March 9, 2023 — Contrast agents used in MRI scans to improve the clarity of imaging for diagnostic accuracy, accumulate in the brain and body of every patient, and carry an FDA “black box” warning about gadolinium, a heavy metal they use to generate contrast. Now, a revolutionary gadolinium-free contrast agent, RVP‑001, designed to provide safer contrast-enhanced MRIs for patients and to directly replace current MRI contrast agents, is being tested for the first time in a clinical trial. Reveal Pharmaceuticals has dosed the first subjects in the Phase 1 clinical trial of RVP‑001.
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