News | June 09, 2014

ImaginAb Presents Initial Phase I/IIa Results for Prostate Imaging Agent at SNMMI 2014

Initial clinical experience with 89Zr-labeled anti-PSMA minibody presented

June 9, 2014 — ImaginAb Inc., in collaboration with Memorial Sloan-Kettering Cancer Center, will present at the 2014 annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) initial clinical data with an anti-PSMA (prostate-specific membrane antigen) recombinant antibody fragment (a "minibody") derived from the huJ591 monoclonal antibody, in patients with metastatic prostate cancer. The presentation of this initial data coincides with the company's preparation to expand the clinical development of the imaging agent in the United States and internationally.

89Zr-Df-IAB2M is ImaginAb's lead product candidate under development as a diagnostic imaging agent for use with positron emission tomography/computed tomography (PET/CT) for detection of soft tissue and bone lesions in men with high-risk prostate cancer. IAB2M is a monoclonal antibody fragment targeting prostate-specific membrane antigen (PSMA). PSMA is a highly promising target in prostate cancer, both because of its ubiquity and its potential as a pharmacodynamic marker of androgen depletion.

"This product has the potential to impact patient care by correctly assessing the extent of disease in several high-risk patient populations so that better clinical decisions can be made," said Christian P. Behrenbruch, Ph.D., CEO of ImaginAb. "Our prostate cancer imaging agent has demonstrated excellent sensitivity and specificity for very small lesions because of ImaginAb's unique targeting and radiochemistry strategy."

"Technologies to correctly diagnose and stage men with high-risk disease is a major unmet clinical need," said Robert Reiter, M.D., Bing professor of urology research at UCLA and co-founder of ImaginAb. "The therapeutic landscape for prostate cancer is changing at a dramatic rate and targeted molecular imaging strategies have the potential to not only impact clinical care, but fundamentally change the way we clinically validate new drugs."

This immunoPET tracer has not yet been submitted for approval by the U.S. Food and Drug Administration (FDA) for clinical use.

For more information: www.imaginab.com

Related Content

Artificial Intelligence Performs As Well As Experienced Radiologists in Detecting Prostate Cancer
News | Artificial Intelligence | April 18, 2019
University of California Los Angeles (UCLA) researchers have developed a new artificial intelligence (AI) system to...
NIH Study of Brain Energy Patterns Provides New Insights into Alcohol Effects

NIH scientists present a new method for combining measures of brain activity (left) and glucose consumption (right) to study regional specialization and to better understand the effects of alcohol on the human brain. Image courtesy of Ehsan Shokri-Kojori, Ph.D., of NIAAA.

News | Neuro Imaging | March 22, 2019
March 22, 2019 — Assessing the patterns of energy use and neuronal activity simultaneously in the human brain improve
Improving Molecular Imaging Using a Deep Learning Approach
News | Nuclear Imaging | March 21, 2019
Generating comprehensive molecular images of organs and tumors in living organisms can be performed at ultra-fast speed...
Houston Methodist Hospital Acquires Focal One High-Intensity Focused Ultrasound System
News | Focused Ultrasound Therapy | March 19, 2019
EDAP TMS SA announced that Houston Methodist Hospital, one of the first hospitals in the U.S. to offer Ablatherm...
PET Scans Show Biomarkers Could Spare Some Breast Cancer Patients from Chemotherapy
News | PET Imaging | March 18, 2019
A new study positron emission tomography (PET) scans has identified a biomarker that may accurately predict which...
Researchers Create New Method for Developing Cancer Imaging Isotopes

Prototype fluidic system for zirconium-89 purification. Image taken through a hot cell window at the Department of Radiology, University of Washington. Image courtesy of Matthew O’Hara, Pacific Northwest National Laboratory

News | Radiopharmaceuticals and Tracers | March 14, 2019
A team of researchers at the University of Washington announced they developed a new automated system for producing...
Mississippi Cancer Center Combines RayStation and TomoTherapy for Prostate Cancer Case
News | Treatment Planning | March 08, 2019
Anderson Regional Cancer Center in Meridian, Miss., has treated its first patient using the combination of RaySearch's...
Siemens Healthineers Announces First U.S. Install of Biograph Vision PET/CT
News | PET-CT | March 06, 2019
Siemens Healthineers’ new Biograph Vision positron emission tomography/computed tomography (PET/CT) system has been...
Micro-Ultrasound and Artificial Intelligence Combining to Detect Prostate Cancer
News | Prostate Cancer | February 12, 2019
Cambridge Consultants has partnered with Exact Imaging, makers of the ExactVu micro-ultrasound platform, as the two...