Ultrasound-guided biopsies miss prostate cancers that are detected by the slightly more expensive and slightly more invasive 3-D mapping biopsies. A 2006 study compared ultrasound-guided biopsy of 180 men diagnosed with early stage prostate cancer to 3-D mapping biopsy. The study showed nearly a quarter of patients were upgraded to a more clinically significant stage of disease after 3-D mapping found pockets of cancer missed by the first technique. A University of Colorado Cancer Center study reports the locations of these most-missed pockets of prostate cancer.
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