News | Lung Imaging | August 19, 2020

Current Lung Cancer Public Health Screening Guidelines Under Count African Americans

Public health screening guidelines for lung cancer followed by the United States Preventive Services Task Force (USPSTF) and the Center for Medicare and Medicaid Services (CMS) undercount African Americans, contributing to disparities in lung cancer screening and treatment, according to a study published today in the Journal of Thoracic Oncology.

Getty Images

August 19, 2020 — Public health screening guidelines for lung cancer followed by the United States Preventive Services Task Force (USPSTF) and the Center for Medicare and Medicaid Services (CMS) undercount African Americans, contributing to disparities in lung cancer screening and treatment, according to a study published today in the Journal of Thoracic Oncology. The JTO is the official journal of the International Association for the Study of Lung Cancer.

Current USPSTF and CMS guidelines, established by results from the National Lung Cancer Screening Trial, recommend low dose computed tomography screening for individuals that meet the following criteria: age 55-80 or 55-77 years, respectively, 30 or more pack-years cigarette smoking history, and in former smokers having quit smoking within the past 15 years.

However, African American individuals are more likely to start smoking at a later age, smoke fewer cigarettes per day, have a longer duration of smoking, are less likely to quit, and tend to be diagnosed with lung cancer at an earlier age. Previous research conducted of 48,364 ever-smokers in the Southern Community Cohort Study showed that a smaller proportion of African American individuals would have met the current USPSTF criteria compared to Whites - 17 % versus 31 %, respectively. African American ever-smokers are at increased risk for lung cancer compared to their White counterparts after adjusting for age and smoking history.

Even among those African Americans or Hispanics who are appropriately screened, access to treatment and participation in leading edge clinical trials is limited.

"Black and Hisptanic patients are under represented in cancer clinical trials and COVID-19 trials, even though they are more likely to be more affected by both diseases," said Janet Freeman-Daily at the IASLC World Conference on Lung Cancer Virtual Presidential Symposium last week. Freeman-Daily is a lung cancer patient advocate and runs the weekly lung cancer Twitter discussion #LCSM.

"In a rapid moving area like cancer care, clinical trials are treatment and represent hope," she said.

To follow up on the Southern Community Cohort Study, researchers from the University of Illinois at Chicago performed a retrospective analysis of 1,050 patients with thoracic cancer from their cancer registry. The cohort was assessed for whether each case would have been eligible by USPSTF criteria for screening based on age, pack-years (average packages of 20 cigarettes smoked per day times years smoked) and quit time. After some exclusions, the cohort of 883 ever-smokers was comprised of the following racial/ethnic makeup: 258 (29.2%) White, 497 (56.3%) African American, 69 (7.8%) Hispanic, 24 (2.7%) Asian, and 35 (4.0%) other.

The researchers analyzed this cohort using the PLCOm2012 lung cancer risk prediction screening model, based on data collected from the control arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), a randomized controlled trial studying screening to reduce cancer mortality. The PLCOm2012 model incorporates 11 predictors, which include sociodemographic, medical history, and four smoking exposure variables.

Compared to the USPSTF criteria, the PLCOm2012 model increased the sensitivity for the African American cohort at lung cancer risk thresholds of 1.51%, 1.70%, and 2.00% per 6-years. The USPSTF criteria and the PLCOm2012 model with 1.70% risk threshold identified 62.4% and 66.0% of White cases, respectively, and 50.3% and 71.3% of African American cases, respectively. Thus, the PLCOm2012 model improved sensitivity in both Whites and African American ever-smokers and eliminated the eligibility disparity. Of the 64 African Americans ever smokers who were USPSTF-ineligible because their ages were less than 55 years, 23.4% would have qualified by the PLCOm2012 with risk threshold of 1.7%. Of 53 African American ever smokers who were USPSTF-ineligible because they had quit smoking more than 15 years ago, 49.1% would have qualified by the PLCOm2012. And of the 193 of African American ever smokers who were USPSTF-ineligible because they had pack-years less than 30, 40.4% would have qualified by the PLCOm2012.

"We found that the PLCOm2012 model was significantly more sensitive in selecting lung cancer patients as being eligible for screening for the entire cohort," said lead author Mary Pasquinelli, DNP, from the University of Illinois at Chicago. "Broader use of this model in racially diverse populations may help overcome disparities in lung cancer screening and outcomes."

For more information: www.iaslc.org

Related Content

The results of an online questionnaire of 609 breast cancer survivors in the U.S. suggest that nearly half of patients experienced delays in care during the early weeks of the COVID-19 pandemic.

Getty Images

News | Coronavirus (COVID-19) | August 19, 2020
August 19, 2020 — The...
Smoking is strongly linked to lower use of cancer screening services by women, and more advanced disease once cancer is diagnosed, reveals research published in the online journal BMJ Open.

Getty Images

News | Lung Imaging | August 14, 2020
August 14, 2020 — Smoking is strongly linked to lower use of...
Sheer stresses on the walls of arteries are believed to cause the formation atherosclerotic plaques. This is an area of research that is expected to see increased use in the next few years. This study was presented at SCCT 2020 as an example of how sheer stresses can help evaluate and predict the patency of coronary artery bypass grafts (CABG).

Sheer stresses on the walls of arteries are believed to cause the formation atherosclerotic plaques. This is an area of research that is expected to see increased use in the next few years. This study was presented at SCCT 2020 as an example of how sheer stresses can help evaluate and predict the patency of coronary artery bypass grafts (CABG).

Feature | Computed Tomography (CT) | August 14, 2020
The latest technical advances and trends in...
There was a higher incidence and severity of physical intimate partner violence (IPV) among patients seen at a large, academic medical center in the U.S. during the COVID-19 pandemic compared with the prior three years, according to new a study published in Radiology.

Getty Images

News | Coronavirus (COVID-19) | August 13, 2020
August 13, 2020 — There was a higher incidence and severity of physical intimate partner violence (IPV) among patient
As healthcare providers and essential personnel work on the front lines of the COVID-19 pandemic, the U.S. Food and Drug Administration (FDA) wants clinicians to know that it is here to help through this critical time. Below is a preview of the latest recorded remarks given by FDA Commissioner, Stephen Hahn, M.D.
News | Coronavirus (COVID-19) | August 12, 2020
August 12, 2020 — As healthcare providers and essential personnel work on the front lines of the COVID-19 pandemic, t
Rafael Rivero, M.D., Global Head of Medical Affairs at MSI, said: "The importance of MyoStrain cannot be understated because of the test's immense clinical value and ability to quantify intramyocardial dysfunction across 48 segments of the heart. In a six-heartbeat MRI scan, MyoStrain arms physicians with novel clinical information about a patient's heart health."
News | Cardiac Imaging | August 11, 2020
August 11, 2020 — Myocardial Solutions, Inc. and United Imaging, Inc.
A special issue of the Journal of Medical Imaging and Radiation Sciences features stories about the interpersonal skills beyond the technical aspects to care for and guide patients through medical imaging and radiation therapy procedures

Image courtesy of Canon

News | Patient Engagement | August 11, 2020
August 11, 2020 — "I went into the MRI
Results of Journal of the American College of Surgeons study should reassure breast cancer patients who experienced surgical postponements due to COVID-19 pandemic

Association between Time to Operation and Pathological Stage in DCIS & ER+ Breast Cancer. Courtesy of American College of Surgeons

News | Women's Health | August 07, 2020
August 7, 2020 — A new br...