News | PET-CT | July 25, 2017

Full-body scan of cardiac sarcoidosis patients could reveal other areas affected by the disease

New PET-CT Scan Improves Detection in Rare Cardiac Condition

July 25, 2017 — Using a new nuclear imaging technique that can diagnose cardiac sarcoidosis much more accurately than traditional tests, researchers from the University of Illinois at Chicago have found the disease affects other organs in 40 percent of known patients with cardiac sarcoidosis. The findings are published in the Journal of Nuclear Cardiology.

Sarcoidosis is an inflammatory disease that often attacks multiple organs, particularly the lungs, heart and lymph nodes, and disproportionately affects African-Americans. Sarcoidosis can be very difficult to diagnose using available tests and available imaging techniques.

Positron emission tomography (PET) scans and computed tomography (CT) scans, as well as scans that combine information from each, have been used in the diagnosis of cardiac sarcoidosis, but the results are often unclear and hard to interpret, and lead to many false negatives.

A new combined PET-CT scan technique developed at UIC incorporates a 72-hour high-fat, low-sugar diet before images are taken. The new scan provides much clearer images of sarcoidosis and lets physicians better detect cardiac sarcoidosis. In a previous UIC study, researchers were able to diagnose cardiac sarcoidosis much more accurately and could diagnose cases that would not have been picked up using the usual 24-hour high-fat, low-sugar protocol normally prescribed before the combined PET-CT scans.

In the current study, the researchers used the new protocol to investigate the relationship between the presence of cardiac sarcoidosis and sarcoidosis in other parts of the body.

"We wanted to know if patients being evaluated for cardiac sarcoidosis would benefit from more thorough imaging of the body beyond the usual torso scan, using this new technique," said Nadera Sweiss, M.D., professor of rheumatology in the UIC College of Medicine and an author on the paper.

The researchers performed full-body (nose to knees) PET-CT scans of 188 patients who followed the 72-hour pre-test diet between Dec. 2014 and Dec. 2015 at the University of Illinois hospital, UI Health. Of the 20 scans that were positive for cardiac sarcoidosis, eight, or 40 percent, revealed sarcoidosis in other parts of the body.

"This study indicates that more extensive, full-body scans of patients with known cardiac sarcoidosis can uncover secondary sites of the disease in a significant number of patients," said Sweiss, who is also director of UI Health's Bernie Mac Sarcoidosis Translational Advanced Research (STAR) Center. "Knowing there is disease in organs other than the heart changes the way we approach treatment — it allows us to more accurately stage the disease and treat it accordingly."

Sweiss cautioned that the technique for detecting sarcoidosis outside and within the heart needs to be further tested, and its ultimate contribution to outcomes in patients with cardiac sarcoidosis will need to be evaluated.

For more information: www.onlinejnc.com

Related Content

Feature | Nuclear Imaging

The "Nuclear Medicine Market Size, Share & Trends Analysis Report by Product (Diagnostics (SPECT, PET)), Therapeutics ...

Time May 26, 2022
arrow
News | Proton Therapy

May 25, 2022 — B dot Medical Inc. and Research Center for Nuclear Physics, Osaka University (RCNP) have conducted a ...

Time May 25, 2022
arrow
News | Contrast Media

May 19 2022 — Recent disruptions in a pharmaceutical supply chain have impacted the global availability of GE Healthcare ...

Time May 19, 2022
arrow
News | Contrast Media

May 18, 2022 —According to ARRS’ American Journal of Roentgenology (AJR), to ensure that patients with emergent or life ...

Time May 18, 2022
arrow
Feature | Coronavirus (COVID-19)

Clinical scientists used machine learning (ML) models to explore de-identified electronic health record (EHR) data in ...

Time May 18, 2022
arrow
News | Radiopharmaceuticals and Tracers

May 16, 2022 — Blue Earth Diagnostics, a Bracco company and recognized leader in the development and commercialization ...

Time May 16, 2022
arrow
News | Contrast Media

May 13, 2022 — The ACR Committee on Drugs and Contrast Media, within the ACR Commission on Quality and Safety, is aware ...

Time May 13, 2022
arrow
News | Magnetic Resonance Imaging (MRI)

May 13, 2022 — Alzheimer’s disease is the most common form of dementia, one of the major causes of dependency and ...

Time May 13, 2022
arrow
News | Radiology Business

May 12, 2022 — Abbott announced a new partnership with Women as One to launch a new program designed to train more ...

Time May 12, 2022
arrow
News | Radiology Business

May 11, 2022 — Enlitic, a leading AI healthcare company, has welcomed Dave Wilson as the vice president of marketing and ...

Time May 11, 2022
arrow
Subscribe Now