News | Neuro Imaging | December 05, 2017

Brain's Appetite Regulator Disrupted in Obese Teens

Researchers hope results will provide new tools to combat global public health crisis

Brain's Appetite Regulator Disrupted in Obese Teens

December 5, 2017 — Advanced magnetic resonance imaging (MRI) of obese adolescents found disrupted connectivity in the complex brain regions involving regulating appetite, according to a new study presented at the annual meeting of the Radiological Society of North America (RSNA).

According to the Centers for Disease Control and Prevention (CDC), obesity has more than quadrupled in adolescents over the past 30 years. It is estimated that more than one-third of children and adolescents in the United States are overweight or obese. Obesity in adolescence is associated with a number of health risks, including cardiovascular disease and diabetes.

The study at the University of Sao Paulo in Brazil included 59 obese adolescents between the ages of 11 and 18, and 61 healthy control adolescents matched for gender, age, socio-economicl classification and education level. The adolescents were classified by the World Health Organization criterion for obesity. They had no other known chronic diseases or conditions. The study participants underwent diffusion tensor imaging (DTI) of the brain to evaluate white matter integrity.

DTI is a type of MRI exam that measures functional anisotropy (FA), the microscopic motion of water molecules within and surrounding the brain's white matter fibers. Low FA values indicate greater disruption within the white matter.

"DTI is a relatively new MRI technique not widely used in clinical diagnosis," said study author Pamela Bertolazzi, a biomedical scientist and Ph.D. student in the neuroimaging laboratory at the University of Sao Paulo.

The results showed loss of white matter integrity in several brain regions in the obese patients. Compared to the healthy controls, the brains of the obese adolescents showed a decrease in FA values in areas of the brain including the amygdala, hippocampus, thalamus, cingulate gyrus, fornix, insula, putamen, orbital gyrus and bilateral hypothalamus. Several of these regions are involved in appetite regulation, impulse control, emotions and reward and pleasure in eating.

"The data reveal a pattern of involvement among brain regions that are important in the control of appetite and emotions," Bertolazzi said. "There was no region of higher FA in obese patients compared to the control group," she added.

The researchers hope that these findings will offer new tools to combat this global public health crisis.

"Childhood obesity has increased 10 to 40 percent in the last 10 years in most countries," Bertolazzi said. "If we are able to identify the brain changes associated with obesity, this DTI technique could be used to help prevent obesity and avoid the complications associated with the condition."

Co-authors are Prof. Fabio Duran, Ph.D., Naomi Costa, Prof. Cristiane Kochi, Ph.D., Prof. Marilia Seelaender, Ph.D., Thaysa Neves, Ph.D., Elie Calfat, Ph.D., and Prof. Ricardo Riyoiti Uchida, Ph.D.

For more information: www.radiologyinfo.org

 

Read about other Key RSNA 2017 Study Presentations, Trends and Video.

Related Content

The FLASH Effect significantly improves the therapeutic ratio for curing cancer

The FLASH Effect significantly improves the therapeutic ratio for curing cancer

News | Radiation Oncology | July 28, 2021
July 28, 2021 — IntraOp Medical Corporation announced that ...
Researchers from the School of Biomedical Engineering & Imaging Sciences at King's College London have automated brain MRI image labeling, needed to teach machine learning image recognition models, by deriving important labels from radiology reports and accurately assigning them to the corresponding MRI examinations

Getty Images

News | Magnetic Resonance Imaging (MRI) | July 28, 2021
July 28, 2021 — Researchers from the School of Biomedical Engineering & Imaging Sciences at...
64-Year-Old Man With Clear Cell Likelihood Score (ccLS) 5 Renal Masses

64-Year-Old Man With Clear Cell Likelihood Score (ccLS) 5 Renal Masses. Coronal T2-weighted single shot fast spin echo and coronal T1-weighted fat-saturated spoiled gradient echo acquired during corticomedullary phase—ccLS5 lesion outlined red for clarity.

News | Magnetic Resonance Imaging (MRI) | July 22, 2021
Registration is now open for the Radiological Society of North America (RSNA) 107th Scientific Assembly and Annual Meeting, the world’s largest annual radiology forum, to be held at McCormick Place Chicago, Nov. 28 – Dec. 2, 2021

Getty Images

News | RSNA | July 21, 2021
July 21, 2021 — Registration is now open for the Radiological Society of North America (...
Artificial intelligence-powered diagnostic tool spots asymptomatic prostate cancer in seconds

(L-R) Associate Professor Peter Brotchie (St Vincent's), Dr Ruwan Tennakoon (RMIT), Professor John Thangarajah (RMIT), Dr Mark Page (St Vincent's). Image courtesy of St Vincent's Hospital Melbourne

News | Prostate Cancer | July 19, 2021
July 19, 2021 — Prostate cancer is the most diagnosed
Ramon Alfredo Siochi, Ph.D. — the director of medical physics at WVU — led a task group to help ensure the accuracy of data that dictates a cancer patient's radiation therapy.

Ramon Alfredo Siochi, director of medical physics at West Virginia University. Image courtesy of WVU Photo/Aira Burkhart

News | Radiation Oncology | July 15, 2021
July 15, 2021 — Just as helicopter traffic reporters use their "bird's eye view" to route drivers around roadblocks s
Interviews with the 1,000 at-risk patients also led to some interesting conclusions, Fine said. Even in the early days of 3D mammography, most women interviewed had at least heard about the technology.

Getty Images

News | Mammography | July 15, 2021
July 15, 2021 —  For any type of diagnostic test, technology that helps improve the reliability of test results is a