News | Radiopharmaceuticals and Tracers | June 05, 2019

BGN Technologies Introduces Novel Medical Imaging Radioisotope Production Method

Novel technique enables simultaneous production of molybdenum-99 and other isotopes without the need for highly enriched, weapons-grade uranium

BGN Technologies Introduces Novel Medical Imaging Radioisotope Production Method

June 5, 2019 – BGN Technologies, the technology transfer company of Ben-Gurion University (BGU), introduced a novel method for producing radioisotopes for nuclear medicine and medical imaging technologies such as computed tomography (CT) scan and positron emission tomography-computed tomography (PET-CT).

Developed by Alexander Tsechanski, Ph.D., from the BGU Department of Nuclear Engineering, the new technique obviates the need for highly enriched, weapons-grade uranium and a nuclear reactor. Nuclear medicine often necessitates the use of technetium-99m (Tc-99m) as the isotope for imaging, an unstable technetium isotope with a only a six-hour half-life that requires onsite production. In order to produce it in an economically efficient way, currently it requires weapons-grade, highly enriched uranium and a nuclear reactor to generate molybdenum-99 (Mo-99), which decays into technetium-99m (Tc-99m).

The new invention uses the naturally occurring and stable molybdenum-100 (Mo-100) isotope and a linear electron accelerator to generate Mo-99 and Tc-99m1. This process can also simultaneously generate other short-lived radioisotopes such as F-18, O-15, N-13 and C-11 as byproducts for use in PET scans.

BGN Technologies said it is currently looking for partners for further developing and commercializing the technology.

For more information: www.in.bgu.ac.il

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Shine Medical Technologies Breaks Ground on U.S. Medical Isotope Production Facility

University of Missouri Research Reactor Files to Start U.S. Production of Medical Isotopes

FDA Clears Path for First Domestic Supply of Tc-99m Isotope

Reference

1. Fedorchenkoa D.V. and Tsechanski A. Photoneutronic aspects of the molybdenum-99 production by means of electron linear accelerators. Nuclear Inst. and Methods in Physics Research B, published online Oct. 23, 2018. https://doi.org/10.1016/j.nimb.2018.10.018

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