News | Neuro Imaging | December 05, 2017

Brain's Appetite Regulator Disrupted in Obese Teens

Researchers hope results will provide new tools to combat global public health crisis

Brain's Appetite Regulator Disrupted in Obese Teens

December 5, 2017 — Advanced magnetic resonance imaging (MRI) of obese adolescents found disrupted connectivity in the complex brain regions involving regulating appetite, according to a new study presented at the annual meeting of the Radiological Society of North America (RSNA).

According to the Centers for Disease Control and Prevention (CDC), obesity has more than quadrupled in adolescents over the past 30 years. It is estimated that more than one-third of children and adolescents in the United States are overweight or obese. Obesity in adolescence is associated with a number of health risks, including cardiovascular disease and diabetes.

The study at the University of Sao Paulo in Brazil included 59 obese adolescents between the ages of 11 and 18, and 61 healthy control adolescents matched for gender, age, socio-economicl classification and education level. The adolescents were classified by the World Health Organization criterion for obesity. They had no other known chronic diseases or conditions. The study participants underwent diffusion tensor imaging (DTI) of the brain to evaluate white matter integrity.

DTI is a type of MRI exam that measures functional anisotropy (FA), the microscopic motion of water molecules within and surrounding the brain's white matter fibers. Low FA values indicate greater disruption within the white matter.

"DTI is a relatively new MRI technique not widely used in clinical diagnosis," said study author Pamela Bertolazzi, a biomedical scientist and Ph.D. student in the neuroimaging laboratory at the University of Sao Paulo.

The results showed loss of white matter integrity in several brain regions in the obese patients. Compared to the healthy controls, the brains of the obese adolescents showed a decrease in FA values in areas of the brain including the amygdala, hippocampus, thalamus, cingulate gyrus, fornix, insula, putamen, orbital gyrus and bilateral hypothalamus. Several of these regions are involved in appetite regulation, impulse control, emotions and reward and pleasure in eating.

"The data reveal a pattern of involvement among brain regions that are important in the control of appetite and emotions," Bertolazzi said. "There was no region of higher FA in obese patients compared to the control group," she added.

The researchers hope that these findings will offer new tools to combat this global public health crisis.

"Childhood obesity has increased 10 to 40 percent in the last 10 years in most countries," Bertolazzi said. "If we are able to identify the brain changes associated with obesity, this DTI technique could be used to help prevent obesity and avoid the complications associated with the condition."

Co-authors are Prof. Fabio Duran, Ph.D., Naomi Costa, Prof. Cristiane Kochi, Ph.D., Prof. Marilia Seelaender, Ph.D., Thaysa Neves, Ph.D., Elie Calfat, Ph.D., and Prof. Ricardo Riyoiti Uchida, Ph.D.

For more information: www.radiologyinfo.org

 

Read about other Key RSNA 2017 Study Presentations, Trends and Video.

Related Content

Image courtesy of Philips Healthcare

News | Clinical Trials | July 19, 2018
The use of computed tomography (CT) scans has increased dramatically over the last two decades. CT scans greatly...
CT Decision Instrument Reliably Guides Pediatric Blunt Trauma imaging Decisions

This is a four-site prospective observational cohort. Image courtesy of Kirsty Challen, B.Sc., MBCHB, MRES, Ph.D., Lancashire Teaching Hospitals, United Kingdom.

News | Clinical Decision Support | July 18, 2018
A new study finds The Pediatric NEXUS Head Computed Tomography (CT) Decision Instrument (DI) reliably identifies blunt...
Study Points to Need for Performance Standards for EHR Usability and Safety
News | Electronic Medical Records (EMR) | July 18, 2018
A novel new study provides compelling evidence that the design, development and implementation of electronic health...
Artificial Intelligence Provides Faster, Clearer MRI Scans

A new artificial-intelligence-based approach to image reconstruction, called AUTOMAP, yields higher quality images from less data, reducing radiation doses for CT and PET and shortening scan times for MRI. Shown here are MR images reconstructed from the same data with conventional approaches, at left, and AUTOMAP, at right. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital

News | Artificial Intelligence | July 17, 2018
A research team with funding from the National Institute for Biomedical Imaging and Bioengineering (NIBIB) has...
Study Shows Biomarker Panel Boosts Lung Cancer Risk Assessment for Smokers
News | Lung Cancer | July 16, 2018
A four-protein biomarker blood test improves lung cancer risk assessment over existing guidelines that rely solely upon...
Siemens Healthineers Announces FDA Clearance of syngo.via VB30 Molecular Imaging Software
Technology | Nuclear Imaging | July 16, 2018
At the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), June 23-26 in Philadelphia...
Breast Cancer Follow-up Imaging Varies Widely
News | Breast Imaging | July 13, 2018
July 13, 2018 — Follow-up imaging for women...
iSchemaView Brings RAPID Imaging Platform to Australia and New Zealand
News | Stroke | July 13, 2018
iSchemaView has signed Diagnostic Imaging Australia (DIA) to be the exclusive distributor for the RAPID cerebrovascular...
Lack of Insurance Coverage Delaying Proton Therapy Clinical Trials
News | Proton Therapy | July 12, 2018
Randomized clinical trials are the gold standard of cancer research and can shed light on whether innovative, new...
Breast Cancer Studies Ignore Race, Socioeconomic Factors
News | Women's Health | July 11, 2018
A new commentary appearing in the July issue of Cancer Causes & Control points to evidence that social factors help...
Overlay Init