News | December 16, 2009

PET Better Identifies Malignant Breast Tumors

FDG-PET breast cancer patient.

December 17, 2009 - Positron emission tomography (PET) scans used with an agent called 64Cu-TP3805 may significantly contribute to the management of breast cancer, reducing the number of biopsies.

Scientists from the Kimmel Cancer Center at Jefferson have discovered a possible way for malignant breast tumors to be identified, without the need for a biopsy, according to findings published online in the Journal of Nuclear Medicine.

Because current imaging modalities miss up to 30 percent of breast cancers and cannot distinguish malignant tumors from benign tumors, which leads to biopsies, approximately 5.6 million biopsies performed in the United States find only benign lesions.

To better identify malignant tumors, Mathew Thakur, Ph.D., professor of Radiology at Jefferson Medical College of Thomas Jefferson University and director of Radiopharmaceutical Research and Nuclear Medicine Research conducted a study using an imaging agent to target a specific biomarker that visualizes malignant breast lesions early and reliably.

An agent called 64Cu-TP3805, which is used to evaluate tumors via PET imaging. 64Cu-TP3805 detects breast cancer by finding a biomarker called VPAC1, which is overexpressed as the tumor develops.

The researchers compared the images using that agent with images using the "gold standard" imaging agent, 18F-FDG. They used MMTVneu mice, which are mice that develop breast tumors spontaneously, like humans. The mice first received a PET scan using the 18F-FDG. Then they received a CT scan, and then they received another PET scan using 64Cu-TP3805.

Ten tumors were detected on the mice. Four tumors were detected using both 18F-FDG and 64Cu-TP3805, and four additional tumors were found with 64Cu-TP3805 only. All eight of these tumors overexpressed the VPAC1 oncogene on tumor cells and were malignant by histology. The remaining two tumors were benign and were detected only with 18F-FDG. They did not express the VPAC1 oncogene, and thus were not detected by the 64Cu-TP3805.

According to Dr. Thakur, if 64Cu-TP3805 is equally as effective in humans, then he believes PET scans with 64Cu-TP3805 will significantly contribute to the management of breast cancer.

For more information: www.snm.org

Related Content

Philips Introduces Technology Maximizer Program for Imaging Equipment Upgrades
Technology | Imaging | January 17, 2018
January 17, 2018 — Philips recently announced the launch of Technology Maximizer, a cross-modality program designed t
RSNA 2017 Celebrates Innovation in Radiology
News | Imaging | January 15, 2018
January 15, 2018 — The Radiological Society of North America’s...
Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea

Size comparison between 3-D printed prosthesis implant and a penny.

News | 3-D Printing | January 11, 2018
January 11, 2018 — Researchers using...
RSNA 2017 technical exhibits, expo floor, showing new radiology technology advances.
Feature | RSNA 2017 | January 11, 2018
January 11, 2018 — Here is a list of some of the key clinical study presentations, articles on trends and videos from
The artificial intelligence (AI) smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices.

The AI smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices. The size of the bleed volume indicates the urgency and type of treatment required.

Feature | Artificial Intelligence | January 10, 2018 | Greg Freiherr
Exhibitors at the 2017 Radiological Society of North American (RSNA) meeting rode the...
Women Prefer Getting Mammograms Every Year
News | Mammography | January 09, 2018
Women prefer to get their mammograms every year, instead of every two years, according to a new study presented at the...
Upcoming radiology conferences, meetings and events. This photo is from the 2017 RSNA opening session.
News | January 09, 2018
ITN maintains a comprehensive listing of radiology specialty meetings on its website at ...
Planmed Clarity 2-D Digital Mammography System Receives FDA Approval
Technology | Mammography | January 08, 2018
The U.S. Food and Drug Administration (FDA) issued an approval letter for the Planmed Clarity 2-D full-field digital...
Overlay Init