Feature | May 03, 2011

Study Shows MBI is Effective for Surgical Treatment Planning

Study Shows MBI is Effective for Surgical Treatment Planning

May 3, 2011 — Molecular breast imaging (MBI) is effective in the preoperative evaluation of women with biopsy-proven breast cancer, according to a new study by Gamma Medica Inc. and Mayo Clinic of Rochester, Minn, published in the April issue of Journal of Nuclear Medicine.

The study goals were to determine whether MBI is more sensitive than mammography in detecting additional foci of breast cancer in the ipsilateral breast, in detecting additional foci of breast cancer in the contralateral breast and in the evaluation of disease extent of biopsy-proven disease. Patients with biopsy-proven breast cancer scheduled for surgery were offered enrollment in the study. All patients had a diagnostic mammogram and an MBI study prior to surgery. Patients with MBI studies showing additional sites of disease underwent additional diagnostic studies.

At the time of operation, the pathologic findings were correlated with the MBI results. MBI studies were performed using a LumaGEM MBI system from Gamma Medica. It comprises dual-head pixilated CZT detectors mounted on a modified mammographic gantry. For MBI, patients were injected with 296 MBq Tc-99m sestamibi, and the standard CC and MLO views acquired of each breast.

Preliminary results showed that a total of 98 patients with biopsy-proven breast cancer were enrolled and underwent preoperative MBI and completed surgical resection. MBI detected additional disease greater than that identified by the combination of mammogram and ultrasound, which altered the surgical treatment in 12 patients (12/98 = 12.2 percent).

In 7 of 98 patients, MBI detected additional foci of cancer not seen on mammography (7.1 percent). This resulted in change of surgical treatment plan from breast conservation to mastectomy. Final pathology confirmed that mastectomy was warranted.

One patient (1 percent) had a contralateral breast cancer detected on MBI that was not detected with mammography. Second-look mammogram and ultrasound with biopsy demonstrated invasive breast cancer, and the patient underwent surgery on both breasts.

Two patients (2 percent) had uptake in the contralateral breast on MBI. Surgical excision demonstrated atypical ductal hyperplasia and atypical lobular hyperplasia. Another patient had an abnormality detected on MBI which, at time of planned bilateral mastectomy, was found to represent atypical ductal hyperplasia.

In 3 out of 98 patients, MBI detected a significantly greater extent of disease than mammography (3 percent) that resulted in change of surgical treatment plan from breast conservation to mastectomy.

The study's conclusion is that molecular breast imaging can detect IDC, DCIS and ILC and can play a valuable role in evaluating extent of disease and presence of multifocal disease in the breast for surgical treatment planning.

For more information: www.gammamedica.com

Related Content

Videos | Mammography | December 10, 2018
Stamatia Destounis, M.D., FACR, associate professor, University of Rochester School of Medicine, and attending radiol
FDA Clears iCAD's ProFound AI for Digital Breast Tomosynthesis
Technology | Mammography | December 07, 2018
iCAD Inc. announced clearance by the U.S. Food and Drug Administration (FDA) for their latest, deep-learning, cancer...
Spectrum Dynamics Sues GE for Theft, Misappropriation of Trade Secrets and Unfair Competition
News | SPECT Imaging | December 06, 2018
Single-photon emission computed tomography (SPECT) cardiac imaging company Spectrum Dynamics filed a lawsuit Dec. 6,...
Subtle Medical Receives FDA Clearance, CE Mark for SubtlePET
Technology | PET Imaging | December 05, 2018
Subtle Medical announced 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market SubtlePET. Subtle...
Fujifilm Collaborates With Lunit on AI Pilot Project
News | Artificial Intelligence | December 05, 2018
Fujifilm Medical Systems USA Inc. announced a joint collaboration with Korean-based medical artificial intelligence (AI...
Mirada Medical Joins U.K. Consortium Exploring Healthcare AI
News | Artificial Intelligence | December 04, 2018
Mirada Medical, a leading global brand in medical imaging software, will form part of an artificial intelligence (AI)...
ScreenPoint Medical and Volpara Partner to Bring AI to Breast Imaging Clinics
News | Computer-Aided Detection Software | December 04, 2018
ScreenPoint Medical has signed a memorandum of understanding (MOU) with Volpara Health Technologies. Volpara will...
GE Healthcare Introduces Invenia ABUS 2.0
Technology | Ultrasound Women's Health | December 03, 2018
GE Healthcare recently launched the Invenia automated breast ultrasound (ABUS) 2.0 system in the United States. This...
Snoring Poses Greater Cardiac Risk to Women
News | Women's Health | November 29, 2018
Obstructive sleep apnea (OSA) and snoring may lead to earlier impairment of cardiac function in women than in men,...
ScreenPoint Medical Receives FDA Clearance for Transpara Mammography AI Solution
Technology | Computer-Aided Detection Software | November 28, 2018
November 28, 2018 — ScreenPoint Medical announced it has received 510(k) clearance from the U.S.