News | December 22, 2008

First Time NanoKnife Treats Lung Lesion, Lymph Node Metastasis

December 23, 2008 — The Alfred in Melbourne, Australia, used AngioDynamics’s NanoKnife system, which leverages irreversible electroporation (IRE) technology, on a lymph node metastasis and the first lung lesion case.

Ken Thomson, M.D., professor and director of the Department of Radiology at The Alfred, Monash University, performed the procedures, which the institution deemed successful from a safety perspective. The hospital will conduct further patient follow-up before determining final outcomes in terms of tumor response.

NanoKnife causes cell death by impacting the cell membranes of targeted tissue with pulses of electricity, effectively sparing nearby nerves, blood vessels, lymphatic system and other delicate structures. Targeted cells are removed from the body through blood vessels and lymphatic systems. This is different from thermal ablation modalities like cryoablation, microwave and radiofrequency ablation. These other modalities destroy all cells including critical structures in targeted tissue, leaving destroyed material in place for years. The body can only remove it slowly by attacking from the outside, as all normal pathways to remove damaged tissue have been destroyed.

“For the patient, the absence of post-operative pain is unique and remarkable,” said Dr. Thomson. “We have also treated tumors in the liver and kidney with NanoKnife, with similar experiences – no postoperative pain at all – and the procedures have raised no safety concerns. This is probably due to the fact that the supporting structure of the tissue treated is not destroyed and vascular and nerve function is unaffected.”

Regarding a previously announced liver case from The Alfred, sequential triple phase liver CT scans and ultrasound at two weeks and four weeks post-procedure have shown that a 2-cm tumor has disappeared on imaging. At the site of a 3.5-cm tumor near the diaphragm in the same patient there is only a minor nonenhancing scar. Dr Thomson noted these outcomes contrast very favorably with the cavities left following thermal ablation procedures.

AngioDynamics intends to file investigational device exemptions (IDE) with the FDA to pursue additional and more specific tissue indications. The device has been cleared for a general soft tissue ablation indication by the Food and Drug Administration.

For more information: www.angiodynamics.com

Related Content

Insightec Announces Expanded Reach of MR-Guided Focused Ultrasound
News | Focused Ultrasound Therapy | August 22, 2017
Insightec announced recently that worldwide adoption of magnetic resonance (MR)-guided focused ultrasound continues to...
UCLA Study Offers Roadmap to Personalized Therapies for Sarcoma
News | Oncology Diagnostics | August 22, 2017
A new UCLA study is the first to identify patient and tumor characteristics that predict the successful creation of...
Sponsored Content | Videos | Information Technology | August 22, 2017
Melissa Martin, MS, president of the American Association of Physicists in Medicine (AAPM), discusses her vision of t
Sponsored Content | Videos | Proton Therapy | August 21, 2017
Mark Pankuch, Ph.D., director of medical physics at the Northwestern Medicine Chicago Proton Center, discusses the cl
Summit Cancer Center-Boise Treats First Cancer Patients With Accuray Radixact System
News | Image Guided Radiation Therapy (IGRT) | August 21, 2017
Accuray Inc. and the Summit Cancer Center-Boise announced that the center is now treating patients with the Radixact...
MedStar Georgetown Proton Center Selects RayStation for Treatment Planning
News | Treatment Planning | August 17, 2017
August 17, 2017 — The proton center at MedStar Georgetown University Hospital will utilize RayStation for planning on
DOSIsoft Releases ISOgray Proton Therapy Treatment Planning System
Technology | Treatment Planning | August 15, 2017
DOSIsoft SA announced the official release, with CE marking, of ISOgray Treatment Planning System (TPS) release 4.3 for...
First Radixact Results Presented at AAPM 2017
News | Radiation Therapy | August 10, 2017
Accuray Inc. announced that the first studies validating the benefits of the Radixact System were presented at the 59th...
Clinical Data Supports Use of Xoft System for Endometrial Cancer
News | Brachytherapy Systems | August 03, 2017
Researchers presented clinical data supporting use of the Xoft Axxent Electronic Brachytherapy (eBx) System for the...
Overlay Init