News | April 07, 2014

Study Indicates Breast Brachytherapy Effective for Ductal Carcinoma In Situ Breast Cancer

Strut-based breast cancer radiation treatment could expand options for DCIS patients

April 7, 2014 — Cianna Medical announced the results of a retrospective study of breast cancer patients with ductal carcinoma in situ (DCIS) treated with SAVI breast brachytherapy. Researchers reported excellent local control, with recurrence rates that appear to be equivalent to those expected for whole breast irradiation (WBI) with similar follow-up.

SAVI is a strut-based device that delivers a form of accelerated partial breast irradiation (APBI) known as breast brachytherapy, a five-day course of targeted radiation for early-stage breast cancer. With more than 10 years of clinical evidence showing excellent outcomes in efficacy and safety, breast brachytherapy is proven to be an appropriate treatment for early-stage breast cancer.

“This study adds to the growing body of research showing that brachytherapy-based APBI is a safe and effective treatment for DCIS patients,” said lead author John Einck, MD, a radiation oncologist at the University of California San Diego Moores Cancer Center. “With very low rates of recurrence that compare favorably to the data for whole breast irradiation, our data supports the use of brachytherapy in DCIS patients across a broad range of ages.”

The study reported on 248 DCIS patients treated from 2007 to 2011, making it the largest study presented to date on the use of strut-based breast brachytherapy to treat DCIS. For the entire cohort, there were five ipsilateral breast recurrences (1.75 percent recurrence rate).

Researchers stratified patients by age at the time of treatment completion (?60 yrs, ?50-<60 yrs and <50 yrs) and reported local recurrence rates for each group, which were 1.26 percent, 1.10 percent and 5.56 percent, respectively. Median follow-up was greater than two years for all three groups.

Data came from the SAVI Collaborative Research Group (SCRG), which studies the long-term outcomes of women treated with strut-based brachytherapy, and was presented at the annual meeting of the American Brachytherapy Society, April 3-5.

Similarly favorable recurrence rates with strut-based brachytherapy have been reported with even greater long-term follow-up. Data from the SCRG presented at the American Society for Radiation Oncology (ASTRO) meeting in September 2013 reported “excellent local control” with a 2 percent recurrence rate at four-and-a-half years median follow-up.

“APBI eases the burden of a breast cancer diagnosis by reducing treatment time without compromising recurrence risk,” said Catheryn Yashar, M.D., also a radiation oncologist at the UC San Diego Moores Cancer Center and co-principal investigator of the SCRG. “It’s a proven treatment for a certain group of patients, and this is yet another study that shows we can safely offer this accelerated treatment to an even larger group of women.”

Strut-based brachytherapy is used as part of breast conservation therapy (BCT), which consists of a lumpectomy followed by radiation therapy. Traditionally, the radiation portion consisted of WBI, which requires six to seven weeks of daily treatments. Breast brachytherapy delivers radiation to the area immediately surrounding the lumpectomy cavity, sparing healthy tissue from unnecessary radiation and enabling treatment to be completed in as little as five days. Patient eligibility for breast brachytherapy is based on a number of factors, including tumor size, type of cancer, age, margin status and lymph node involvement.

The strut-based, open architecture design of SAVI allows physicians to sculpt radiation based on patient-specific anatomy, which may also increase the number of women eligible for breast brachytherapy.

For more information: www.ciannamedical.com

Related Content

Clinical Data Supports Use of Xoft System for Endometrial Cancer
News | Brachytherapy Systems | August 03, 2017
Researchers presented clinical data supporting use of the Xoft Axxent Electronic Brachytherapy (eBx) System for the...
Australia's Monash Cancer Centre Treats First Early-Stage Breast Cancer Patient With Xoft System
News | Brachytherapy Systems, Women's Healthcare | May 01, 2017
iCAD Inc. announced the first early-stage breast cancer patient was treated in Australia with intraoperative radiation...
New Clinical Data on Xoft System Presented at American Brachytherapy Society Annual Meeting
News | Brachytherapy Systems, Women's Healthcare | April 20, 2017
iCAD Inc. announced that updated clinical data on the use of intraoperative radiation therapy (IORT) using the Xoft...
Concure Oncology, Breast Microseed Treatment, one day, low-dose rate brachytherapy, LDR
Technology | Brachytherapy Systems, Women's Healthcare | May 12, 2016
Concure Oncology/Breast Microseed Inc. announced the launch of its one-time, one-hour radiation treatment option for...
News | Brachytherapy Systems, Women's Healthcare | April 20, 2016
Cianna Medical Inc. announced new clinical data evaluating the Savi Scout breast localization and surgical guidance...
Gamma pro, kubtec
News | Breast Imaging | November 04, 2015
Kubtec announced the launch of the Gamma-Pro Node and Seed Location System for use in breast seed location and sentin
iCAD, Xoft Axxent, electronic brachytherapy, eBx, clinical studies, ASTRO 2015, radiation therapy

Xoft Axxent image courtesy of iCAD Inc.

News | Brachytherapy Systems | October 21, 2015
iCAD Inc. presented updated clinical data, hosted in-booth clinician presentations and showcased the latest in...
APBI, accelerated partial breast irradiation, multicatheter brachytherapy, breast conserving surgery, whole breast irradiation, WBI, ASTRO 2015
News | Brachytherapy Systems, Women's Healthcare | October 19, 2015
For some early-stage breast cancer patients, accelerated partial breast irradiation (APBI) using multicatheter...
Theragenics, Advanced Radiation Therapy LLC, AccuBoost, early stage breast cancer, brachytherapy
News | Brachytherapy Systems, Women's Healthcare | August 07, 2015
Theragenics Corp. has reached an agreement with Advanced Radiation Therapy LLC to distribute the AccuBoost technology...
Cianna Medical, SAVI Scout, breast surgical guidance system

Photo courtesy of Cianna Medical

Technology | December 16, 2014
Cianna Medical Inc. received U.S. Food and Drug Administration (FDA) clearance for the SAVI Scout surgical guidance...
Overlay Init