News | February 26, 2015

Cherenkov Effect Improves Radiation Therapy for Cancer Patients

Researchers say blue light can help calculate dosimetry of X-ray photons, protons and electrons

Cherenkov effect, radiation therapy, treatment planning, dosimetry

February 26, 2015 — Investigators from Dartmouth College’s Norris Cotton Cancer Center have discovered how the complex parts of the blue light known as the Cherenkov effect can be measured and used in dosimetry to make radiation therapies safer and more effective. Findings of the study, led by Brian W. Pogue, Ph.D., and Ph.D. candidates Adam K. Glaser and Rongxiao Zhang, were published in the journal Physics in Medicine and Biology.

"The beauty of using the light from the Cherenkov Effect for dosimetry is that it's the only current method that can reveal dosimetric information completely non-invasively in water or tissue," said Glaser.

Although the phenomenon has been constructively utilized for decades in high-energy particle and astrophysics, only recently has it been investigated during radiation therapy. In this study, investigators separately measured emissions of X-ray photons, protons and electrons, and they found widely varying utility.

Based on the findings of where dose correlates with Cherenkov emission, the Dartmouth team concluded that for X-ray photons, the light emission would be optimally suited for: narrow beam stereotactic radiation therapy and surgery validation studies; verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks; near mono-energetic sources (e.g., Co-60 and brachytherapy sources); and also for entrance and exit surface imaging dosimetry of both narrow and broad beams.

For electron use, Cherenkov emission was found to be suitable only for surface dosimetry applications. Finally, for proton dosimetry, there exists a fundamental lack of Cherenkov emission at the Bragg peak, making the technique of little use, although investigators say that post-irradiation detection of light emission from radioisotopes could prove to be useful.

"By detecting this light, we can pursue novel applications of Cherenkov light emission during radiation therapy to help clinicians improve the overall treatment outcome for patients," explained Pogue.

The collaborators intend to pursue further investigation at Norris Cotton Cancer Center to find other applications where this "free" light can be useful, such as continuing clinical trials in which the Cherenkov light from X-ray beams is imaged directly from a patient's tissue surface during radiation therapy.

For more information: www.cancer.dartmouth.edu

Related Content

Videos | ASTRO | November 08, 2018
ITN Editor Dave Fornell took a tour of some of the most innovative technologies on display on the expo floor at the 
The Fujifilm FCT Embrace CT System displayed for the first time at ASTRO 2018.
360 Photos | 360 View Photos | November 07, 2018
Fujifilm's first FDA-cleared compu...
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for radiation therapy displayed for the first time since gaining FDA clearance in 2018. It was displayed at the American Society for Radiotherapy and Oncology (ASTRO) 2018 annual meeting. Read more about this system at ASTRO 2018. #ASTRO18 #ASTRO2018
360 Photos | 360 View Photos | November 07, 2018
This is the Siemens Magnetom Sola RT edition 1.5T MRI system optimized for...
GE Healthcare Discovery RF Gen 2 system displayed at ASTRO 2018. It is a dedicated computed tomography (CT) scanner for radiation oncology
360 Photos | 360 View Photos | November 07, 2018
This is the GE Healthcare Discovery RF Gen 2 system displayed at the ...
Proton Therapy for Pediatric Brain Tumors Has Favorable Cognitive Outcomes
News | Proton Therapy | November 06, 2018
Proton therapy treatment for pediatric brain tumor patients is associated with better neurocognitive outcomes compared...
Videos | Radiation Oncology | November 06, 2018
Genomics can be used to assess a patient's radiosensitivity, which can be used to increase or decrease the radiation
150-Year-Old Drug Might Improve Radiation Therapy for Cancer
News | Radiation Therapy | November 02, 2018
November 2, 2018 — A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more
A model of the new, compact, single-room Varian ProBeam 360 system. The system is an example of the trend in proton therapy toward single-room, smaller systems and away from multi-room treatment centers. #ASTRO18 #ASTRO2018

A model of the new, compact, single-room Varian ProBeam 360 system. The system is an example of the trend in proton therapy toward single-room, smaller systems and away from multi-room treatment centers.

Feature | Proton Therapy | November 01, 2018 | Dave Fornell, Editor
A few of the big takeaways from the American Societ...