Technology | August 21, 2012

Siemens syngo.PET Amyloid Plaque Software Receives FDA Clearance

New software is part of comprehensive solution for the visualization and quantification of amyloid plaques in the living brain

August 21, 2012 — Siemens Healthcare announced that its syngo.PET Amyloid Plaque proprietary software has received clearance from the U.S. Food and Drug Administration (FDA) and is now available.

Joining the new Biograph mCT positron emission tomography/computed tomography (PET/CT) scanner and PETNET Solutions’ PET radiopharmaceutical production expertise, syngo.PET Amyloid Plaque software is the third element in Siemens’ comprehensive imaging solution for the visualization and quantification of amyloid plaques – one of the necessary pathological features of Alzheimer’s disease – in the living brain.

“Our new syngo.PET software, combined with Siemens’ Biograph mCT PET/CT scanner and expertise in the production of PET radiopharmaceuticals, will provide U.S. physicians with a valuable tool for the evaluation of Alzheimer’s disease and other neurologic conditions,” said Britta Fuenfstueck, CEO of molecular imaging at Siemens Healthcare.

syngo.PET Amyloid Plaque software is designed to assist physicians with assessment of beta amyloid uptake ratios in the PET scans of patients being evaluated for Alzheimer’s disease and other causes of cognitive decline. The software registers a patient’s PET amyloid images against a reference model of a PET amyloid brain to better enable the physician to target regions of interest. Siemens’ proprietary affine registration algorithm has been demonstrated in research to have a correlation coefficient of 0.98 to the Fleisher method, a reference model that identifies six optimal zones to evaluate pathological levels of amyloid plaque burden. syngo.PET Amyloid Plaque software enables physicians to quantify uptake ratios (SUVr), which can be compared to Fleisher thresholds. Quantification of amyloid-PET images with SUVr could provide information in patients with possible mild cognitive impairment that is useful in supporting visual reads of amyloid-PET images.

syngo.PET Amyloid Plaque software is cleared for use with PET and PET/CT equipment.

For more information: www.siemens.com/alzheimers

Related Content

Figure 4 for the study. Images of a 65-year-old man (patient 6). (a) Cardiac MRI perfusion shows perfusion deficit of anterior/anterolateral wall attributed to left anterior descending artery/left circumflex artery (*). (b) CT coronary angiography. (c) Coronary angiography, left anterior oblique projection with caudal angulation. (d) Three-dimensional image fusion helped refine diagnosis: perfusion deficits (*) were most likely caused by narrow first diagonal branch and its first, stented side branch.

Figure 4 for the study. Images of a 65-year-old man (patient 6). (a) Cardiac MRI perfusion shows perfusion deficit of anterior/anterolateral wall attributed to left anterior descending artery/left circumflex artery (*). (b) CT coronary angiography. (c) Coronary angiography, left anterior oblique projection with caudal angulation. (d) Three-dimensional image fusion helped refine diagnosis: perfusion deficits (*) were most likely caused by narrow first diagonal branch and its first, stented side branch (arrowhead). Retrospectively, denoted lesion could also be found at CT coronary angiography and coronary angiography (arrowheads in b and c, respectively). CT FFR = CT-derived fractional flow reserve, LGE = late gadolinium enhancement. Image courtesy of RSNA, Radiology.

News | Cardiac Imaging | May 04, 2020
May 4, 2020 – A new technique that combines computed tomography (CT) and magnetic resonance imaging MRI can bolster c
The Society of Nuclear Medicine and Molecular Imaging's 2020 annual meeting has been reimagined, and is now the SNMMI 2020 Annual Meeting — Virtual Edition
News | Coronavirus (COVID-19) | April 30, 2020
April 30, 2020 — The Society of Nuclear Medicine and Molecular Imaging's 2020 annual meeting has been reimagined, and
 Siemens Healthineers has received clearance from the Food and Drug Administration (FDA) for its AIDAN artificial intelligence technologies on the Biograph family of positron emission tomography/computed tomography (PET/CT) systems

 Siemens Healthineers received clearance from the FDA for its AIDAN artificial intelligence technologies on the Biograph family of positron emission tomography/computed tomography (PET/CT) systems.

News | Artificial Intelligence | April 22, 2020
April 22, 2020 — Siemens Healthineers has received
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 U.S. Army Spc. Jonathon Hyde and Spc. Casymn Harrison from the 1434th Engineer Company, Grayling, Mich., Michigan National Guard, prepare patient rooms at TCF Regional Care Center in Detroit in advance of receiving COVID-19 patients, April 9, 2020 #COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2

U.S. Army Spc. Jonathon Hyde and Spc. Casymn Harrison from the 1434th Engineer Company, Grayling, Mich., Michigan National Guard, prepare patient rooms at TCF Regional Care Center in Detroit in advance of receiving COVID-19 patients, April 9, 2020. The TCF Center in Detroit has been converted into a 970-bed alternative care facility for COVID-19 patients by the Federal Emergency Management Agency, in partnership with the U.S. Army Corps of Engineers and Michigan National Guard. (Photo courtesy of U.S. Air National Guard photo by Master Sgt. Scott Thompson)

Feature | Coronavirus (COVID-19) | April 15, 2020 | By Melinda Taschetta-Millane and Dave Fornell
In an effort to keep the imaging field updated on the latest information being released on coronavirus (COVID-19), th
Maximum-intensity PET projections at each time point for one rhesus monkey in the 89Zr-DFO-squaramide-anti-gD group.

Maximum-intensity PET projections at each time point for one rhesus monkey in the 89Zr-DFO-squaramide-anti-gD group. Image courtesy of Eric Berg, University of California, Davis, CA

News | PET Imaging | April 10, 2020
April 10, 2020 — Combining 89Zr-labeled antibodies with total-body...
Recommended best practices for nuclear imaging departments under the COVIF-19 pandemic have been issues by the ASNC and SNMMI. #COVID19 #ASNC #SNMMI #Coronavirus #SARScov2
News | Coronavirus (COVID-19) | April 03, 2020
April 3, 2020 — A new guidance document on best practices to maintain safety and minimize contamination in nuclear im
Novel scanners may open door for prognostic assessment in patients receiving cochlear implants

Iva Speck, MD, explains research showing that novel, fully digital, high-resolution positron emission tomography/computed tomography imaging of small brain stem nuclei can provide clinicians with valuable information concerning the auditory pathway in patients with hearing impairment. The research is featured in The Journal of Nuclear Medicine (read more at http://jnm.snmjournals.org/content/current). Video courtesy of Iva Speck, University Hospital Freiburg, Germany.

News | PET-CT | March 26, 2020
March 26, 2020 — Novel, fully digital, high-resolution...