News | February 08, 2013

Amyloid Imaging Shows Promise for Detecting Cardiac Amyloidosis

PET CT Journal of Nuclear Medicine Nuclear Imaging Clinical Trial Study

February 8, 2013 — While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11-C PIB can positively visualize amyloid deposits in the heart. Currently there is no noninvasive test available for specific diagnosis.

Cardiac amyloidosis is a deadly disorder caused by abnormal amyloid deposits in the heart tissue. Early diagnosis before structural change to the heart tissue has occurred is important for disease prognosis and for treatment monitoring. Currently echocardiography is the mainstay of imaging in cardiac amyloidosis; a cardiac biopsy is used to confirm diagnosis.

“Imaging with 11-C PIB provides a non-invasive and specific means of showing distribution of amyloid in an organ. This gives a unique opportunity to follow and monitor therapy, as amyloid deposits in the heart should decrease with successful therapy,” said Gunnar Antoni, Ph.D., lead author of the study “In Vivo Visualization of Amyloid Deposits in the Heart with 11-C PIB and PET.”

The study included 10 patients diagnosed with cardiac amyloidosis and five healthy individuals. PET/computed tomography (CT) with 11C-PIB was used to visualize amyloid deposits in the heart and with 11C-acetate to measure myocardial blood flow.

Uptake of 11-C PIB was measured 15-25 minutes after injection. Obvious uptake of 11-C PIB was noted in the left ventricle wall of all patients with cardiac amyloidosis, while no uptake was seen in the healthy volunteers. In half of the patients, 11-C PIB was also detected in the right ventricle wall, and nine of the patients had signs of reversible uptake, with a maximum concentration at 10-15 minutes after injection. Myocardial blood flow was significantly lower in patients with cardiac amyloidosis; however, no significant correlation between myocardial blood flow and 11-C PIB uptake was found.

“This study emphasizes the strength of molecular imaging for detecting an underlying and significant molecular aberration in a disease that presents with unspecific symptoms and signs,” noted Antoni. “The potential for molecular imaging to provide valuable information for other diseases is of great value to the field of medicine.”

For more information: jnm.snmjournals.org

Related Content

Study Explores Magnetic Nanoparticles as Bimodal Imaging Agent for PET/MRI

Image courtesy of MR Solutions.

News | PET-MRI | May 23, 2019
Researchers from Bourgogne University in Dijon, France, showed that use of superparamagnetic iron oxide nanoparticles (...
Proton Therapy Lowers Risk of Side Effects Compared to Conventional Radiation
News | Proton Therapy | May 23, 2019
Cancer patients getting proton therapy instead of traditional photon radiation are at a significantly lower risk of...
VolparaDensity With Tyrer-Cuzick Model Improves Breast Cancer Risk Stratification
News | Breast Density | May 22, 2019
Research has demonstrated use of Volpara Solutions' VolparaDensity software in combination with the Tyrer-Cuzick Breast...
Partial Breast Irradiation Effective, Convenient Treatment Option for Low-Risk Breast Cancer
News | Radiation Therapy | May 20, 2019
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast...
AI Detects Unsuspected Lung Cancer in Radiology Reports, Augments Clinical Follow-up
News | Artificial Intelligence | May 20, 2019
Digital Reasoning announced results from its automated radiology report analytics research. In a series of experiments...
New Study Evaluates Head CT Examinations and Patient Complexity
News | Neuro Imaging | May 17, 2019
Computed tomography (CT) of the head uses special X-ray equipment to help assess head injuries, dizziness and other...
New Phase 2B Trial Exploring Target-Specific Myocardial Ischemia Imaging Agent
News | Radiopharmaceuticals and Tracers | May 17, 2019
Biopharmaceutical company CellPoint plans to begin patient recruitment for its Phase 2b cardiovascular imaging study in...
Managing Architectural Distortion on Mammography Based on MR Enhancement
News | Mammography | May 15, 2019
High negative predictive values (NPV) in mammography architectural distortion (AD) without ultrasonographic (US)...
Icon Launches New Clinical Trial Patient Engagement Platform
Technology | Patient Engagement | May 14, 2019
Icon plc announced the release of its web-based clinical trial patient engagement platform, to provide patients with...
Blue Earth Diagnostics Expands Access to Axumin in Europe
News | Radiopharmaceuticals and Tracers | May 13, 2019
Blue Earth Diagnostics announced expanded access to the Axumin (fluciclovine (18F)) imaging agent in Europe. The first...