News | PET-CT | February 23, 2021

Findings indicate that PPC and GG are highly predictive of overall upstaging by PSMA PET/CT for patients with high-risk prostate cancer

Findings indicate that PPC and GG are highly predictive of overall upstaging by PSMA PET/CT for patients with high-risk prostate cancer

Image courtesy of UCLA Health


February 23, 2021 — A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center helps identify which patients with prostate cancer will benefit most from the use of prostate-specific membrane antigen PET imaging, PSMA PET, a novel imaging technique that recently was approved by the U.S. Food and Drug Administration.

By studying different variables and risk factors, researchers created a model that can be used in the clinic to identify patients who may have more extensive disease than anticipated and identify patients who are at higher risk of prostate cancer spreading to lymph nodes in the pelvis and beyond. The team found the percent of positive cores -- a metric that reflects volume of disease -- is a powerful predictor of increased nodal, metastatic and any upstaging in men with newly diagnosed high-risk prostate cancer. Patients with PPC greater than 50% and had a Gleason score of 9 or 10 (Gleason grade group 5) are the most likely to benefit from getting the PSMA PET scan.

The PSMA PET scan is an emerging imaging modality with improved sensitivity and specificity over conventional imaging for prostate cancer staging. It uses positron emission tomography (PET) in conjunction with a tracer that is highly effective in detecting prostate cancer throughout the body so the precise location of the full extent of disease can be visualized. The PSMA PET scan identifies cancer that is often missed by current standard-of-care imaging techniques. However, this scan is still not widely available and resource allocation may be a problem. Therefore, it is imperative to identify patients who are most likely to benefit from this novel imaging technique.

The team looked at 213 men who were enrolled in two prospective clinical trials at UCLA that used the PSMA PET scan as a part of primary staging of the disease. They used a multivariable logistic regression model to assess for predictors of upstaging and developed a risk calculator to further quantify the risk for each individual patient.

The findings could help predict which patients may have more cancer than anticipated, spreading to pelvic lymph nodes and beyond. An easy-to-use nomogram (calculator) was also developed as part of the effort. This is crucial for designing optimal treatment plans for each individual patient.

For more information: www.uclahealth.org

Related Content

News | Radiology Education

August 11, 2022 — After a three-year break, this spring featured the return of the anticipated Canon Roadshow Events ...

Time August 11, 2022
arrow
News | Computed Tomography (CT)

August 11, 2022 — For the first time, researchers successfully captured CT images of an entire woolly mammoth tusk ...

Time August 11, 2022
arrow
News | Radiology Imaging

August 11, 2022 — Bracco Imaging S.p.A. has announced the renewal of the “Bracco Fellowships” initiative, in partnership ...

Time August 11, 2022
arrow
News | Ultrasound Imaging

August 10, 2022 — Butterfly Network, Inc., a digital health company transforming care with handheld, whole-body ...

Time August 10, 2022
arrow
News | Point-of-Care Ultrasound (POCUS)

August 10, 2022 — Mindray North America, a global leader and developer of healthcare technologies and solutions for ...

Time August 10, 2022
arrow
News | Breast Imaging

August 8, 2022 — The U.S. Food and Drug Administration approved Enhertu (fam-trastuzumab-deruxtecan-nxki), an IV ...

Time August 08, 2022
arrow
News | Lung Imaging

August 8, 2022 — Representatives from the Diagnostics Working Group of the IASLC Early Detection and Screening Committee ...

Time August 08, 2022
arrow
News | Lung Imaging

August 8, 2022 — A clinical trial is only as powerful as its participants. For years, researchers have struggled to fill ...

Time August 08, 2022
arrow
News | X-Ray

August 5, 2022 — GE Healthcare released its most advanced fixed X-ray system yet, the next-generation Definium 656 HD ...

Time August 05, 2022
arrow
News | Lung Imaging

August 3, 2022 — Structural differences in lung airways between men and women may be the cause of differences in chronic ...

Time August 03, 2022
arrow
Subscribe Now