News | Coronavirus (COVID-19) | November 20, 2023

For the study, 54 patients were treated with a stellate ganglion block, which includes injecting anesthetic directly into the nerves on one side of the neck to stimulate the nervous system

 CT-guided stellate ganglion injection. (Courtesy of Radiology)

November 20, 2023 — Using an image-guided minimally invasive procedure, researchers may be able to restore the sense of smell in patients who have suffered with long-COVID, according to research being presented next week at the annual meeting of the Radiological Society of North America (RSNA).

Parosmia, a condition where the sense of smell no longer works correctly, is a known symptom of COVID-19. Recent research has found that up to 60% of COVID-19 patients have been affected. While most patients do recover their sense of smell over time, some patients with long COVID continue to have these symptoms for months, or even years, after infection, negatively impacting their appetite for food and their overall quality of life.

"Post-COVID parosmia is common and increasingly recognized," said the study's lead author, Adam C. Zoga, M.D., M.B.A., professor of musculoskeletal radiology at Jefferson Health in Philadelphia, Pennsylvania. "Patients can develop a distaste for foods and drinks they used to enjoy."

The distorted sense of smell can also affect smell perception, and some patients may suffer from phantosmia, a condition that causes people to detect smells—foul or pleasant—that aren't in their environment.

To assess a possible treatment for patients with long-term post-COVID parosmia, researchers looked at the potential benefits of CT-guided stellate ganglion block. Part of the autonomic nervous system, which regulates involuntary processes including heart rate, blood pressure, breathing and digestion, the stellate ganglia are nerves on each side of the neck. They deliver certain signals to the head, neck, arms and a portion of the upper chest.

The research team used a stellate ganglion block, which includes injecting anesthetic directly into the stellate ganglion on one side of the neck to stimulate the regional autonomic nervous system. The minimally invasive procedure takes less than 10 minutes, and no sedation or intravenous analgesia is necessary. Stellate ganglion block has been used with varying degrees of success to treat a number of conditions, including cluster headaches, phantom limb pain, Raynaud's and Meniere's syndromes, angina and cardiac arrhythmia.

Adam C. Zoga, M.D., M.B.A.

Adam C. Zoga, M.D., M.B.A.

"Parosmia has previously been reported as a rare disorder occurring after brain trauma, brain surgery, stroke, viral syndromes, and with some head and neck tumors," Dr. Zoga said. "We were not entirely confident that the procedure would work for parosmia."

For the study, 54 patients were referred from an ear, nose and throat specialist after at least six months of post-COVID parosmia that was resistant to pharmaceutical and topical therapies.

CT guidance was used to position a spinal needle at the base of the neck for injection into the stellate ganglion. The researchers added a small dose of corticosteroid to the anesthetic in the pharmacologic preparation, suspecting that the COVID virus may be causing nerve inflammation.

"The initial patient had a tremendously positive outcome, almost immediately, with continued improvement to the point of symptom resolution at four weeks," Dr. Zoga said. "We have been surprised at some outcomes, including near 100% resolution of phantosmia in some patients, throughout the trial."

Follow-up was obtained for 37 patients (65%), with 22 (59%) of the 37 reporting improved symptoms at one week post-injection. Of these 22, 18 (82%) reported significant progressive improvement by one month post-procedure. At three months, there was a mean 49% improvement in symptoms (range 10% to 100%) among the 22 patients.

Twenty-six patients returned for a second injection given on the other side (contralateral) of their neck after at least a six-week interval. While the second injection was not effective in patients who did not respond to the first injection, 86% of patients who reported some improvement after the first injection reported additional improvement after the contralateral injection. No complications or adverse events were reported.

"Other treatments have failed to date," Dr. Zoga said. "This injection is working."

Co-authors are Sarah I. Kamel, M.D., T. Rohan, M. A. Moriarty, Johannes B. Roedl, Ph.D., M.D., Vishal Desai, M.D., and Jeffrey A. Belair, M.D.

For more information: www.rsna.org

Find more RSNA23 conference coverage here

 

Related content: 

MRI Reveals Significant Brain Abnormalities Post-COVID 

MRI Innovation Makes Cancerous Tissue Light Up and Easier to See 

Long COVID Syndrome in Children and Teens 

Long COVID Implications: Increased Health Care Use After Infection With SARS-Cov-2 

Lasting Lung Damage Seen in Children and Teens after COVID  

PHOTO GALLERY: How COVID-19 Appears on Medical Imaging   

COVID-19 Fallout May Lead to More Cancer Deaths    

Kawasaki-like Inflammatory Disease Affects Children With COVID-19    

FDA Adds Myocarditis Warning to COVID mRNA Vaccine Clinician Fact Sheets    

CMS Now Requires COVID-19 Vaccinations for Healthcare Workers by January 4    

Cardiac MRI of Myocarditis After COVID-19 Vaccination in Adolescents    

Small Number of Patients Have Myocarditis-like Illness After COVID-19 Vaccination    

Overview of Myocarditis Cases Caused by the COVID-19 Vaccine    

Case Study Describes One of the First U.S. Cases of MIS-C    

NIH-funded Project Wants to Identify Children at Risk for MIS-C From COVID-19 


Related Content

News | Mammography

April 12, 2024 — Bayer and Hologic, Inc. announced a first-of-its-kind collaboration to deliver a coordinated solution ...

Time April 12, 2024
arrow
News | Mammography

April 12, 2024 — GE HealthCare, a leader in breast health technology and diagnostics, will feature its latest breast ...

Time April 12, 2024
arrow
News | Ultrasound Imaging

April 9, 2024 — A new Society of Radiologists in Ultrasound (SRU) expert consensus statement to improve endometriosis ...

Time April 09, 2024
arrow
News | Population Health

April 4, 2024 — A new study found increased coronary vessel wall thickness that was significantly associated with ...

Time April 04, 2024
arrow
News | Radiation Oncology

April 2, 2024 — In a 10-center study, microwave ablation offered progression free survival rates and fewer complications ...

Time April 02, 2024
arrow
News | Mammography

April 1, 2024 — Researchers have developed a new, interpretable artificial intelligence (AI) model to predict 5-year ...

Time April 01, 2024
arrow
News | Radiation Therapy

March 28, 2024 — RefleXion Medical, Inc., a therapeutic oncology company, and Limbus AI, Inc., a provider of software ...

Time March 28, 2024
arrow
Feature | Ultrasound Imaging | By Christine Book

The global ultrasound devices market size was estimated at $9.79 billion in 2023 and is anticipated to expand at a ...

Time March 20, 2024
arrow
News | Artificial Intelligence

March 18, 2024 — RamSoft, a global leader in novel cloud-based RIS/PACS radiology solutions for imaging centers and ...

Time March 18, 2024
arrow
News | Breast Imaging

March 18, 2024 — QT Imaging Holdings, Inc., a medical device company engaged in research, development, and ...

Time March 18, 2024
arrow
Subscribe Now