News | July 29, 2007

Siemens Collaborates on Study of Imaging Biomarker to Detect Activity of Cancer Cells

July 30, 2007 – Siemens Medical Solutions announced today that it has been granted an Investigational New Drug (IND) Exemption by the U.S. Food and Drug Administration (FDA) to conduct a Phase I clinical trial of (F-18) 3'-fluoro-3'-deoxythymidine (FLT), a molecular imaging biomarker that has shown promise in monitoring the proliferation of cancer cells, which could help physicians quickly determine the effectiveness of cancer therapies.

To broaden the scope of FLT research, Siemens will support the FLT Phase I clinical trial that will be conducted at Memorial Sloan-Kettering Cancer Center located in New York City, with whom Siemens has signed a research collaboration agreement focused on the codevelopment of imaging biomarkers that will be used in PET imaging. Through these collaborative efforts, Siemens intends not only to make FLT more readily accessible to research and academic institutions for further study, but also to continue research into new more target specific imaging biomarkers for PET.

The significance of FLT is that it may be able to allow researchers and physicians to detect the rate of the proliferation of cancerous cells through a molecular imaging technique like PET-CT (positron emission tomography-computed tomography), by enabling visualization of key steps in the replication of DNA, which precedes cell division. By enabling the imaging of the biological processes within cancer cells, FLT could help physicians to personalize cancer therapies by more quickly assessing cancer therapies, avoiding ineffective therapies and determining the most appropriate treatment for an individual patient.

For more information: www.usa.siemens.com/medical

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