News | April 30, 2015

Study Proves Efficacy of Second-Generation Prostate Imaging Biomarker

PET agent provides higher-quality images from first generation at half the dose

prostate cancer, [18F]DCFPyL, PSMA, biomarker, Johns Hopkins, WMIS

April 30, 2015 — A first-in-human prostate cancer study in the Journal of Molecular Imaging and Biology showed initial safety, biodistribution and dosimetry results with [18F]DCFPyL, a second-generation fluorine-18 labeled small-molecule prostate-specific membrane antigen (PSMA) inhibitor. The imaging biomarker has been developed at Johns Hopkins University in Baltimore by study co-author Martin G. Pomper, M.D., Ph.D.

“This initial human evaluation of [18F]DCFPyL demonstrated a number of important findings. The radiotracer was safe, and parallels the expected uptake with significantly improved visual conspicuity of suspected sites of metastatic prostate cancer in comparison to our first generation radiotracer,” said Pomper, William R. Brody Professor of Radiology at Johns Hopkins.

[18F]DCFPyL is a second-generation small-molecule positron emission tomography (PET) agent that attaches to the PSMA. Signals from [18F]DCFPyL can then be measured via a PET scan. The study demonstrated that [18F]DCFPyL produced images that showed lower blood pool activity, providing clearer images than the first-generation agent, [18F]DCFBC, produced by the same group. The study also showed 50 percent lower radiation dose in the most sensitive organs.

According to the American Cancer Society, about 220,800 new cases and 27,540 deaths will occur from prostate cancer in the United States in 2015. While prostate cancer is often curable, there remain a large number of patients with residual, recurrent and metastatic disease who need imaging for lesion detection, therapeutic monitoring and restaging. Conventional imaging has not proven to be sufficiently sensitive and specific for detection of prostate cancer lesions.

“The basis of more accurate, molecularly-informed classification of disease is the premise of precision medicine and specific molecular imaging biomarkers are the keys to determine how we classify diseases, how we select therapy, how we monitor therapy, and ultimately how we make treatments more accurate for each individual for better patient outcomes,” said Jason Lewis, M.D,. Ph.D., professor and vice chair for research, Emily Tow Jackson Chair at Memorial Sloan-Kettering Cancer Center, and president of the World Molecular Imaging Society (WMIS). “We commend the team at Johns Hopkins for developing a more sensitive and accurate PSMA.”

For more information: www.wmis.org

Related Content

Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Smartphone Addiction Creates Imbalance in Brain
News | Mobile Devices | January 11, 2018
Researchers have found an imbalance in the brain chemistry of young people addicted to smartphones and the internet,...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea
Minimally Invasive Treatment Provides Relief from Back Pain

Lumbar spine MRI showing disc herniation and nerve root at baseline and one month after treatment

News | Interventional Radiology | January 11, 2018
The majority of patients were pain free after receiving a new image-guided pulsed radiofrequency treatment for low back...
Emergency Radiologists See Inner Toll of Opioid Use Disorders

Rates of Imaging Positivity for IV-SUDs Complications. Image courtesy of Efren J. Flores, M.D.

News | Clinical Study | January 11, 2018
January 11, 2018 – Emergency radiologists are seeing a high prevalence of patients with complications related to opio
CT Shows Enlarged Aortas in Former Pro Football Players

3-D rendering from a cardiac CT dataset demonstrating mild dilation of the ascending aorta.

News | Computed Tomography (CT) | January 11, 2018
Former National Football League (NFL) players are more likely to have enlarged aortas, a condition that may put them at...
Study Finds No Evidence that Gadolinium Causes Neurologic Harm

MR images through, A, C, E, basal ganglia and, B, D, F, posterior fossa at level of dentate nucleus. Images are shown for, A, B, control group patient 4, and the, C, D, first and, E, F, last examinations performed in contrast group patient 13. Regions of interest used in quantification of signal intensity are shown as dashed lines for globus pallidus (green), thalamus (blue), dentate nucleus (yellow), and pons (red).

News | Contrast Media | January 11, 2018
January 11, 2018 — There is no evidence that accumulation in the brain of the element gadolinium speeds cognitive dec

Size comparison between 3-D printed prosthesis implant and a penny.

News | 3-D Printing | January 11, 2018
January 11, 2018 — Researchers using...
RSNA 2017 technical exhibits, expo floor, showing new radiology technology advances.
Feature | RSNA 2017 | January 11, 2018
January 11, 2018 — Here is a list of some of the key clinical study presentations, articles on trends and videos from
Hip Steroid Injections Associated with Bone Changes

58-year-old woman with left hip pain. X-ray from one month prior to the steroid/anesthetic injection demonstrates moderate joint space narrowing (arrows) and bony proliferation (arrowheads).

News | Orthopedic Imaging | January 11, 2018
January 11, 2018 – Osteoarthritis patients who received a steroid injection in the hip had a significantly greater in
Overlay Init