News | Orthopedic Imaging | January 11, 2018

Weight Loss Through Exercise Alone Does Not Protect Knees

A new MRI study found that cartilage degeneration in the knee joint of overweight or obese patients was no different in those who lost weight through exercise alone than from those who lost no weight at all

Weight Loss Through Exercise Alone Does Not Protect Knees

January 11, 2018 – Obese people who lose a substantial amount of weight can significantly slow down the degeneration of their knee cartilage, but only if they lose weight through diet and exercise or diet alone, according to a new magnetic resonance imaging (MRI) study presented at the annual meeting of the Radiological Society of North America (RSNA), Nov. 26-Dec. 1 in Chicago.

Obesity is a major risk factor for osteoarthritis, a degenerative joint disease that affects more than a third of adults over the age of 60, according to the Centers for Disease Control and Prevention. The knee joint is a common site of osteoarthritis, and in many people the condition progresses until total knee replacement becomes necessary.

"Once cartilage is lost in osteoarthritis, the disease cannot be reversed," said the study's lead author, Alexandra Gersing, M.D., from the Department of Radiology and Biomedical Imaging at the University of California, San Francisco.

Since cartilage loss cannot be reversed, it is important for people at risk of osteoarthritis or with early signs of the disease to slow the degeneration of cartilage. Weight loss has been shown to slow down cartilage degeneration in overweight and obese individuals, but it was unclear if the method used to lose weight made a difference.

Gersing and colleagues investigated cartilage degeneration and joint abnormalities over the course of 96 months in overweight and obese individuals who maintained stable weight and who lost weight via differing regimens.

The researchers studied 760 men and women with a body mass index of greater than 25 from the Osteoarthritis Initiative, a nationwide research study focused on the prevention and treatment of knee osteoarthritis. The patients either had mild to moderate osteoarthritis or risk factors for the disease. Patients were divided into a group of 380 patients who lost weight, and a control group of 380 patients who lost no weight. The weight-loss group was further segmented by weight loss method: diet and exercise, diet alone and exercise alone. The researchers used MRI to quantify knee osteoarthritis at the beginning of the study, at 48 months and at 96 months.

Cartilage degeneration was significantly lower in the weight loss group, compared to the control group over the 96 months. However, this finding was only present among the patients who lost weight through diet and exercise or diet alone. Although patients who only exercised lost as much weight as patients who dieted alone or dieted and exercised, weight loss through exercise alone showed no significant difference in cartilage degeneration, compared to the group who lost no weight.

"These results add to the hypothesis that solely exercise as a regimen in order to lose weight in overweight and obese adults may not be as beneficial to the knee joint as weight loss regimens involving diet," Gersing said.

Co-authors on the study are Gabby B. Joseph, Ph.D., Benedikt J. Schwaiger, M.D., Charles E. McCulloch, Ph.D., Michael C. Nevitt, Ph.D., and Thomas M. Link, M.D., Ph.D.

For more information: www.rsna.org

Key RSNA 2017 Study Presentations, Trends and Video

Related Content

Turkish Hospital Begins MR-Guided Radiation Therapy With Viewray MRIdian Linac
News | Image Guided Radiation Therapy (IGRT) | September 21, 2018
ViewRay Inc. announced that Acibadem Maslak Hospital in Istanbul, Turkey has begun treating patients with ViewRay's...
Machine Learning IDs Markers to Help Predict Alzheimer's

Neurologists use structural and diffusion magnetic resonance imaging (MRI) to identify changes in brain tissue (both gray and white matter) that are characteristic of Alzheimer's disease and other forms of dementia. The MRI images are analyzed using morphometry and tractography techniques, which detect changes in the shape and dimensions of the brain and in the tissue microstructure, respectively. In this example, the images show the normal brain of an elderly patient. Image courtesy of Jiook Cha.

News | Neuro Imaging | September 20, 2018
New research has shown a combination of two different modes of magnetic resonance imaging (MRI), computer-based...
Ingenia Ambition X 1.5T MR. This innovation is the latest advance in the Ingenia MRI portfolio, which comprises fully-digital MRI systems, healthcare informatics and a range of maintenance and life cycle services for integrated solutions that empower a faster, smarter, and simpler path to enabling a confident diagnosis
News | Magnetic Resonance Imaging (MRI) | September 14, 2018
Philips, a global leader in health technology, launched the Ingenia Ambition X 1.5T MR.
Veye Chest version 2
News | Lung Cancer | September 11, 2018
Aidence, an Amsterdam-based medical AI company, announced that Veye Chest version 2, a class IIa medical device, has
Sponsored Content | Case Study | Magnetic Resonance Imaging (MRI) | September 07, 2018 | By Sabine Sartoretti, M.D.
As soon as the Compressed SENSE technology became available to the MRI team at Kantonsspital Winterthur (Switzerland),...
Mount Sinai Serves as Official Medical Services Provider for 2018 U.S. Open
News | Orthopedic Imaging | September 06, 2018
For the sixth consecutive year, Mount Sinai will serve as the official medical services provider for the 2018 U.S. Open...
Carestream Releases Second-Generation Metal Artifact Reduction Software for OnSight 3D Extremity System
Technology | Computed Tomography (CT) | September 06, 2018
Carestream Health has started shipping a new software version for its Carestream OnSight 3D Extremity System that...

Image courtesy of Philips Healthcare

Feature | Magnetic Resonance Imaging (MRI) | September 06, 2018 | By Melinda Taschetta-Millane
According to the Prescient & Strategic Intelligence report, “Global Magnetic Resonance Imaging (MRI) Market Size,...
Konica Minolta Provides Sonimage HS1 Ultrasound for AAPM&R Hands-on Learning Course
News | Ultrasound Imaging | September 05, 2018
Konica Minolta Healthcare Americas recently provided ultrasound systems for The American Academy for Physical Medicine...
PET Imaging Agent Predicts Brain Tau Pathology, Alzheimer's Diagnosis
News | PET Imaging | September 05, 2018
Eli Lilly and Co. and Avid Radiopharmaceuticals Inc. announced a Phase 3 study of positron emission tomography (PET)...