Nikon Instruments awarded its Small World award to the image of a cell nuclei of a mouse colon as seen through the microscope, which was generated for genomics and bioinformatics research by Dr. Paul Appleton, a researcher from the Division of Cell and Developmental Biology at the University of Dundee in the UK.
Appleton’s image grabbed first place based on its originality, informational content, technical proficiency and visual impact. The image was part of Appleton’s research to understand how cellular changes are regulated and how changes in normal cellular processes contribute to the development of colon cancer.
“Digital microscopy generates tremendous amounts of quantitative information, which is used to measure changes in normal cells,” said Dr. Appleton. “This imaging capability makes an enormous difference in the amount and quality of the information we are able to collect and analyze.”

The 2006 gallery of winning images can be viewed at

1st Prize
Dr. Paul L. Appleton
Division of Cell and Developmental Biology
University of Dundee
Dundee, UK
Cell nuclei of the mouse colon (740x)
2-Photon fluorescence

2nd Prize
Raul M. Gonzalez
Raul Gonzalez Estudio
Mexico City, Mexico
Nostoc cyanobacteria and diploneis diatom (100x)

3rd Prize
Jens Rüchel
Department of Zoology
University of Osnabrück
Osnabrück, Germany
Spirorbis sp. (aquatic worm) (100x)

4th Prize
Charles J. Kazilek
The Paper Project / W.M. Keck Bioimaging Laboratory
Arizona State University
Tempe, Arizona, USA
Lomandra longifolia (Spiny-headed mat rush) (100x)
Confocal (3-laser)

5th Prize
Dr. Heiti Paves
Tallinn University of Technology
Tallinn, Estonia
Transgenic Nicotiana benthamiana plant (10x)

6th Prize
Thomas J. Deerinck
National Center for Microscopy and Imaging Research
University of California, San Diego
La Jolla, California, USA
Rat retina astrocytes and blood vessels (160x)
Fluorescence and Confocal

7th Prize
Viktor Sykora
Institute of Pathophysiology
First Faculty of Medicine
Charles University
Prague, Czech Republic
Seed of a Clematis vitalba shrub (also known as Traveller’s Joy and Old Man’s Beard) (2x)

8th Prize
Dr. Carlos A. Munoz
Department of Biology
University of Puerto Rico, Mayaguez Campus
Mayaguez, Puerto Rico
Fluorescing filamentous green alga (60x)

9th Prize
Charles B. Krebs
Charles Krebs Photography
Issaquah, Washington, USA
Wing scales of a Urania ripheus (Sunset Moth) (6.25x)
Reflected light

10th Prize
Melissa K. Santala
Department of Materials Science and Engineering
University of California
Berkeley, California, USA
Two m-plane sapphire substrates (100x)

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