News | June 22, 2009

PET Core Laboratory Plays Critical Role in Insuring Reliable Research Results

June 23, 2009 - The positron emission tomography (PET) core laboratory of the American College of Radiology Clinical Research Center serves a critical role ensuring images and image data from PET scanners used in multicenter clinical trial research meet acceptable standards according to a paper published online June 12 in the Journal of Nuclear Medicine.

This finding was based on a review of the PET scanner qualification program of the American College of Radiology Imaging Network (ACRIN) and reported by the PET core laboratory team of physicists, nuclear medicine physicians and technologists supporting the program.

“Information obtained from PET imaging has increasingly demonstrated its promising role as a non-invasive biomarker for assessing disease status. The goal of the PET qualification program is to insure we are obtaining reliable quantitative and qualitative data across all of the centers participating in PET clinical research,” states lead author Joshua Scheuermann, MS, a clinical physicist at the University of Pennsylvania.

In the past three years, ACRIN has activated a number of clinical trials with PET imaging endpoints and several more are poised to activate in the near future. The PET qualification program requires sites intending to participate in these multi-center trials to demonstrate the scanner to be used in the research protocol meets acceptable calibration standards for obtaining the standardized uptake value (SUV) and production of high quality images. “In the past several years, ACRIN has significantly expanded its PET research, and we are excited about future research projects that will evaluate novel PET radiopharmaceuticals,” says Anthony Levering, RT(R)(CT)(MR),CIIP, an assistant director of the core laboratory. “The PET qualification program provides a high level of confidence regarding the consistent handling of data.”

The authors reviewed data on the qualification of 101 PET scanners for which complete qualification data were available. They reported that, in total, of the 101 scanners to apply for PET qualification from June 2005 through June 2008, 36 sites passed the qualification review with no intervention, 57 sites passed with some type of intervention and eight sites failed and opted not to continue with the qualification process.

“The PET scanner qualification process is rigorous and requires considerable site commitment. Having qualified nearly 170 PET scanners for ACRIN research participation, it was important to evaluate the program to ensure it was making a significant difference in the quality of data collected. These results highlight the importance of a central review of a site’s data and images before data accrued on a PET scanner are used in a multi-center trial,” comments PET core laboratory medical director Barry Siegel, M.D., from Mallinckrodt Institute of Radiology at Washington University School of Medicine.

The PET core laboratory is a key component of the Diagnostic Imaging and Radiation Oncology Core Laboratory of the ACR’s Clinical Research Center located in Philadelphia. The laboratory services the center’s four research entities: ACRIN, the Radiation Therapy Oncology Group, Quality Research in Radiation Oncology, and the ACR Image Metrix.

For more information: www.acrin.org, www.acr-imagemetrix.net, www.rtog.org, www.qrro.org and www.acr-imagemetrix.net

Related Content

Study Demonstrates First Human Application of Novel PET Tracer for Prostate Cancer

Transaxial 11Csarcosine hybrid PET/CT showed a (triangulated) adenocarcinoma in the transition zone of the anterior right prostate gland on PET (A), CT (B), and a separately obtained T2?weighted MR sequence (C) with resulting PET/MRI registration (D). Image courtesy of M. Piert et al., University of Michigan, Ann Arbor, Mich.

News | Radiopharmaceuticals and Tracers | August 16, 2017
In the featured translational article in the August issue of The Journal of Nuclear Medicine, researchers at the...
Novel PET Tracer Detects Small Blood Clots

PET images (MIP 0-60 min) of three Cynomolgus monkeys. Strong signals are detected at the sites where inserted catheters had roughened surfaces. Almost no other background signal is visible. Only accumulation in the gallbladder becomes visible at the bottom of the image. Credit: Piramal Imaging GmbH, Berlin Germany.

News | PET Imaging | July 07, 2017
July 7, 2017 — Blood clots in veins a

While subject No. 1 (left) was judged as positive for both the neuronal injury and the amyloid load biomarker, both Alzheimer's disease biomarkers were negative in subject No. 2 (right). Image courtesy of Henryk Barthel et al., University Hospital Leipzig, Leipzig, Germany

News | PET Imaging | June 14, 2017
More people die of Alzheimer's disease than prostate and breast cancer combined. Identifying the disease before major...
News | Clinical Study | June 09, 2017
The milestone Imaging Dementia — Evidence for Amyloid Scanning (IDEAS) Study is working with government and academic...
Lantheus and GE Healthcare Sign Agreement for Worldwide Development, Commercialization of Flurpiridaz F-18
News | Radiopharmaceuticals and Tracers | May 22, 2017
May 22, 2017 — Lantheus Holdings Inc., parent company of Lantheus Medical Imaging Inc., and GE Healthcare announced t
low-dose lung CT scan

An example of a low-dose CT scan of the lungs, showing lung cancer. Image courtesy of Toshiba.

Feature | Lung Cancer | May 05, 2017 | Alison Grimes
The term mesothelioma was coined in 1909, just a few years after the introduction of medical X-ray imaging.
Australian Team Finds New Method for Producing PET Radiotracers in Higher Radiochemical Yields
News | Radiopharmaceuticals and Tracers | April 28, 2017
April 28, 2017 — Researchers at the Australian Nuclear Science and Technology Organisation (ANSTO) have led the devel
Sponsored Content | Videos | Nuclear Imaging | April 28, 2017
David Wolinsky, M.D., director of nuclear cardiology at Cleveland Clinic Florida and past-president of the American S
News | Prostate Cancer | April 24, 2017
April 24, 2017 — Cancer Targeted Technology recently announced it is focusing on small molecules that target pivotal
PET
Feature | Imaging | April 11, 2017 | By Greg Freiherr
Positron emission tomography (PET) and other brain assessments
Overlay Init