News | Radiopharmaceuticals and Tracers | August 16, 2017

Study Demonstrates First Human Application of Novel PET Tracer for Prostate Cancer

New tracer holds promise of monitoring targeted treatment of various cancers

Study Demonstrates First Human Application of Novel PET Tracer for Prostate Cancer

Transaxial 11Csarcosine hybrid PET/CT showed a (triangulated) adenocarcinoma in the transition zone of the anterior right prostate gland on PET (A), CT (B), and a separately obtained T2?weighted MR sequence (C) with resulting PET/MRI registration (D). Image courtesy of M. Piert et al., University of Michigan, Ann Arbor, Mich.

August 16, 2017 — In the featured translational article in the August issue of The Journal of Nuclear Medicine, researchers at the University of Michigan demonstrate the potential of a new positron emission tomography (PET) tracer, Carbon-11 labeled sarcosine (11C-sarcosine), for imaging prostate cancer. The article also sets the stage for its possible use in monitoring other cancers.

The study compared the effectiveness of the new tracer with 11C-choline (already widely used for imaging prostate cancer) in two mouse models and also performed the first PET/CT (computed tomography) scan with 11C-sarcosine of a human with prostate cancer.

According to the Centers for Disease Control and Prevention (CDC), prostate cancer is the second most deadly cancer among men. Sarcosine plays an important role in its aggressiveness and progression. Sarcosine enters cells via proton-coupled amino acid transporters (PAT), which are overexpressed in selected tissues and solid tumors — making it an excellent imaging target.

"Given the link between 11C-sarcosine cell uptake and PAT transport, the study provides first evidence that PAT expression can be elevated in prostate cancer," explained Morand Piert, M.D., professor of radiology, Division of Nuclear Medicine at the University of Michigan.

Study results showed that in preclinical models tumor-to-background ratios obtained from 11C-sarcosine PET were significantly elevated compared to 11C-choline. 11C-sarcosine also produced high-contrast images in a human prostate cancer case. Independent target metabolite analyses revealed significant increases of sarcosine, glycine and choline tissue levels from benign prostate tissue to localized prostate cancer and subsequently metastatic disease. The data suggest that 11C-sarcosine is a viable tracer for prostate cancer imaging, with potential benefits over 11C-choline.

Piert noted that 11C-sarcosine could also be an important tracer for identifying and characterizing other cancers. He explained, "To our knowledge, this is the first radiotracer to interrogate the activity of PATs, which play a role as multi-purpose carriers with distinct roles in different cells. In the brain, these transporters are involved in the neuronal amino acid transport. In the intestinal tract, certain PATs play a role as nutrient and drug transporter."

Piert added, "Furthermore, PAT expression increases with cell proliferation. In cancer, PAT function has been related to the amino acid-sensing engine that drives activation of the mammalian target of rapamycin complex 1 (mTORC1), which is an important target for existing and new anti-cancer drugs."

While further studies are needed for clinical validation, he said, "Based on the known metabolism of sarcosine in cancer, we postulate that elevated 11C-sarcosine uptake is a negative prognostic marker and may potentially be useful to monitor mTORC1-targeted cancer treatments."

For more information: www.jnm.snmjournals.org

Related Content

Micro-Ultrasound and Artificial Intelligence Combining to Detect Prostate Cancer
News | Prostate Cancer | February 12, 2019
Cambridge Consultants has partnered with Exact Imaging, makers of the ExactVu micro-ultrasound platform, as the two...
ImaginAb Enrolls First Patient in Phase II PET Agent Clinical Trial
News | Radiopharmaceuticals and Tracers | January 30, 2019
ImaginAb Inc. announced the enrollment of the first patient in the Phase II clinical trial of the company’s CD8+ T Cell...
Southern Asia's First Proton Therapy Center Begins Treatments
News | Proton Therapy | January 28, 2019
IBA (Ion Beam Applications SA) announced the opening of the Apollo Proton Cancer Centre in Chennai, India, and the...
FDA Clears United Imaging Healthcare uExplorer Total-Body Scanner
Technology | PET-CT | January 23, 2019
January 23, 2019 — United Imaging Healthcare (United Imaging) announced U.S.
MIM Software Inc. Receives FDA 510(k) Clearance for Molecular Radiotherapy Dosimetry
Technology | Nuclear Imaging | January 16, 2019
MIM Software Inc. received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for molecular radiotherapy...
Brachytherapy Alone Superior Treatment for Intermediate-Risk Prostate Cancer
News | Brachytherapy Systems | January 04, 2019
Patient-reported outcomes (PROs) indicated a significantly different clinician and patient-reported late toxicity...
Videos | SPECT-CT | December 12, 2018
This is a walk around of the new Spectrum Dynamics Veriton SPECT-CT nuclear imaging system introduced at the 2018 ...
Spectrum Dynamics Sues GE for Theft, Misappropriation of Trade Secrets and Unfair Competition
News | SPECT Imaging | December 06, 2018
Single-photon emission computed tomography (SPECT) cardiac imaging company Spectrum Dynamics filed a lawsuit Dec. 6,...
Subtle Medical Receives FDA Clearance, CE Mark for SubtlePET
Technology | PET Imaging | December 05, 2018
Subtle Medical announced 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market SubtlePET. Subtle...
Mirada Medical Joins U.K. Consortium Exploring Healthcare AI
News | Artificial Intelligence | December 04, 2018
Mirada Medical, a leading global brand in medical imaging software, will form part of an artificial intelligence (AI)...