Heat maps of PSMA PET prostatic fossa recurrence in patients with recurrence limited to the prostate fossa (miTr N0 M0, n=127), pelvic nodal disease (miTr N1 M0, n=30), distant organs/extra-pelvic nodal disease (miTr N0 M1, n=32) and pelvic nodal plus distant organs/extra-pelvic nodal disease (miTr N1 M1, n=37). The yellow contour represents the RTOG CTV

June 15, 2022 — Current guidelines used to plan salvage radiation treatments in patients with local recurrence of prostate cancer should be updated to take into consideration information derived from novel imaging modalities, such as PSMA PET, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2022 Annual Meeting. The study showed that PSMA PET was effective in identifying recurrences that fell partially or fully outside of the clinical target volume as determined by current guidelines. This suggests that PSMA PET can be an invaluable tool for therapy planning.

After a biochemical recurrence of prostate cancer, salvage radiation therapy can be a curative approach. This therapy conducted following contouring guidelines based on expert consensus, such as the Radiation Therapy Oncology Group (RTOG) guidelines. In today’s era of precision medicine, study authors sought to determine if PSMA PET imaging could provide more detailed data on patterns of recurrence to inform therapy planning.

Prostate cancer patients who experienced biochemical recurrence after radical prostatectomy were included in the analysis if their PSMA PET/CT imaging showed recurrence in the prostate bed. To analyze the patterns of recurrence, two nuclear medicine physicians documented the areas of recurrence on the PSMA PET/CT, and four radiation oncologists (masked to the PSMA PET/CT findings) delineated the clinical target volume using RTOG guidelines on the CT images of the PET/CT. PSMA recurrence locations were then compared to the RTOG-based clinical target volumes.

PSMA recurrences were fully covered by the clinical target volumes in 54 percent of the patients. In 34 percent of the patients, PSMA recurrence was only partly covered, and in 13 percent of patients the PSMA recurrence was located fully outside of the clinical target volume.

“This study has the potential to redefine prostate bed contouring guidelines to improve the therapeutic ratio for patients receiving postoperative radiotherapy,” said Ida Sonni, MD, project scientist in the Department of Radiology at the University of California, Los Angeles. “Nuclear medicine and molecular imaging advances, such as PSMA PET, have the ability to guide individualized, tailored treatments that will ultimately benefit all our patients.”

For more information: www.snmmi.org

Find more SNMMI22 coverage here

Related Content

News | Radiology Business

June 29, 2022 — Siemens Healthineers and The Ohio State University Wexner Medical Center announced a new alliance, aimed ...

Time June 29, 2022
arrow
News | SNMMI

June 22, 2022 — The Society of Nuclear Medicine and Molecular Imaging recognized 15 new SNMMI Fellows on Monday, June 13 ...

Time June 22, 2022
arrow
News | SNMMI

June 22, 2022 — Andrei Iagaru, MD, FACNM, professor of radiology (nuclear medicine) and chief of the Division of Nuclear ...

Time June 22, 2022
arrow
News | PET Imaging

June 21, 2022 — Markus Schwaiger, MD, a scientist known for his contributions to cardiac PET imaging, has been named as ...

Time June 21, 2022
arrow
News | SNMMI

June 16, 2022 — Cathy Sue Cutler, PhD, FSNMMI, director of the medical isotope research and production program at ...

Time June 16, 2022
arrow
News | SPECT Imaging

June 15, 2022 — A cardiac SPECT imaging system performs scans 10 to 100 times faster than current SPECT systems ...

Time June 15, 2022
arrow
News | PET Imaging

June 15, 2022 — Poor functional outcomes after a heart attack can be predicted with a new PET imaging agent, 68Ga-FAPI ...

Time June 15, 2022
arrow
News | PET Imaging

June 15, 2022 — Patients with severe obstructive sleep apnea (OSA) are less able to increase blood flow to the heart ...

Time June 15, 2022
arrow
News | SNMMI

June 15, 2022 — Helen Nadel, MD, FRCPC, director of pediatric nuclear medicine at Lucile Packard Children’s Hospital at ...

Time June 15, 2022
arrow
News | PET-CT

June 14, 2022 — A novel artificial intelligence method can be used to generate high-quality “PET/CT” images and ...

Time June 14, 2022
arrow
Subscribe Now