News | July 28, 2008

New Irradiation Method Might Improve Bone Marrow Transplant Preconditioning Step

July 29, 2008 - People facing bone marrow transplants have a series of challenges to surmount.

One of the first is the total destruction by radiation of their bone marrow in a process called total body irradiation. This preconditions the person’s body to accept the new marrow as treatment for cancers of the blood and immune system.

Preconditioning may one day be improved if a feasibility study by a group of Chicago-area researchers is validated in further studies. In experiments using a specialized manikin-like form that is the radiological equivalent of the human body, 98 percent of the intended structures received 99 percent of prescribed radiation dose, while normal body structures were spared from high doses.

"Compared to conventional total body irradiation, this new approach reduced radiation to critical body parts such as the heart and the lungs by as much as 64 percent and 30 percent respectively which is a distinct improvement," says lead researcher Bulent Aydogan, Ph.D. of the University of Chicago.

Collaborators include researchers from the University of Illinois/Chicago and Loyola University Medical Center.

The new technique is called linac-based Intensity Modulated Total Marrow Irradiation. “Linac” refers to the linear particle accelerator used to deliver precisely planned doses of radiation to the body. Rather than dosing the entire body equally, it selectively targets bone marrow locations and administers lower radiation doses to the rest of the body.

Such accuracy is made possible by first mapping the patient’s body in 3D using a sophisticated computer scan. Next, computer programs optimize each beam of radiation into smaller “beamlets” so that each beam is individually suited to meet planned dosing goals for a given site.

Finally, a linear particle accelerator (linac) delivers these planned doses to the patient. Radiation is therefore limited to bone marrow and cancerous structures, thus sparing critical organs in the body. If further evidence supports these early findings, the team hopes to move this new treatment to clinical trials involving humans.

For more information: www.aapm.org

Source: American Association of Physicists in Medicine

Related Content

Canon Medical Receives FDA Clearance for Vantage Orian 1.5T MRI
Technology | Magnetic Resonance Imaging (MRI) | November 15, 2018
Canon Medical Systems USA Inc. received 510(k) clearance from the U.S. Food and Drug Administration (FDA) on its new...
Researchers Awarded 2018 Canon Medical Systems USA/RSNA Research Grants
News | Radiology Imaging | November 13, 2018
The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation recently announced the...
Subtle Medical Showcases Artificial Intelligence for PET, MRI Scans at RSNA 2018
News | Artificial Intelligence | November 13, 2018
At the 2018 Radiological Society of North America annual meeting (RSNA 2018), Nov. 25-30 in Chicago, Subtle Medical...
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for radiation therapy displayed for the first time since gaining FDA clearance in 2018. It was displayed at the American Society for Radiotherapy and Oncology (ASTRO) 2018 annual meeting. Read more about this system at ASTRO 2018. #ASTRO18 #ASTRO2018
360 Photos | 360 View Photos | November 07, 2018
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for...
Fans of Opposing Soccer Teams Perceive Games Differently

Image courtesy of University of York

News | Neuro Imaging | October 25, 2018
Scientists have scanned the brains of die-hard soccer fans to find out why supporters of rival teams often have very...
IMRIS, Siemens Strengthen Collaboration in Hybrid OR Neurosurgical Market
News | Hybrid OR | October 24, 2018
IMRIS, Deerfield Imaging, in partnership with Siemens Healthineers, announced a strengthened collaboration to advance...
Carotid Artery MRI Improves Cardiovascular Disease Risk Assessment
News | Magnetic Resonance Imaging (MRI) | October 23, 2018
Magnetic resonance imaging (MRI) measurements of wall thickness in the carotid arteries improve cardiovascular disease...
The Elekta Unity with 1.5T MRI embedded as a targeting system appeared at the annual meeting of the American Society of Radiation Oncology (ASTRO) in San Antonio, Texas. The system is being sold in Europe and could soon enter the U.S. marketplace. (Photo courtesy of Elekta)

The Elekta Unity with 1.5T MRI embedded as a targeting system appeared at the annual meeting of the American Society of Radiation Oncology (ASTRO) in San Antonio, Texas. The system is being sold in Europe and could soon enter the U.S. marketplace. (Photo courtesy of Elekta)

Feature | ASTRO | October 20, 2018 | By Greg Freiherr
A linear accelerator combined with high-field MRI could soon be on the U.S. market. If U.S.