News | December 22, 2008

First Time NanoKnife Treats Lung Lesion, Lymph Node Metastasis

December 23, 2008 — The Alfred in Melbourne, Australia, used AngioDynamics’s NanoKnife system, which leverages irreversible electroporation (IRE) technology, on a lymph node metastasis and the first lung lesion case.

Ken Thomson, M.D., professor and director of the Department of Radiology at The Alfred, Monash University, performed the procedures, which the institution deemed successful from a safety perspective. The hospital will conduct further patient follow-up before determining final outcomes in terms of tumor response.

NanoKnife causes cell death by impacting the cell membranes of targeted tissue with pulses of electricity, effectively sparing nearby nerves, blood vessels, lymphatic system and other delicate structures. Targeted cells are removed from the body through blood vessels and lymphatic systems. This is different from thermal ablation modalities like cryoablation, microwave and radiofrequency ablation. These other modalities destroy all cells including critical structures in targeted tissue, leaving destroyed material in place for years. The body can only remove it slowly by attacking from the outside, as all normal pathways to remove damaged tissue have been destroyed.

“For the patient, the absence of post-operative pain is unique and remarkable,” said Dr. Thomson. “We have also treated tumors in the liver and kidney with NanoKnife, with similar experiences – no postoperative pain at all – and the procedures have raised no safety concerns. This is probably due to the fact that the supporting structure of the tissue treated is not destroyed and vascular and nerve function is unaffected.”

Regarding a previously announced liver case from The Alfred, sequential triple phase liver CT scans and ultrasound at two weeks and four weeks post-procedure have shown that a 2-cm tumor has disappeared on imaging. At the site of a 3.5-cm tumor near the diaphragm in the same patient there is only a minor nonenhancing scar. Dr Thomson noted these outcomes contrast very favorably with the cavities left following thermal ablation procedures.

AngioDynamics intends to file investigational device exemptions (IDE) with the FDA to pursue additional and more specific tissue indications. The device has been cleared for a general soft tissue ablation indication by the Food and Drug Administration.

For more information:

Related Content

RaySearch Developing RayCommand Treatment Control System for U.K. Proton Therapy Facility
Technology | Radiation Therapy | December 10, 2018
RaySearch has decided to develop a treatment control system, RayCommand, to act as a link between its RayStation...
Mirada Medical Joins U.K. Consortium Exploring Healthcare AI
News | Artificial Intelligence | December 04, 2018
Mirada Medical, a leading global brand in medical imaging software, will form part of an artificial intelligence (AI)...
Sponsored Content | Videos | Radiation Oncology | November 30, 2018
Accuray's philosophy is to personalize treatments to exactly fit the patient.
Ohio State University to Open Region’s First Proton Therapy Facility

Image courtesy of The Ohio State University James Comprehensive Cancer Center

News | Proton Therapy | November 21, 2018
The Ohio State University Wexner Medical Center and the Arthur G. James Cancer Hospital and Richard J. Solove Research...
Immune Inflammatory Levels Linked to Disease-Free Survival in Prostate Cancer
News | Prostate Cancer | November 19, 2018
Data from a validation study of a high-risk prostate cancer trial suggests that higher levels of pretreatment...
Merit Medical Completes Acquisition of Cianna Medical
News | Women's Health | November 14, 2018
Disposable device manufacturer Merit Medical Systems Inc. announced the closing of a definitive merger agreement to...
Videos | ASTRO | November 08, 2018
ITN Editor Dave Fornell took a tour of some of the most innovative technologies on display on the expo floor at the 
The Fujifilm FCT Embrace CT System displayed for the first time at ASTRO 2018.
360 Photos | 360 View Photos | November 07, 2018
Fujifilm's first FDA-cleared compu...