (arrows in A), left anterior cingular cortex and superior frontal gyrus (arrows in B). (C-D) Restricted diffusion in the left anterior cingulate cortex, superior frontal and middle temporal gyrus (arrows in D) and right cerebellum (arrows in E), consistent with cerebellar diaschisis. F)  #COVID19

This is Figure 2 from the article in Radiology: Acute encephalopathy. A 60 year-old-man without history of seizures presenting with convulsion. (A-B) Multifocal areas of FLAIR hyperintensity in the right cerebellum (arrows in A), left anterior cingular cortex and superior frontal gyrus (arrows in B). (C-D) Restricted diffusion in the left anterior cingulate cortex, superior frontal and middle temporal gyrus (arrows in D) and right cerebellum (arrows in E), consistent with cerebellar diaschisis. F) No hemosiderin deposits in gradient echo sequences.

Four recent radiology studies, from New York, Italy, Iran and China, show how COVID-19 (SARS-CoV-2) impacts the brain of some infected patients. Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome which could be a trigger for ischemic strokes. Other abnormalities have also been found in COVID-19 patient brain imaging studies.

COVID-19 was originally thought to resemble the flu, with pneumonia lung manifests. However, it has become clear the past couple months that the virus also attacks the brain, heart, kidneys, vascular system, caused severe inflammatory responses, causes venous thromboembolism (VTE) and can cause multi-organ failure. Within the brain, COVID-19 patients have been observed with ischemic stroke, intracranial hemorrhage, focal cerebral arteriopathy, hypoxic-ischemic encephalopathy, encephalitis and acute hemorrhagic necrotizing encephalopathy.

“Currently, we have a poor mechanistic understanding of the neurological symptoms in COVID-19 patients, whether these are arising from critical illness or from direct central nervous system invasion of SARS-CoV-2,” wrote the authors of the first study, "Imaging in Neurological Disease of Hospitalized COVID-19 Patients: An Italian Multicenter Retrospective Observational Study," which was published as a research letter in the journal Radiology.[1] 

The study sought to systematically characterize neurological symptoms and neuroimaging features in hospitalized COVID-19 patients from multiple institutions in Italy. That country was the second epicenter of the spread of the disease when it left China in February, and at the time of study writing, Italy had 222,104 confirmed COVID-19 cases and 31,106 deaths. Several studies have described the spectrum of chest imaging features of COVID-19,[2] However, to date, only a few case reports have described COVID-19 associated neuroimaging findings.[3–8] This study tried to consolidate the neuro-imaging COVID-19 findings into one document.

Of 725 consecutive hospitalized patients with COVID-19, 108 (15%) had acute neurological symptoms requiring neuroimaging. It is the largest study to date of neuroimaging findings in patients with COVID-19 hospitalized in multiple institutions in Italy. The most common neurological symptoms were altered mental status in 64 (59%) patients and ischemic stroke in 34 (31%) patients. Find a complete list of characteristics for the COVID-19 patients in Figure 1 of this article.

Of the 108 patients with ischemic stroke, 31 (29%) had no known past medical history and 77 (71%) had at least one of the following chronic disorders: coronary artery disease 25 (23%), cerebrovascular disease 15 (14%), hypertension 55 (51%) and diabetes 30 (28%). Of the 31 (29%) patients with no known past medical history (age range 16-62 years), 10 had acute ischemic infarcts and 2 had intracranial hemorrhage.

All imaging was obtained using magnetic resonance imaging (MRI) brain and spine scans, performed on 1.5T scanners with standardized protocols. For contrast studies, Gd-DTPA (0.1 mmol/kg gadobutrol [Gadovist]) was used.

Scans showed 47% of patients (51 out of 108) had acute neuroimaging abnormalities. These included:
   • 34 (31% with acute ischemic infarcts
   • 6 (6%) intracranial hemorrhage
   • 2 (12%) cerebral venous thrombosis
   • 2 (10%) multiple sclerosis (MS) plaque exacerbation
   • 2 (10%) nonspecific encephalopathy
   • 2 (10%) Guillian-Barre syndrome (rare disorder in which the body's immune system attacks the nerves)
   • 1 (10%) Miller-Fisher syndrome (rare, acquired nerve disease with abnormal muscle coordination, paralysis of the eye muscles and absence of the tendon reflexes. Usually preceded by a viral illness.)
   • 1 (5%) posterior reversible encephalopathy syndrome (PRES). Characterized by a headache, seizures, altered mental status and visual loss, and by white matter vasogenic edema.
   • 1 (5%) acute encephalopathy

"Our study demonstrated that the neuroimaging features of hospitalized COVID-19 patients were variable, without specific pattern, but dominated by acute ischemic infarcts and intracranial hemorrhages. We also showed that MR neuroimaging spectrum may include posterior reversible encephalopathy syndrome (PRES), hypoxic-ischemic encephalopathy, exacerbation of demyelinating disease and nonspecific cortical pattern of T2 FLAIR hyperintense signal with associated restriction diffusion that may be caused by systemic toxemia, viremia and/or hypoxic effects," the authors concluded. 

The authors also noted a lower prevalence of central nervous system (CNS) symptoms than the Wuhan, China, experience [8] (15 vs. 25%). However the prevalence of ischemic strokes was higher in the Italian study (31 vs. 11%). 

 

COVID-19 Can Cause Diffuse Disorders of White Matter and Micro-hemorrhages

Diffuse leukoencephalopathy and juxtacortical/callosal microhemorrhages were brain imaging features in critically ill COVID-19 patients found in a study from the New York University School of Medicine.[9] The study reported brain imaging features in 11 critically ill COVID-19 patients with persistently depressed mental status who underwent MRI between April 5-25, 2020. 

These features included:
   • Confluent T2 hyperintensity and mild restricted diffusion in bilateral supratentorial deep and subcortical white matter (in 10 of 11 patients).
   • Multiple punctate microhemorrhages in juxtacortical and callosal white matter (in 7 of 11 patients).

Figure 1. Brain MRI in two critically ill COVID-19 patients with persistently depressed mental status including a 56-year old man (A-C), and a 64-year old man (D-F). Axial diffusion-weighted (A, D), apparent diffusion coefficient (B, E), and FLAIR (C, F) images at the level of centrum semiovale in both patients demonstrate symmetric diffuse T2/FLAIR hyperintensity (arrowheads) and mild restricted diffusion (thick arrows) involving the deep and subcortical white matter with relative sparing of juxtacortical white matter (thin arrows) in both patients. The restricted diffusion is more conspicuous than the T2/FLAIR hyperintensity.  https://pubs.rsna.org/doi/10.1148/radiol.2020202040

Figure 1 from the Radiology article. Brain MRI in two critically ill COVID-19 patients with persistently depressed mental status including a 56-year old man (A-C), and a 64-year old man (D-F). Axial diffusion-weighted (A, D), apparent diffusion coefficient (B, E) and FLAIR (C, F) images at the level of centrum semiovale in both patients demonstrate symmetric diffuse T2/FLAIR hyperintensity (arrowheads) and mild restricted diffusion (thick arrows) involving the deep and subcortical white matter with relative sparing of juxtacortical white matter (thin arrows) in both patients. The restricted diffusion is more conspicuous than the T2/FLAIR hyperintensity.

 

Researchers said abnormalities extended from the precentral gyrus down to the centrum semiovale and corona radiata. At the level of temporal and occipital horns, the posterior cerebral white matter in all patients was involved more than the anterior. The deep gray nuclei were spared. The juxtacortical white matter was also relatively spared, with the exception of the pre-central gyrus in all 10 patients and occipital lobes in seven patients. One patient received intravenous contrast for the MRI and there was no abnormal intracranial enhancement.

The infratentorial parenchyma tended to be less affected, seen only in four patients with mild involvement of middle cerebellar peduncles and medial cerebellar hemispheres.

The study includes numerous images showing these findings.

COVID-19 Pediatric Patient With Focal Cerebral Arteriopathy

In research published in Radiology on June 2, researchers in Iran and Children’s Hospital of Philadelphia presented a case of focal cerebral arteriopathy (FCA) and ischemic stroke in a pediatric COVID-19 patient who presented with seizure, right hemiparesis (weakness), and dysarthria (difficulty speaking) and who tested positive for SARS-CoV2 virus both from nasopharyngeal swab and cerebral spinal fluid.[10] FCA is a common cause of ischemic stroke in previously healthy children.

The researchers said the neuroinvasive mechanism of SARS-CoV-2 is not fully understood. It may enter the CNS through the blood, with other proposed routes, including the olfactory and trigeminal nerves, cerebral spinal fluid (CSF) and the lymphatic system.[11] Neurologic manifestations in COVID-19 pediatric patients are not common, but are reported, and this is this one such presumptive case of ischemic stroke due to FCA associated with COVID-19.

The case involves a previously healthy 12-year-old-boy with new onset of generalized seizures, initially treated with Diazepam. Shortly after, he developed right-sided hemiparesis and dysarthria. There was no previous history of fever, cough, shortness of breath, skin rash, hemoglobinopathy or recent trauma. No one in his family had a known history of COVID-19 infection.

Figure 1: Axial T2-weighted (a) and FLAIR (b) Magnetic resonance imaging show diffuse hyperintense signal and edema of the caudate nucleus head, putamen, anterior limb of the internal capsule, and parts of external capsule and insula on the left side, with corresponding low values on the axial apparent diffusion coefficient map, in keeping with an acute infarct. Time-of-flight magnetic resonance angiography maximal intensity projection reformatted image demonstrates focal irregular narrowing and banding of the proximal left M1 segment of the middle cerebral artery with a slightly reduced distal flow in the middle cerebral artery.

Figure 2 from the Radiology article: Axial T2-weighted (a) and FLAIR (b) Magnetic resonance imaging show diffuse hyperintense signal and edema of the caudate nucleus head, putamen, anterior limb of the internal capsule, and parts of external capsule and insula on the left side, with corresponding low values on the axial apparent diffusion coefficient map, in keeping with an acute infarct. Time-of-flight magnetic resonance angiography maximal intensity projection reformatted image demonstrates focal irregular narrowing and banding of the proximal left M1 segment of the middle cerebral artery with a slightly reduced distal flow in the middle cerebral artery.
 

There were no symptoms of other systems involvement, cervical enlarged lymph nodes, rash or redness. The patient had no respiratory abnormalities. The patient received conservative management. The patient is at home undergoing rehabilitation.

The researchers said the major imaging findings in this patient are the presence of unilateral focal vasculopathy, characterized by focal irregular narrowing and banding of the proximal left middle cerebral artery associated with left basal ganglia and insula acute infarct. There are many potential differential considerations in a child with acute stroke, including FCA, arterial dissection, embolic or thrombotic stroke, cerebral vasculitis in the context of systemic disease (including Kawasaki disease), and genetic disorders with arteriopathy, among others. Their leading diagnosis is FCA, which is defined by Wintermark et al.[13] Based on the patient’s history and lack of thrombotic processes outside the CNS, embolic stroke and dissection were considered less likely than FCA. 

There have been numerous reports of multi-system inflammatory syndrome in children (MIS-C), which causes an elevated immune response in COVID-19 pediatric patients that process Kawasaki disease-like presentations. There was no evidence to suggest a multi-system inflammatory syndrome or Kawasaki-like presentation, as the patient did not show any of the classical clinical physical findings, the researchers said. 

Read more in the article Kawasaki-like Inflammatory Disease Affects Children With COVID-19. 
 

Encephalitis as a Clinical Manifestation of COVID-19

Viral infections have detrimental impacts on neurological functions and can cause severe neurological damage. A study from China showed coronavirus can exhibit neurotropic properties and may also cause neurological diseases. Researchers looked at neurological complications in COVID infections and the possible mechanisms of damage to the nervous system.[13]  They found most neurological diseases could be caused by coronavirus invasion and COVID-19 causes nerve damage via diverse pathways.

On March 4, 2020, Beijing Ditan Hospital reported the first case of viral encephalitis caused by novel coronavirus attacking the central nervous system. The researchers confirmed the presence of SARS-CoV-2 in the cerebrospinal fluid by genome sequencing. It illustrated that COVID-19 has potential to cause nervous system damage.

A Wuhan male had fever, shortness of breath and myalgia since Jan 28. On Feb 10, his disease deteriorated and his consciousness suddenly progressed to confusion. Laboratory tests indicated low WBC count (3.3 x 109/L) and lymphopenia (0.8 x 109/L). Skull computed tomography (CT) was normal, while chest CT showed multiple subpleural ground glass opacities (GGOs). The patient was positive for SARS-CoV-2. On physical examination, vital signs were stable without altered consciousness. Meningeal irritation signs (including nuchal rigidity, Kernig sign and Brudzinski sign) and extensor plantar response were present. 

Fig. 1. The mechanisms of coronaviruses infections and neurological damage caused by coronaviruses. The coronaviruses can cause nerve damage through direct infection pathways (blood circulation pathways and neuronal pathways), hypoxia, immune injury, ACE2, and other mechanisms. Meanwhile, the coronaviruses have detrimental effects to attack the lung tissue, and causes a series of lung lesions such as hypoxia. Furthermore, the coronaviruses can enter the nervous system directly through the olfactory nerve, and also enter the nervous system through blood circulation and neuronal pathways, resulting in neurological disorders. Ab: antibody; ACE2: angiotensin-converting enzyme 2; CSF: cerebrospinal fluid; ER: endoplasmic reticulum; TNF: tumor necrosis factor.  https://www.sciencedirect.com/science/article/pii/S0889159120303573 #COVID19

Figure 1 from the journal Brain, Behavior, and Immunity. The mechanisms of coronaviruses infections and neurological damage caused by coronaviruses. The coronaviruses can cause nerve damage through direct infection pathways (blood circulation pathways and neuronal pathways), hypoxia, immune injury, ACE2 and other mechanisms. Meanwhile, the coronaviruses have detrimental effects to attack the lung tissue, and causes a series of lung lesions such as hypoxia. Furthermore, the coronaviruses can enter the nervous system directly through the olfactory nerve, and also enter the nervous system through blood circulation and neuronal pathways, resulting in neurological disorders. Ab: antibody; ACE2: angiotensin-converting enzyme 2; CSF: cerebrospinal fluid; ER: endoplasmic reticulum; TNF: tumor necrosis factor.

 

The study said arterial blood gas analysis indicted PO2/FiO2 ratio of 240 mmHg. This COVID-19 patient was treated with arbidol and oxygen therapy, whereas his consciousness was not improved. Lumbar puncture was performed on Feb. 16, and the cerebrospinal fluid (CSF) pressure was 220 mmHg. Laboratory tests with CSF showed WBC (0.001 x 109/L), protein (0.27 g/L), ADA (0.17 U/L) and sugar (3.14 mmol/L) contents within normal limits. The CSF specimen was further tested for SARS-CoV-2 but the result was negative. 

This patient did not have evidence of bacterial or tuberculous infection of the CNS. After careful evaluation by neurologic experts, encephalitis associated with COVID-19 infection was concluded. 

Treatment was largely supportive, including mannitol infusion. The patient’s consciousness was generally unsatisfactory since Feb. 20, and chest CT suggested a resolution of GGOs. The patient regained clear consciousness Feb. 24. Two consecutive throat swab tests were negative for SARS-CoV-2. The patient was discharged from hospital Feb. 27.

All RSNA COVID-19 research articles can be found at Special Focus: COVID-19. Additional COVID-19 resources can be found at RSNA.org/COVID-19.

See more medical imaging of COVID-19 in the photo gallery How COVID-19 Appears on Medical Imaging.

 

References:

1. Abdelkader Mahammedi, Luca Saba, Achala Vagal, et al. Imaging in Neurological Disease of Hospitalized COVID-19 Patients: An Italian Multicenter Retrospective Observational Study. Radiology. Published online May 21, 2020. https://doi.org/10.1148/radiol.2020201933.

2. Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020 Feb 4;295(1):202–7. 

3. Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L et al. Acute Cerebrovascular Disease Following COVID-19: A Single Center, Retrospective, Observational Study. SSRN Electronic Journal 2020;10.2139/ssrn.3550025.

4. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. Radiology. 2020 Mar 31;201187. 

5. Filatov A, Sharma P, Hindi F, Espinosa PS. Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy. Cureus. 2020 Mar; 12(3): e7352. 

6. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med. 2020 Apr 15. doi: 10.1056/NEJMc2008597.

7. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International Journal of Infectious Diseases. 2020 May 1;94:55–8. 

8. Mao L, Wang M, Chen S, He Q, Chang J, Hong C et al. Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study. JAMA Neurol. Published online April 10, 2020. doi:9.1001/jamaneurol.2020.1127. 

9. Alireza Radmanesh, Anna Derman, Yvonne W. Lui, et al. COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages. Radiology. Published online May 21, 2020. https://doi.org/10.1148/radiol.2020202040.

10. Seyed Mohammad Mousavi Mirzaee, Fabrício Guimaraes Goncalves, Mahyar Mohammadifard, et al. Focal Cerebral Arteriopathy in a COVID-19 Pediatric Patient. Radiology. Published online June 2, 2020. https://doi.org/10.1148/radiol.2020202197.

11. Li Z, Liu T, Yang N, Han D, Mi X, Li Y et al. Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain. Front. Med. 2020 May 4;  DOI: 10.1007/s11684-020-0786-5.

12. Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR et al. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017 Nov;38(11):2172–9. 

13. Yeshun Wu, Xiaolin Xu, Zijun Chen, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, Behavior, and Immunity. Published online March 30, 2020. https://doi.org/10.1016/j.bbi.2020.03.031.

 

Related Content

If you plan to attend HIMSS21 Aug. 9-13 in Las Vegas, be sure to note that due to health and safety updates, masks will now be required for attendees and exhibitors.

Getty Images

News | HIMSS | July 28, 2021
July 28, 2021 —If you plan to attend HIMSS21 Aug.
The global medical imaging and informatics market is experiencing dynamic changes with the emergence of advanced technologies, evolving clinical and administrative needs, and the introduction of new policies and regulations, which is forcing industry participants to innovate to maintain their competitive edge

Getty Images

News | Coronavirus (COVID-19) | July 26, 2021
July 26, 2021 — The global medical imaging and informatics market is experiencing dynamic changes with the emergence
Registration is now open for the Radiological Society of North America (RSNA) 107th Scientific Assembly and Annual Meeting, the world’s largest annual radiology forum, to be held at McCormick Place Chicago, Nov. 28 – Dec. 2, 2021

Getty Images

News | RSNA | July 21, 2021
July 21, 2021 — Registration is now open for the Radiological Society of North America (...
ASTRO just issued the following statement in response to the Radiation Oncology Model update in yesterday's HOPPS proposed rule, which compounds significant and detrimental cuts to the cancer care specialty in the proposed 2022 MPFS

Getty Images

News | Radiation Therapy | July 20, 2021
July 20, 2021 — In response to consecutive weeks of proposed...
ujifilm's robust medical systems portfolio includes a comprehensive product lineup covering CT, MRI, fluoroscopy, digital radiography, women’s health, ultrasound, systems integration, endoscopy and endosurgery, enterprise imaging, assisted reproductive technology, cell culture media, cell therapy development, In-Vitro diagnostics (IVD), and investigational drug development
News | Radiology Imaging | July 14, 2021
July 14, 2021 — Fujifilm announced the launch of the ...
More complex, longer interventional procedures such as structural heart interventions or this revascularization of a coronary chronic total occlusion (CTO) at Henry Ford Hospital in Detroit, requires angiography imaging systems that have improved image detail and lower radiation dose. However, purchase of new systems was put on hold by many hospitals in 2020 due to the sudden drop in elective procedures and diversion of resources due to the COVID-19. Photo by Dave Fornell.

More complex, longer interventional procedures such as structural heart interventions or this revascularization of a coronary chronic total occlusion (CTO) at Henry Ford Hospital in Detroit, requires angiography imaging systems that have improved image detail and lower radiation dose. However, purchase of new systems was put on hold by many hospitals in 2020 due to the sudden drop in elective procedures and diversion of resources due to the COVID-19. Photo by Dave Fornell.

Feature | Mobile C-Arms | July 07, 2021 | By Bhvita Jani
With the postponement of non-essential elective surgeries and medical procedures in 2020 to conserve medical resource
The demands on radiologists have become more complex which has led to the need to have greater control over how technology supports the goals and objectives of the organization

Getty Images

Feature | Information Technology | July 06, 2021 | By Jef Williams