News | February 09, 2010

Hypofractionation for Breast As Safe As Standard Approach

February 9, 2010 - The chronic side-effects of radiotherapy for early breast cancer are not any worse when treatment is given in a lower overall dose in fewer but larger treatments, reported a study published in the Lancet Oncology.

The study, partly funded by Cancer Research UK, was part of the 4,451 patient START 1 (Standardisation of Breast Radiotherapy Trials), which found that a lower total dose of radiotherapy, delivered in fewer, larger treatments is as effective at treating the disease as the international standard of a higher total dose delivered over a longer time.

The new part of the START trial published used a questionnaire approach to assess the chronic side-effects of different radiotherapy doses for early breast cancer, as reported by women themselves.

About half the women in the trial were asked to fill in questionnaires over a five year period before and after treatment to see if they had noticed changes to the breast such as hardness, swelling and sensitivity or if they had experienced any arm or shoulder problems including pain and stiffness. These 2,208 women also answered questions on perceptions of body image.

The researchers found that long term side-effects were common for all the radiotherapy schedules with about 40 per cent of women overall reporting moderate or marked changes to the breast since treatment. Over time, breast symptoms and body image concerns did decrease.

They also found that skin changes were significantly fewer in the treatments giving lower overall dose in fewer larger doses, with a similar overall pattern for the other side effects, which supports the use of delivering radiotherapy treatment in this manner for women who have had surgery for early breast cancer.

Reference: Comparison of patient-assessed breast, arm and shoulder symptoms and body images after radiotherapy for early breast cancer was a five-year follow-up in the randomized Standardisation of Breast Radiotherapy (START) Trials, led by Penelope Hopwood, Judith Bliss, John Yarnold et al. These studies were coordinated by the Clinical Trials and Statistics Unit at The Institute of Cancer Research and funded by Cancer Research UK, the Medical Research Council and the Department of Health.

For more information:

Related Content

ASTRO and ASCO Launch New Cancer Care Quality Registry
News | Radiation Therapy | January 22, 2018
January 22, 2018 — A registry that tracks the quality of medical care provided to patients receiving cancer treatment
First Hospitals Achieve Inter-System Connectivity Across Accuray Radiation Therapy Platforms
News | Radiation Therapy | January 19, 2018
Accuray Inc. announced recently that the Heidelberg University Hospital in Heidelberg, Germany, and Oscar Lambret...
RayStation Selected for New Carbon Ion Therapy Center in Japan
News | Treatment Planning | January 18, 2018
January 18, 2018 – RayStation has been chosen as the treatment planning system for a new carbon-ion therapy facility
Raysearch Receives First Order for the Raycare Oncology Information System
News | Oncology Information Management Systems (OIMS) | January 18, 2018
January 18, 2018 – Anderson Regional Cancer Center (ARCC) in Meridian, Mississippi, has placed the first order for...
Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea
Women Prefer Getting Mammograms Every Year
News | Mammography | January 09, 2018
Women prefer to get their mammograms every year, instead of every two years, according to a new study presented at the...
Planmed Clarity 2-D Digital Mammography System Receives FDA Approval
Technology | Mammography | January 08, 2018
The U.S. Food and Drug Administration (FDA) issued an approval letter for the Planmed Clarity 2-D full-field digital...
Overweight Women May Need More Frequent Mammograms
News | Mammography | January 04, 2018
Women with higher body mass index (BMI) face an increased risk of not detecting their breast tumor until it has become...
Overlay Init