News | October 29, 2006

Annual CT Scan Detects Curable Lung Cancer

Annual screening for lung cancer with CT scan can identify lung cancers at an early curable stage, resulting in high 10-year survival rates, according to results of the International Early Lung Cancer Action Program (I-ELCAP).

Previous trials have demonstrated the "spiral" CT results in the early diagnosis of lung cancer among subjects at increased risk, I-ELCAP investigators report in The New England Journal of Medicine. Until now, however, no one had investigated if early intervention affects the outcome of these patients.

The I-ELCAP study included nearly 32,000 men and women with no symptoms but who were considered have a higher than normal risk of developing lung cancer because of a history of smoking, exposure to secondhand smoke, or occupational exposure to asbestos, beryllium, uranium or radon. The subjects were at least 40 years old and underwent CT screening between 1993 and 2005.

A diagnosis of lung cancer was made in 484 subjects: 405 at their first screening, 74 during an annual screening thereafter, and 5 individuals who developed symptoms within a year of the first screening.

A total of 411 subjects underwent surgical removal of their cancer, 57 were treated with radiation or chemotherapy, and 16 received no treatment. The estimated overall 10-year survival rate was 80 percent.

Of the 484 diagnosed patients, 85 percent had clinical stage I lung cancer, the earliest type. For these patients, the estimated 10-year survival rate was 88 percent.

Lead author Dr. Claudia I. Henschke, from the Weill Medical College of Cornell University in New York, and her colleagues note that currently in the US, 95 percent of individuals diagnosed with lung cancer die within 5 years. They suggest that 80 percent of these deaths could be prevented by annual screening CT.

They also maintain that CT screening would be highly cost-effective, similar to the cost-effectiveness for mammography screening.

In an accompanying editorial, Dr. Michael Unger, from Fox Chase Cancer Center in Philadelphia, points out that the US Preventive Services Task Force concluded in 2004 that the evidence was insufficient to make a recommendation either for or against CT screening to detect lung cancer.

Unger explores the lack of progress in evaluating methods to enable early detection of lung cancer. "Unfortunately, he writes, "we have not left behind the idea that lung cancer is a punishment, not a disease" and that the associated stigma has slowed research on early detection.

He adds that the current study "is a provocative, welcome salvo in the long struggle to reduce the tremendous burden of lung cancer on society."

Related Content

Clarius Releases Clarius Live Ultrasound Telemedicine Solution
Technology | Ultrasound Imaging | May 15, 2019
Clarius Mobile Health released a telemedicine solution called Clarius Live. The simple-to-use feature allows any...
Ultrasonic Device Safe and Effective for Lung Vessel Sealing in Minimally Invasive Lobectomy
News | Interventional Radiology | May 06, 2019
According to a new study, an ultrasonic vessel-sealing device can improve patient outcomes by reducing the incidence of...
Hong Kong Polytechnic University Develops Palm-sized 3-D Scoliosis Ultrasound Imaging System
News | Ultrasound Imaging | May 03, 2019
The Hong Kong Polytechnic University (PolyU) announced the development of a palm-sized 3-D ultrasound imaging system...
Six Predictions on How the Ultrasound Systems Market Will Expand Through 2022
News | Ultrasound Imaging | April 26, 2019
With healthcare costs continuing to rise, affordable and accurate imaging and diagnosis achieved through ultrasound...
Ebit and DiA Imaging Analysis Partner on AI-based Cardiac Ultrasound Analysis
News | Cardiovascular Ultrasound | April 16, 2019
DiA Imaging Analysis has partnered with the Italian healthcare IT company Ebit (Esaote Group), to offer DiA’s LVivo...
360 Photos | 360 View Photos | April 12, 2019
This 360 degree view shows staff at the ...
DiA Imaging Analysis Introduces LVivo SAX Ultrasound Analysis Tool
Technology | Cardiovascular Ultrasound | April 09, 2019
DiA Imaging Analysis announced the launch of LVivo SAX, a cardiac analysis tool that helps clinicians quickly and...
SuperSonic Imagine Highlights Aixplorer Mach 30 Breast Ultrasound at SBI/ACR Breast Imaging Symposium
News | Ultrasound Women's Health | April 03, 2019
SuperSonic Imagine will introduce the new generation of its Aixplorer Mach 30 breast ultrasound solution at the 2019...
Videos | RSNA | April 03, 2019
ITN Editor Dave Fornell takes a tour of some of the most interesting new medical imaging technologies displa