News | Radiopharmaceuticals and Tracers | April 13, 2017

University of Missouri Research Reactor Files to Start U.S. Production of Medical Isotopes

Facility expected to begin sending molybdenum-99 to partners in mid- to late 2018

University of Missouri Research Reactor Files to Start U.S. Production of Medical Isotopes

April 13, 2017 — The University of Missouri Research Reactor (MURR) and its partners Nordion and General Atomics (GA), announced in March that MURR’s License Amendment Request (LAR) has been submitted to the U.S. Nuclear Regulatory Commission (NRC). This marks a critical step towards implementing domestic U.S. production of molybdenum-99 (Mo-99). Once operational, production from this facility will be capable of supporting nearly half of U.S. demand for Mo-99, which currently must be imported from outside North America.

A medical isotope is a safe radioactive substance used by health professionals to diagnose and treat patients who suffer from a variety of conditions, including cardiovascular disease and cancer. Almost 50 million such procedures are performed every year. The most important isotope, technetium-99m (Tc-99m), is produced from Mo-99 and is used in more than 80 percent of all nuclear medicine procedures.

“This LAR submission shows the Nuclear Regulatory Commission that we will have all of the technology, expertise and safety measures needed to begin producing Mo-99 in place and ready to go once approval has been received,” said Ralph Butler, executive director of MURR. “As a public research institution, we are proud to play a partnership role with GA and Nordion in helping America secure a new, domestic source of Mo-99.”

Once approved by the NRC, MURR will begin producing Mo-99 using selective gaseous extraction (SGE), a proprietary technology developed by General Atomics to extract the isotope from Low Enriched Uranium (LEU) targets. This patented approach will produce Mo-99 of the highest specific activity, while avoiding the production of liquid uranium waste, a significant problem with existing technologies that require Highly Enriched Uranium (HEU). Extracted Mo-99 will be transported to Nordion’s facility in Ottawa, Ontario, for final purification and distribution to radiopharmaceutical manufacturers, after which it will be distributed to hospitals and medical facilities around the world.

Nordion will start receiving Mo-99 from MURR in mid- to late 2018, according to Phil Larabie, vice president, medical isotopes for Nordion. In addition, Nordion is maintaining its conventional Mo-99 processing capacity through March 31, 2018, in the event of a significant global shortage of Mo-99.

The MURR project is being conducted with the active support of the U.S. Department of Energy’s National Nuclear Security Administration (NNSA), which was mandated to help secure a new, reliable domestic supply of Mo-99 by the American Medical Isotopes Production Act of 2012 (AMIPA). The approval of MURR’s LAR represents a major step toward achieving this goal.

For more information: www.murr.missouri.edu

Related Content

ImaginAb Enrolls First Patient in Phase II PET Agent Clinical Trial
News | Radiopharmaceuticals and Tracers | January 30, 2019
ImaginAb Inc. announced the enrollment of the first patient in the Phase II clinical trial of the company’s CD8+ T Cell...
FDA Clears United Imaging Healthcare uExplorer Total-Body Scanner
Technology | PET-CT | January 23, 2019
January 23, 2019 — United Imaging Healthcare (United Imaging) announced U.S.
MIM Software Inc. Receives FDA 510(k) Clearance for Molecular Radiotherapy Dosimetry
Technology | Nuclear Imaging | January 16, 2019
MIM Software Inc. received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for molecular radiotherapy...
Videos | SPECT-CT | December 12, 2018
This is a walk around of the new Spectrum Dynamics Veriton SPECT-CT nuclear imaging system introduced at the 2018 ...
Spectrum Dynamics Sues GE for Theft, Misappropriation of Trade Secrets and Unfair Competition
News | SPECT Imaging | December 06, 2018
Single-photon emission computed tomography (SPECT) cardiac imaging company Spectrum Dynamics filed a lawsuit Dec. 6,...
Subtle Medical Receives FDA Clearance, CE Mark for SubtlePET
Technology | PET Imaging | December 05, 2018
Subtle Medical announced 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market SubtlePET. Subtle...
Mirada Medical Joins U.K. Consortium Exploring Healthcare AI
News | Artificial Intelligence | December 04, 2018
Mirada Medical, a leading global brand in medical imaging software, will form part of an artificial intelligence (AI)...
GE Healthcare Recalls Millennium Nuclear Medicine Systems
News | Nuclear Imaging | November 15, 2018
GE Healthcare announced it is recalling its Millennium Nuclear Medicine Systems due to an incident in which the the top...
Artificial Intelligence Predicts Alzheimer's Years Before Diagnosis
News | Neuro Imaging | November 14, 2018
Artificial intelligence (AI) technology improves the ability of brain imaging to predict Alzheimer’s disease, according...
Researchers Awarded 2018 Canon Medical Systems USA/RSNA Research Grants
News | Radiology Imaging | November 13, 2018
The Radiological Society of North America (RSNA) Research & Education (R&E) Foundation recently announced the...