News | August 14, 2007

MIT Creates 3D Images Of Living Cell

August 15, 2007 – MIT recently developed a new imaging technique that reportedly allows scientists to create the first 3D images of a living cell, using a method similar to the X-ray CT scans doctors use to see inside the body.

The technique, described in a paper published in the Aug. 12 online edition of Nature Methods, could be used to produce the most detailed images yet of what goes on inside a living cell without the help of fluorescent markers or other externally added contrast agents.

Using the new technique, the research team created 3D images of cervical cancer cells, showing internal cell structures. The team also imaged C. elegans, a small worm, as well as several other cell types.

The researchers based their technique on the same concept used to create 3D CT (computed tomography) images of the human body, which allow doctors to diagnose and treat medical conditions.

The researchers made their measurements using a technique known as interferometry, in which a light wave passing through a cell is compared with a reference wave that doesn't pass through it. A 2D image containing information about refractive index is thus obtained. To create a 3D image, the researchers combined 100 2D images taken from different angles. The resulting images are essentially 3D maps of the refractive index of the cell's organelles. The entire process took about 10 seconds, but the researchers recently reduced this time to 0.1 seconds.

The team's image of a cervical cancer cell reveals the cell nucleus, the nucleolus and a number of smaller organelles in the cytoplasm. The researchers are currently in the process of better characterizing these organelles by combining the technique with fluorescence microscopy and other techniques.

For more information: web.mit.edu

Related Content

Materialise and Carestream Deploying Zero-Footprint Surgical Planning Solution
News | Medical 3-D Printing | December 14, 2018
Materialise, in collaboration with Carestream Health, is developing a work-in-progress zero-footprint deployment of...
Canon Aquilion One CT Helps Gates Vascular Institute Adhere to New Stroke Guidelines
News | Computed Tomography (CT) | December 12, 2018
In stroke, time saved on imaging is time gained in the treatment window. The recently updated guidelines from the...
GE Healthcare Partners With Department of Veterans Affairs to Accelerate 3-D Printing
News | Medical 3-D Printing | December 11, 2018
GE Healthcare and VA Puget Sound Health Care System, Washington, recently announced a partnership to accelerate the use...
Coreline Soft Introduces AI Lung Segmentation Solution at RSNA 2018
News | Lung Cancer | December 10, 2018
December 10, 2018 — Korean image software company Coreline Soft Co. Ltd.
FDA Approves New Features for Planmed Verity Cone Beam CT Scanner
Technology | Computed Tomography (CT) | December 07, 2018
The U.S. Food and Drug Administration (FDA) issued an approval letter for the new features and intended uses of the...
YITU Releases AI-Based Cancer Screening Solutions at RSNA 2018
News | Artificial Intelligence | December 06, 2018
Chinese artificial intelligence (AI) healthcare company YITU healthcare released two brand-new products, Intelligent...
Guerbet Launches Multi-Use OptiVantage Contrast Media Injector in Europe
Technology | Contrast Media Injectors | December 05, 2018
Contrast agent company Guerbet recently announced that the OptiVantage multi-use contrast media injector is now CE...
GE Healthcare Unveils New Applications and Smart Devices Built on Edison Platform
Technology | Artificial Intelligence | December 05, 2018
GE Healthcare recently announced new applications and smart devices built on Edison – a platform that helps accelerate...
Fovia Launches F.A.S.T. AI Suite for PACS
Technology | Advanced Visualization | December 05, 2018
Fovia Inc. recently announced the release of a new artificial intelligence (AI) visualization platform, F.A.S.T. AI...
Infervision Introduces AI Capabilities for Chest CT Reading
Technology | Computer-Aided Detection Software | November 30, 2018
Big data and artificial intelligence (AI) company Infervision announced the launch of InferRead CT Chest, a new product...