News | Colonoscopy Systems | August 06, 2019

Rise in Early Onset Colorectal Cancer Not Aligned With Screening Trends

Study adds to evidence other factors are driving increase

Rise in Early Onset Colorectal Cancer Not Aligned With Screening Trends

August 6, 2019 — A new study finds that trends in colonoscopy rates did not fully align with the increase in colorectal cancer (CRC) in younger adults, adding to evidence that the rise in early onset CRC is not solely a result of more detection. The study is published early online in the Journal of Medical Screening.

CRC incidence rates are declining rapidly in adults older than 55 years in the U.S., partly because of the widespread uptake of colonoscopy, which can remove precancerous growths, lowering incidence rates. In contrast, CRC incidence in younger adults is rising.

There remains debate whether the rise in incidence in younger adults reflects an actual increase in disease, or rather increased detection as a result of more colonoscopies being performed over time.

To add clarity to this debate, American Cancer Society researchers led by Stacey Fedewa, Ph.D. determined past-year colonoscopy rates among more than 50,000 respondents ages 40-54 in the National Health Interview Survey data. Colorectal cancer incidence rates and incidence rate ratios were calculated based on 18 population-based Surveillance Epidemiology and End Results (SEER) registries during the same period.

Between 2000 and 2015, past-year colonoscopy rates were fairly stable among people aged 40-44 (remaining under 3 percent), while colorectal cancer incidence rates increased by 28 percent. Among those ages 45-49, colonoscopy rates doubled (from 2.5 percent in 2000 to 5.2 percent in 2015), while colorectal cancer incidence rates increased by 15 percent. In those ages 50-54, colonoscopy rates increased by about 2.5 times (from 5 percent to 14.1 percent), while incidence rates rose 17 percent.

If the growing incidence of young onset CRCs were a result of more detection, larger increases in early-stage diagnoses would be anticipated because screening is most likely to detect localized disease. To investigate this, researchers examined stage-specific CRC incidence trends from 2000-2015. Increases for localized stage disease occurred in ages 40-44, among whom colonoscopy was stable, but not in ages 45-49, among whom colonoscopy had increased. However, distant stage disease increased in every age group, and was steeper (2.9 percent per year) than that for localized stage (1.1 percent per year) in ages 40-44 years.

"The changes in past-year colonoscopy rates did not fully align with the rise in overall and distant stage colorectal cancer incidence rates in all three age groups during the corresponding period," said Fedewa. "There were some concordant patterns, like the rise in both colonoscopy and early stage incidence among 50-54 years, but there were also some discordant patterns, such as the lack of increase in colonoscopy among people in their early 40's to match the increasing rates of CRC in this age group."

"Future studies should examine reasons for the rising CRC incidence rates in young adults," the study concludes.

For more information: www.journals.sagepub.com/home/msc

 

Reference

Fedewa S.A., Siegel R.L., Jemal A. Are temporal trends in colonoscopy among young adults concordant with colorectal cancer incidence?; J Med Screen, July 11, 2019. DOI: 10.1177/0969141319859608.

Related Content

Virtual reality during chemotherapy has been shown to improve breast cancer patients’ quality of life during the most stressful treatments
News | Virtual and Augmented Reality | January 21, 2020
January 21, 2020 — Virtual reality during chemotherapy has been shown to improve...
Researchers at Karolinska Institutet in Sweden and Tampere University in Finland have developed a method based on artificial intelligence (AI) for histopathological diagnosis and grading of prostate cancer

From left: Peter Ström, Martin Eklund, Kimmo Kartasalo, Henrik Olsson och Lars Egevad, researchers at Karolinska Institutet in Sweden. Photo courtesy of Stefan Zimmerman

News | Prostate Cancer | January 20, 2020
January 20, 2020 — Researchers at Karolinska Institutet in Sweden and...
Professor Samer Ezziddin, M.D., from Saarland University/Saarland University Hospital.

Professor Samer Ezziddin, M.D., from Saarland University/Saarland University Hospital. Image courtesy of Saarland University/Thorsten Mohr

 

News | Prostate Cancer | January 13, 2020
January 13, 2020 — When a non-scientist tries to imagine a scientist, the image that often arises is one of a somewha
The study found that DBN laws helped some women understand they had increased breast density, but not that breast density is associated with a higher risk of breast cancer or that dense breasts limit the ability of mammograms to detect cancer
News | Breast Density | January 09, 2020
January 9, 2020 — A new study suggests that state-mandated notifications on...
prostate cancer UCL study
News | Prostate Cancer | January 03, 2020
January 3, 2020 — Nearly one in six deaths from...
The Radiological Society of North America (RSNA) presented its eighth Alexander R. Margulis Award for Scientific Excellence to Jae Ho Sohn, M.D., from the Radiology & Biomedical Imaging Department at the University of California in San Francisco (UCSF)

Jae Ho Sohn, M.D.

News | RSNA | December 24, 2019
December 24, 2019 — The Radiological Society of North America (R
Patient inclusion flowchart shows selection of women in the training and validation samples used for deep neural network development, as well as in the test sample (current study sample). Exclusions are detailed in the footnote. PACS = picture archiving and communication system. Image courtesy of Radiological Society of North America.

Patient inclusion flowchart shows selection of women in the training and validation samples used for deep neural network development, as well as in the test sample (current study sample). Exclusions are detailed in the footnote. PACS = picture archiving and communication system. Image courtesy of Radiological Society of North America.

News | Artificial Intelligence | December 18, 2019
December 17, 2019 — A sophisticated type of artif...
A new market report focuses on breast imaging devices, paying special attention to their recent emergence

Image courtesy of Eizo

News | Breast Imaging | December 17, 2019
December 17, 2019 — The ...