News | Women's Health | July 21, 2015

University of Virginia Researchers Demonstrate High Precision of Automated Volumetric Breast Density

Scientific study confirms reduced variation between exam results with automated density measurements

July 21, 2015 - Researchers at the University of Virginia (UVA) Health System have demonstrated that automated volumetric fibroglandular breast density measurement tools are more precise than area-based methods.  Results of the study, "Reliability of Automated Breast Density Measurements," recently featured in Radiology, suggest that with lower variability, volumetric breast density is well suited for inclusion in breast cancer risk models. The announcement was made at The Association for Medical Imaging Management (AHRA)'s 43rd annual meeting and exposition, July 19-22 in Las Vegas. 

"Breast density is increasingly being considered with other known risk factors to improve risk prediction in order to give women personalized knowledge to make decisions about screening. However, variability in assigned density category may result in changes in recommendations for adjuvant screening. Thus, for consistency, objectivity, and ease of use, breast density measurement ideally should be automated and accurate," said Jennifer Harvey, M.D., professor of radiology at the UVA School of Medicine. "The purpose of this study was to estimate the reliability of area-based methods and automated volumetric breast density measurements using repeated measures."

Thirty women undergoing screening mammography consented to undergo a repeated left craniocaudal examination performed by a second technologist in this prospective study. Breast density was measured by using both area-based and volumetric methods (Volpara software). Discrepancy between the first and second breast density measurements was obtained for each algorithm by subtracting the second measurement from the first and then analyzed with a random-effects model to derive limits of measurement agreement. 

Results of the study demonstrate that variability in a repeated measurement of breast density is highest for area-based measurement tools, standard deviation 3.32 percent (2.65-4.44). In contrast, precision was highest for automated volumetric breast density tools, such as VolparaDensity, standard deviation 0.99 percent (0.79-1.33).  

"The excellent reproducibility of automated breast density measurements indicates that they would be well suited for inclusion in a breast cancer risk model.  This is consistent with results we presented at the San Antonio Breast Cancer Symposium in December that showed that the addition of volumetric breast density improved breast cancer risk discrimination," Harvey added.

For more information:

Related Content

Doctor-Patient Discussions Neglect Potential Harms of Lung Cancer Screening
News | Lung Cancer | August 15, 2018
August 15, 2018 — Although national guidelines advise doctors to discuss the benefits and harms of...
Illinois Governor Approves State Breast Density Reporting Bill Into Law
News | Breast Density | August 13, 2018
Illinois Gov. Bruce Rauner approved the Illinois Breast Density Reporting Law (Public Act 100-0749) on Aug. 10, 2018...
PET Tracer Identifies Estrogen Receptor Expression Differences in Breast Cancer Patients
News | PET Imaging | August 09, 2018
In metastatic breast cancer, prognosis and treatment is largely influenced by estrogen receptor (ER) expression of the...
iCAD Receives FDA Clearance of PowerLook Density Assessment for Digital Breast Tomosynthesis
Technology | Breast Density | August 08, 2018
iCAD announced U.S. Food and Drug Administration (FDA) clearance of its latest artificial intelligence (AI) software...
Cardiac Imaging Reveals Roots of Preeclampsia Damage in Pregnant Women
News | Women's Health | August 07, 2018
Johns Hopkins researchers say a heart imaging study of scores of pregnant women with the most severe and dangerous form...
Cardiac Monitoring a Higher Priority for High-Risk Breast Cancer Patients
News | Cardio-oncology | August 07, 2018
August 7, 2018 — While heart failure is an uncommon complication of...
Hologic Acquires Digital Specimen Radiography Company Faxitron Bioptics

VisionCT 3-D breast specimen-designated computed tomography (CT) system. Image courtesy of Faxitron Bioptics.

News | Breast Imaging | July 31, 2018
Hologic Inc. announced it has completed the acquisition of Faxitron Bioptics, a privately-held leader in digital...
Konica Minolta Hosting Lunch and Learn at 23rd Annual Mammography Meeting in Santa Fe
News | Breast Imaging | July 31, 2018
Konica Minolta Healthcare Americas Inc. will sponsor a lunch and learn featuring its Exa Mammo platform during the 23rd...
FDA Approves New Tomosynthesis Quality Control Tests for ACR Digital Mammography QC Manual
News | Mammography | July 30, 2018
The U.S. Food and Drug Administration (FDA) recently approved the American College of Radiology’s (ACR’s) amendment to...
The Magtrace and Sentimag Magnetic Localization System uses magnetic detection during sentinel lymph node biopsy procedures to identify specific lymph nodes, known as sentinel lymph nodes, for surgical removal. The FDA granted approval of the Sentimag System to Endomagnetics Inc.

The  Endomagnetics' Magtrace and Sentimag Magnetic Localization System uses magnetic detection during sentinel lymph node biopsy procedures to identify specific lymph nodes, known as sentinel lymph nodes, for surgical removal.

Technology | Women's Health | July 24, 2018
July 24, 2018 — The U.S.
Overlay Init